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Calcifediol

(CAS: 19356-17-3)

Suppliers of Calcifediol

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AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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Alfa Chemistry [email protected] 1-201-478-8534 USA

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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BOC Sciences [email protected] 1-631-504-6093

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD132/5mg () USD1320/100mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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Invitrogen Corporation [email protected] (760) 603-7200 USA

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD132/5mg () USD1320/100mg ()

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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ProbeChem [email protected] 86-21-80183644

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Pure Chemistry Scientific Inc. [email protected] 857-928-2050 / 857-366-6788 USA

Fax: 617-206-9595Purity: 98% Brand:

Price and Availability: USD124/100mg (In stock)

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: Brand:

Price and Availability: USD120/5mg (In stock) USD190/10mM/1mLIn DMSO (In stock) USD470/25mg (In stock) USD1270/100mg (In stock)
Quality Control & MSDS Files: HNMR HPLC HNMR HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Price and Availability: USD132/5mg () USD1320/100mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD99/5mg () USD548/100mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

Fax: +1 (636) 207-7683Purity: Brand:

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Background Information of Calcifediol

Calcifediol(25-hydroxy Vitamin D3) is a prehormone that is produced in the liver by hydroxylation of vitamin D3 (cholecalciferol) by the enzyme cholecalciferol 25-hydroxylase IC50 value: Target: This metabolite is being measured by physicians worldwide to determine a patient's vitamin d status.Calcifediol is then converted in the kidneys (by the enzyme 25(OH)D-1α-hydroxylase) into calcitriol (1,25-(OH)2D3), a secosteroid hormone that is the active form of vitamin D.

Solubility of Calcifediol

Solubility Sources
Chloroform, Methanol MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 80 mg/mL (199.68 mM); Ethanol20 mg/mL (49.92 mM); Water<1 mg/mL (<1 mM); In vivo 2% DMSO+30% PEG 300+5% Tween+ddH2O5mg/mL Selleck Chemicals LLC

Storage Condition of Calcifediol

Storage Condition Sources

MSDS Information

MSDS Sources

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Others
Target VD/VDR
Research Area Metabolic Disease
Indications Vitamin D deficiency End stage renal disease Multiple sclerosis

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Calcifediol Montefiore Medical Center Vitamin D deficiency 2013/1/31 2014/7/31 Phase 4 Clinical
Calcifediol Seoul National University Hospital End stage renal disease 2012/7/31 2013/1/31 Phase 4 Clinical
Calcifediol Medical University of South Carolina 2013/1/31 2016/4/30 Phase 3 Clinical
Calcifediol Centre Hospitalier Universitaire de Nīmes Multiple sclerosis 2013/7/31 2017/6/30 Phase 3 Clinical
Calcifediol Indian Council For Medical Research 2010/8/31 2011/4/30 Phase 3 Clinical
Calcifediol - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
400.64 C27H44O2 19356-17-3 (S,Z)-3-((E)-2-((1R,3aS,7aR)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexanol

Structure Information of Calcifediol

Smiles C[[email protected]](CCCC(C)(O)C)[[email protected]@H]1[[email protected]](CCC/2)(C)[[email protected]](CC1)([H])C2=CC=C(C[[email protected]]3O)/C(CC3)=C
InChI InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1

Related Products

Other Form Products of Calcifediol

Name CAS Formula Suppliers
Calcifediol (monohydrate) 63283-36-3 C27H44O2 16

Recommended Products in Same Target

Name CAS Formula Suppliers
25,26-Dihydroxyvitamin D3 29261-12-9 C27H44O3 6
(24R)-MC 976 112828-09-8 C27H42O3 8
(24S)-24,25-Dihydroxyvitamin D3 55700-58-8 C27H44O3 8
Calcitriol Impurities D 103656-40-2 C28H46O3 5
Calcifediol (monohydrate) 63283-36-3 C27H44O2 16
Cholecalciferol 67-97-0 C27H44O 15
(24S)-MC 976 112849-14-6 C27H42O3 9
(1S,4R,E)-4-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-ol C39H68O3Si2 5
VD3-D6 118584-54-6 C27H38D6O 5
VD2-D3 1217448-46-8 C28H41D3O 9
25-Hydroxy VD2-D6 1262843-46-8 C28H38D6O2 9
1alpha, 25-Dihydroxy VD2-D6 216244-04-1 C28H38D6O3 9
Calcipotriol (monohydrate) 147657-22-5 C27H42O4 13
Cholecalciferol 67-97-0 C27H44O 12
Calcitriol Impurities A 73837-24-8 C27H44O3 7
(1R,3S,E)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol 910133-70-9 C27H40O3 4
Paricalcitol 131918-61-1 C27H44O3 20
MC 976 129831-99-8 C27H42O3 10
24R-Calcipotriol 112827-99-3 C27H40O3 7
MC 1046 126860-83-1 C27H38O3 8

Recommended Products in the Same Indication

Name CAS Formula Suppliers
Cetirizine 83881-51-0 C21H25ClN2O3 13
Bardoxolone 218600-44-3 C31H41NO4 17
Bardoxolone (methyl) 218600-53-4 C32H43NO4 16
Cinacalcet (hydrochloride) 364782-34-3 C22H23ClF3N 15
Aleglitazar (racemate) 475479-24-4 C24H23NO5S 6
Rolipram 61413-54-5 C16H21NO3 23
Dimethyl fumarate 624-49-7 C6H8O4 25
Cholecalciferol 67-97-0 C27H44O 15
Cinacalcet 226256-56-0 C22H22F3N 14
Calcitriol 32222-06-3 C27H44O3 28
MK-0812 624733-88-6 C24H34F3N3O3 14
Calcifediol (monohydrate) 63283-36-3 C27H44O2 16
Laquinimod 248281-84-7 C19H17ClN2O3 18
Curcumin 458-37-7 C21H20O6 26
Boceprevir 394730-60-0 C27H45N5O5 16
Firategrast 402567-16-2 C27H27F2NO6 11
Fingolimod (hydrochloride) 162359-56-0 C19H34ClNO2 20
Teriflunomide 163451-81-8 C12H9F3N2O2 20
Paricalcitol 131918-61-1 C27H44O3 20
Vitamin D2 50-14-6 C28H44O 25

Safety Data of Calcifediol

Hazard Symbols:T+,F Risk Statements:28-48/25-26-24/25-11 Safety Statements:28-36/37-45-16-7
Transport Information: HS Code: RTECS:
WGK Germany:3

Chemical and Physical Properties

Appearance: Melting point:74-76oC
Boiling point: Flash Point:14 °C
Water Solubility: Solubility:In vitro:DMSO,80 mg/mL(199.68 mM);In vitro:Ethanol,20 mg/mL(49.92 mM);In vitro:Water,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):2% DMSO+30% PEG 300+5% Tween+ddH2OFor best result
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:242-990-9
Optical Rotation: alpha:

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