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Paclitaxel

(CAS: 33069-62-4)

Suppliers of Paclitaxel

Company Name Email Tel Country
AOBIOUS INC [email protected] (508) 306-0937 USA

Fax: Purity: Brand: AOBIOUS INC

Price and Availability: USD9/1mg ()

Affix Scientific [email protected] +1-510-936-6647 USA

Fax: Purity: >99% Brand:

Price and Availability: USD1/1g (In stock) USD720/500mg (In stock)
Quality Control & MSDS Files: CoA MSDS

Alfa Chemistry [email protected] 1-201-478-8534 USA

Fax: 1-516-927-0118Purity: 0.96 Brand: Alfa Chemistry

Angelisun (Chongqing) Pharmaceutical Co., Ltd. [email protected] +86 (23) 6803-0926 ex 816 China

Fax: +86 (23) 6803-0915Purity: Brand:

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: 98% Brand: Tocris

AvaChem Scientific LLC [email protected] +1 (210) 667-3815 USA

Fax: +1 (210) 592-6206Purity: Brand:

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: Brand: BOC Sciences

Beijing Huafeng United Technology Co., Ltd. [email protected] +86 (10) 6540-5760 / 6737-4028 / +86 13366977697 China

Fax: +86 (10) 6571-2882Purity: Brand:

Beijing JingSource Pharmaceutical Technology Co., Ltd. [email protected] +86 (10) 5286-5516 China

Fax: +86 (10) 6760-2253Purity: Brand:

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 0.98 Brand: Biochempartner

Biocompounds Pharmaceutical Inc. [email protected],[email protected] +86 (21) 5768-7675 China

Fax: +86 (21) 5876-5123Purity: Brand:

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD60/50mg () USD96/100mg ()

Changsha Nutramax Inc. [email protected] +86 (731) 8293-9676 China

Fax: +86 (731) 8293-8822Purity: Brand:

Guilin Huiang Biochemistry Pharmaceutical Co., Ltd. [email protected] +86 (773) 581-1776 / 583-3018 China

Fax: +86 (773) 581-1776Purity: Brand:

Jiangsu Yew Pharmaceutical Co., Ltd. [email protected] +86 (510) 6686-5972 China

Fax: +86 (510) 6686-5972Purity: Brand:

Jinan Good Meditech Inc (GM) [email protected],[email protected] +86 (531) 5569-6087 / 5569-6089 / +86 18953105926 China

Fax: +86 (531) 5569-6088Purity: Brand:

Knowshine (Shanghai) Pharmachemicals Inc. [email protected],[email protected] +86 (21) 5132-0697 China

Fax: +86 (21) 5137-0815Purity: Brand:

LC Laboratoies [email protected] +1-781-937-0777 +1-800-937-3720 in US and Canada only USA

Fax: +1-781-938-5420Purity: 99.5% Brand:

Price and Availability: USD36/100mg (In stock) USD72/250mg (In stock) USD110/500mg (In stock) USD193/1g (In stock) USD351/2g (In stock) USD796/5g (In stock) USD1430/10g (In stock)

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD60/50mg () USD96/100mg ()
Quality Control & MSDS Files: HNMR LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: >98% Brand:

Quality Control & MSDS Files: CoA LCMS MSDS

Parling (Shanghai) PharmaTech Co., Ltd. [email protected],[email protected] +86 (21) 3616-2075 / +86 15901935043 China

Fax: +86 (21) 3616-2076Purity: Brand:

Pure Chemistry Scientific Inc. [email protected] 857-928-2050 / 857-366-6788 USA

Fax: 617-206-9595Purity: 90% Brand:

Price and Availability: USD75/1g (In stock)

Rosewa (HK) Holding Group Co., Ltd. [email protected] +86 18983840262 China

Fax: +86 (23) 6283-3877Purity: Brand:

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: >98% Brand:

Price and Availability: USD70/10mg (In stock) USD91/10mM/1mLIn DMSO (In stock) USD270/50mg (In stock)
Quality Control & MSDS Files: HNMR HPLC HNMR HPLC HNMR HPLC HNMR HPLC HPLC

Shaanxi Scidoor Hi-Tech Biology Co., Ltd. [email protected] +86 (29) 6296-0300 / 6296-0309 / 6296-0305 China

Fax: +86 (29) 6296-0320Purity: Brand:

Shanghai Bioman Pharma Limited [email protected],[email protected] +86 15000110506 China

Fax: +86 (21) 2302-5272Purity: Brand:

Shanghai Desano Co., Ltd. [email protected] +86 (21) 5132-3300 China

Fax: +86 (21) 5132-3311Purity: Brand:

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD60/50mg () USD96/100mg ()

Shanghai Jinhe Bio-Technology Co., Ltd. [email protected],[email protected] +86 (21) 5981-0660 China

Fax: +86 (21) 5981-0661Purity: Brand:

Shanghai SPE Chemicals Co., Ltd. [email protected],[email protected] +86 (21) 5138-6314 China

Fax: +86 (21) 5138-6414Purity: Brand:

Shanghai Shamrock Imp. & Exp. Trading Co., Ltd. [email protected] +86 (21) 5456-1006 China

Fax: +86 (21) 5465-6977Purity: Brand:

Shanghai Techwell Biopharmaceutical Co., Ltd. [email protected] +86 (21) 5483-1973 China

Fax: +86 (21) 2301-0563Purity: Brand:

Shenyang Tianfeng Biological Pharmaceutical Co., Ltd. [email protected] +86 (24) 2535-8166 / +86 13591688040 China

Fax: +86 (24) 8930-2166Purity: Brand:

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: 1 Brand: TargetMol

Price and Availability: USD24/2mg () USD56/10mg () USD109/25mg () USD148/50mg ()

Xi'an Sino-Herb Bio-technology Co., Ltd. [email protected] +86 (29) 8833-0278 / 8833-0490 China

Fax: +86 (29) 8833-0978Purity: Brand:

Yung Zip Chemical Co., Ltd. [email protected] +886 (4) 2681-8780 / 2681-1674 Taiwan, China

Fax: +886 (4) 2681-2911Purity: Brand:

Zhejiang Jiangbei Pharmaceutical Co., Ltd. [email protected] +86 (415) 8878-6567 China

Fax: +86 (415) 8878-6538Purity: Brand:

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Background Information of Paclitaxel

Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells. IC50 Value: 0.1 pM Target: microtubule in vitro: Paclitaxel inhibits non-endothelial type human cells at 104 - to 105 -fold higher concentrations, with IC50 of 1 nM-10 nM.

Solubility of Paclitaxel

Solubility Sources
Soluble in DMSO > 10 mM Apexbio Technology LLC
Soluble in DMSO at 200 mg/mL; soluble in ethanol at 40 mg/mL; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 μM; buffers, serum, or other additives may increase or decrease the aqueous solubility. LC Laboratoies
DMSO 100 mg/ml Ethanol 25 mg/ml MedChemexpress Co., Ltd.
Soluble in DMSO, not in water MedKoo Biosciences, Inc.
(25°C) * In vitro DMSO 171 mg/mL (200.25 mM); Ethanol18 mg/mL (21.07 mM); Water<1 mg/mL (<1 mM); In vivo 1% DMSO+30% polyethylene glycol+1% Tween 8030mg/mL Selleck Chemicals LLC

Storage Condition of Paclitaxel

Storage Condition Sources
Up to one week at 4°C or six months at -20°C. Affix Scientific
Store at -20°C Apexbio Technology LLC
Store at or below -20 oC. LC Laboratoies
Storage condition:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). Stock solution storage:0 - 4 C for short term (days to weeks), or -20 C for long term (months). Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. MedKoo Biosciences, Inc.

MSDS Information

MSDS Sources
Affix Scientific
MedChemexpress Co., Ltd.
MedKoo Biosciences, Inc.

Quality Control and Spectral Data

QC Reports Sources
[CoA] Affix Scientific
[HNMR] [LCMS] MedChemexpress Co., Ltd.
[CoA] [LCMS] MedKoo Biosciences, Inc.
[HNMR] [HPLC] Selleck Chemicals LLC

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Paclitaxel Roche Holding AG Breast tumor 2010/10/31 2012/12/31 Phase 4 Clinical
Paclitaxel Aarhus University Hospital Angina 2004/8/31 2009/1/31 Phase 4 Clinical
Paclitaxel Roche Holding AG Metastatic breast cancer 2010/3/31 2015/1/31 Phase 4 Clinical
Paclitaxel Eurocor GmbH Restenosis 2010/2/28 2011/3/01 Phase 4 Clinical
Paclitaxel Taipei-Veterans General Hospital Metastatic lung cancer 2008/4/30 2009/10/01 Phase 4 Clinical
Paclitaxel - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
853.91 C47H51NO14 33069-62-4 Taxol; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-9-(((2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl)oxy)-12-(benzoyloxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b-diyl diacetate

Structure Information of Paclitaxel

Smiles O=C(C1=CC=CC=C1)N[[email protected]@H](C2=CC=CC=C2)[[email protected]](C(O[[email protected]@H]3C(C)=C([[email protected]@H](OC(C)=O)C([[email protected]@]4(C)[[email protected]]([[email protected]@](CO5)(OC(C)=O)[[email protected]@]5([H])C[[email protected]@H]4O)([H])[[email protected]@H]6OC(C7=CC=CC=C7)=O)=O)C(C)(C)[[email protected]@]6(O)C3)=O)O
InChI InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37?,38-,40-,45+,46?,47+/m0/s1

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Safety Data of Paclitaxel

Hazard Symbols:Xn Risk Statements:37/38-41-42/43-62-68-40-48-20/21/22-68/20/21/22 Safety Statements:22-26-36/37/39-45
Transport Information: HS Code: RTECS:DA8340700
WGK Germany:3

Chemical and Physical Properties

Appearance:white-yellow solid Melting point:213 °C (dec.)(lit.)
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:6982
BRN: Refractive Index: -49 ° (C=1, MeOH)
Vapour: EINECS:205-285-7
Optical Rotation: alpha:

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