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(CAS: 451493-31-5)

Suppliers of AV-412

Company Name Email Tel Country
BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD108/5mg () USD180/10mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD108/5mg () USD180/10mg ()

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD108/5mg () USD180/10mg ()

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Background Information of AV-412

AV-412(MP-412, 2 tosylate salt) is a potent dual inhibitor of EGFR and ErbB2(IC50=19 nM) tyrosine kinases, including the mutant EGFR(L858R IC50=0.51 nM, T790M IC50=0.79 nM); inhibits autophosphorylation of EGFR and ErbB2 with IC(50) of 43 and 282 nM, respectively. IC50 value: 0.51 nM (EGFR L858R); 0.79 nM (EGFRT790M); 19 nM (ErbB2) [1] Target: EGFR; ErbB2; Mutant EGFR L858R/T790M in vitro: MP-412 (AV-412) is a potent dual inhibitor of EGFR and ErbB2 tyrosine kinases, including the mutant EGFR(L858R,T790M), which is clinically resistant to the EGFR-specific kinase inhibitors erlotinib and gefitinib.

Solubility of AV-412

Solubility Sources
DMSO MedChemexpress Co., Ltd.

Storage Condition of AV-412

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] [NP-HPLC] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways JAK/STAT Signaling Protein Tyrosine Kinase/RTK
Target EGFR
Research Area Cancer

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
AV-412 - Discontinued
AV-412 - Phase 1

Chemical Information

M.Wt Formula CAS No. Synonyms
851.41 C41H44ClFN6O7S2 451493-31-5 MP-412;AV412;AV 412;MP412;MP 412; N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-methyl-3-(4-methylpiperazin-1-yl)but-1-yn-1-yl)quinazolin-6-yl)acrylamide bis(4-methylbenzenesulfonate)

Structure Information of AV-412

Smiles O=S(C1=CC=C(C)C=C1)(O)=O.C=CC(NC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2C#CC(N5CCN(C)CC5)(C)C)=O.O=S(C6=CC=C(C)C=C6)(O)=O
InChI InChI=1S/C27H28ClFN6O.2C7H8O3S/c1-5-25(36)33-23-16-20-24(30-17-31-26(20)32-19-6-7-22(29)21(28)15-19)14-18(23)8-9-27(2,3)35-12-10-34(4)11-13-35;2*1-6-2-4-7(5-3-6)11(8,9)10/h5-7,14-17H,1,10-13H2,2-4H3,(H,33,36)(H,30,31,32);2*2-5H,1H3,(H,8,9,10)

Related Products

Other Form Products of AV-412

Name CAS Formula Suppliers
AV-412 (free base) 451492-95-8 C27H28ClFN6O 6

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Chemical and Physical Properties

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