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Dapagliflozin

(CAS: 461432-26-8)

Suppliers of Dapagliflozin

Company Name Email Tel Country
AbMole BioScience [email protected] 1-800-660-8580 USA

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AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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Affix Scientific [email protected] +1-510-936-6647 USA

Fax: Purity: >98% Brand:

Price and Availability: USD1950/500mg (In stock)
Quality Control & MSDS Files: CoA MSDS

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Apichem Chemical Technology Co., Ltd. [email protected],[email protected] +86 (21) 6199-2249 China

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Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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Arromax Pharmatech Co., Ltd. [email protected] +86 (512) 6295-4815 China

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BOC Sciences [email protected] 1-631-504-6093

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BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

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Biochem Tek(Shanghai) Co., ltd. [email protected] +86 (21) 5199-1287 China

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD84/5mg () USD144/10mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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Eastbang Pharmaceuticals Science & Technology Co., Ltd [email protected] +86-20-34703959 CHINA

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Hydragon Pharma Co., Ltd. [email protected] +86 (21) 5021-5258 / 5021-8972 China

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD84/5mg () USD144/10mg ()
Quality Control & MSDS Files: LCMS LCMS HNMR HNMR LCMS NP-HPLC MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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ProbeChem [email protected] 86-21-80183644

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Pure Chemistry Scientific Inc. [email protected] 857-928-2050 / 857-366-6788 USA

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Price and Availability: USD202/1g (In stock)

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Price and Availability: USD170/5mg (In stock) USD280/10mM/1mLIn DMSO (In stock) USD320/10mg (In stock) USD970/50mg (In stock) USD2470/200mg (In stock)
Quality Control & MSDS Files: HPLC HNMR HPLC HNMR HPLC HNMR HPLC HNMR HPLC HPLC

Shanghai Famo Bio-chemical Technology Company Ltd. [email protected],[email protected] +86 (21) 6816-0314 China

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Price and Availability: USD84/5mg () USD144/10mg ()

Shanghai Race Chemical Co., Ltd. [email protected] +86 (21) 5493-3292 China

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Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD105/10mg () USD157/50mg () USD194/100mg ()

ZHIYU Biotechnology Co., Ltd. [email protected],[email protected] +86 (512) 6279-1916 / +86 18912796596 China

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Background Information of Dapagliflozin

Dapagliflozin(BMS512148) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) is in development for the treatment of type 2 diabetes mellitus (T2DM).

Solubility of Dapagliflozin

Solubility Sources
DMSO ≥80mg/mL; Water <1mg/mL; Ethanol ≥80mg/mL MedChemexpress Co., Ltd.
Soluble in DMSO. MedKoo Biosciences, Inc.
(25°C) * In vitro DMSO 82 mg/mL (200.55 mM); Ethanol17 mg/mL (41.57 mM); Water<1 mg/mL (<1 mM); In vivo 30% PEG400+0.5% Tween80+5% Propylene glycol30 mg/mL Selleck Chemicals LLC

Storage Condition of Dapagliflozin

Storage Condition Sources
Soluble in Water <1mg/Ml, DMSO ≥82mg/mL Affix Scientific
Storage condition:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). Stock solution storage:0 - 4 C for short term (days to weeks), or -20 C for long term (months). Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. MedKoo Biosciences, Inc.

MSDS Information

MSDS Sources
Affix Scientific
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[CoA] Affix Scientific
[LCMS] [HNMR] [NP-HPLC] MedChemexpress Co., Ltd.
[HPLC] [HNMR] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Membrane Transporter/Ion Channel
Target SGLT
Research Area Metabolic Disease
Indications Cardiovascular disease Non-insulin dependent diabetes

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Dapagliflozin AstraZeneca plc Cardiovascular disease 2013/4/30 2019/4/30 Phase 3 Clinical
Dapagliflozin Bristol-Myers Squibb Co Non-insulin dependent diabetes 2012/9/30 2015/10/31 Phase 3 Clinical
Dapagliflozin Bristol-Myers Squibb Co Non-insulin dependent diabetes 2012/6/30 2014/6/30 Phase 3 Clinical
Dapagliflozin Bristol-Myers Squibb Co Non-insulin dependent diabetes 2012/7/31 2014/7/31 Phase 3 Clinical
Dapagliflozin AstraZeneca plc Non-insulin dependent diabetes 2011/10/31 2013/8/01 Phase 3 Clinical
Dapagliflozin - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
408.87 C21H25ClO6 461432-26-8 BMS-512148;BMS512148;BMS 512148; (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Structure Information of Dapagliflozin

Smiles O[[email protected]]1[[email protected]](C2=CC(CC3=CC=C(OCC)C=C3)=C(Cl)C=C2)O[[email protected]](CO)[[email protected]@H](O)[[email protected]@H]1O
InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1

Related Products

Other Form Products of Dapagliflozin

Name CAS Formula Suppliers
Dapagliflozin ((2S)-1,2-propanediol, hydrate) 960404-48-2 C24H35ClO9 10
Dapagliflozin (D5) 1204219-80-6 C21H20D5ClO6 3

Recommended Products in Same Target

Name CAS Formula Suppliers
Dapagliflozin ((2S)-1,2-propanediol, hydrate) 960404-48-2 C24H35ClO9 10
Canagliflozin (hemihydrate) 928672-86-0 C24H25FO5S 11
Phlorizin 60-81-1 C21H24O10 27
Phloretin 60-82-2 C15H14O5 31
LX-4211 1018899-04-1 C21H25ClO5S 17
Tofogliflozin (hydrate) 1201913-82-7 C22H28O7 12
PF-04971729 1210344-57-2 C22H25ClO7 6
Empagliflozin 864070-44-0 C23H27ClO7 22
Tofogliflozin 903565-83-3 C22H26O6 10
Ipragliflozin 761423-87-4 C21H21FO5S 17
Canagliflozin 842133-18-0 C24H25FO5S 24
Bexagliflozin 1118567-05-7 C24H29ClO7 12
PF-04971729 1210344-57-2 C22H25ClO7 13
TP0438836 C27H38N2O10 0

Recommended Products in the Same Indication

Name CAS Formula Suppliers
Glibenclamide 10238-21-8 C23H28ClN3O5S 30
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Teneligliptin 760937-92-6 C22H30N6OS 12
Empagliflozin 864070-44-0 C23H27ClO7 22
MK 0893 870823-12-4 C32H27Cl2N3O4 10
Canagliflozin 842133-18-0 C24H25FO5S 24
Manidipine (dihydrochloride) 89226-75-5 C35H40Cl2N4O6 17
Teneligliptin (hydrobromide) 906093-29-6 C44H65Br5N12O2S2 13
Exendin-4 (Acetate) 914454-01-6 C186H286N50O62S 8
5-R-Rivaroxaban 865479-71-6 C19H18ClN3O5S 8
Trelagliptin 865759-25-7 C18H20FN5O2 18
Linagliptin 668270-12-0 C25H28N8O2 23
Bardoxolone (methyl) 218600-53-4 C32H43NO4 16
Saxagliptin 361442-04-8 C18H25N3O2 22
Rivaroxaban 366789-02-8 C19H18ClN3O5S 26
Alogliptin 850649-61-5 C18H21N5O2 14
Alogliptin (Benzoate) 850649-62-6 C25H27N5O4 21
Aleglitazar (racemate) 475479-24-4 C24H23NO5S 6
Imeglimin (hydrochloride) 775351-61-6 C6H14ClN5 10
Imeglimin 775351-65-0 C6H13N5 10

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,82 mg/mL(200.55 mM);In vitro:Ethanol,17 mg/mL(41.57 mM);In vitro:Water,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):30% PEG400+0.5% Tween80+5% propylene glycolFor be
Density:1.349 Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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