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Letrozole

(CAS: 112809-51-5)

Suppliers of Letrozole

Company Name Email Tel Country
AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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BOC Sciences [email protected] 1-631-504-6093

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Beijing Dezhong Wanquan Medicines Technological Development Co., Ltd. [email protected] +86 (10) 8850-0088 ex 206 China

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Beijing FaMuRuiSi Pharmaceuticals Co., Ltd. [email protected] +86 (10) 6125-2196 / +86 18901358086 China

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Beijing Team Academy of Pharmaceutical Sciences Co., Ltd. [email protected],[email protected] +86 (10) 6818-0921 China

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BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

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Broad Pharmaceutical Co., Ltd. [email protected] +86 (10) 5173-3671 / 5173-3670 / 5173-3669 China

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD72/100mg () USD77/200mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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Hangzhou Hysen Pharma Co., Ltd. [email protected] +86 (571) 8829-8691 China

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Hangzhou Rongda Pharm & Chem Co., Ltd. [email protected] +86 (571) 2828-1880 / 2828-1885 China

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Heta Pharm & Chem Co., Ltd. [email protected],[email protected] +86 (571) 8829-8691 China

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Lianyungang Guike Pharmaceutical Co., ltd. [email protected] +86 (518) 8607-0808 / 8607-0855 China

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD72/100mg () USD77/200mg ()
Quality Control & MSDS Files: HNMR LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Price and Availability: USD97/25mg (In stock) USD170/50mg (In stock) USD470/200mg (In stock) USD480/10mM/1mLIn DMSO (In stock)
Quality Control & MSDS Files: HPLC HNMR HPLC HNMR HPLC HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Price and Availability: USD72/100mg () USD77/200mg ()

Suzhou Unite Pharmtech Co., Ltd. [email protected],[email protected] +86 (512) 8766-6020 / +86 13222993784 China

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Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD20/2mg () USD63/10mg () USD112/25mg () USD198/50mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

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Wonder Synthesis (Beijing) Science and Development Co., Ltd. [email protected],[email protected] +86 (10) 8482-6062 China

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Xiangfan Goto Chemical Co., Ltd [email protected] +86-710-3423122 3423123 CHINA

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Background Information of Letrozole

Letrozole(CGS-20267) is an oral non-steroidal aromatase inhibitor that has been introduced for the adjuvant. Target: Others Approved: July 25, 1997 Letrozole potently inhibits aromatase derived from a variety of different sources including human placental microsomes, particulate fractions of human breast cancer, rat ovarian microsomes, MCF-7 cells transfected with aromatase (MCF-7Ca), JEG-3 human choriocarcinoma cells , CHO cells, hamster ovarian tissue, and particulate fractions of human breast cancer with IC50 of 11, 2, 7, 0.07, 0.07, 1.4, 20 and 0.8 nM.

Solubility of Letrozole

Solubility Sources
DMSO 57 mg/mL Water <1 mg/mL Ethanol <1 mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 57 mg/mL (199.78 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM); In vivo 0.5% CMC10 mg/mL Selleck Chemicals LLC
Soluble to 100 mM in DMSO Tocris Bioscience Inc.

Storage Condition of Letrozole

Storage Condition Sources
Store at +4°C Tocris Bioscience Inc.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.
[HPLC] [HNMR] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Autophagy Others
Target Autophagy Aromatase
Research Area Cancer
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Letrozole - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
285.3 C17H11N5 112809-51-5 4,4'-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile; 4,4'-((1H-1,2,4-triazol-1-yl)methylene)dibenzonitrile

Structure Information of Letrozole

Smiles N#CC1=CC=C(C=C1)C(N2C=NC=N2)C3=CC=C(C#N)C=C3
InChI InChI=1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:181-183°C
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,57 mg/mL(199.78 mM);In vitro:Water,Insoluble;In vitro:Ethanol,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):0.5% CMC NaFor best results, use promptly after mixing.,10
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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