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Bicalutamide

(CAS: 90357-06-5)

Suppliers of Bicalutamide

Company Name Email Tel Country
Alfa Chemistry [email protected] 1-201-478-8534 USA

Fax: 1-516-927-0118Purity: 0.96 Brand: Alfa Chemistry

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 0.98 Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD60/100mg () USD74/200mg ()

Chongqing Biocare Pharmaceutical Co., Ltd [email protected] 023-61728298 CHINA

Fax: 023-61728296Purity: Brand:

Hangzhou Hysen Pharma Co., Ltd. [email protected] +86 (571) 8829-8691 China

Fax: +86 (571) 2891-8299Purity: Brand:

Heta Pharm & Chem Co., Ltd. [email protected],[email protected] +86 (571) 8829-8691 China

Fax: +86 (571) 8993-7386Purity: Brand:

Lianyungang Guike Pharmaceutical Co., ltd. [email protected] +86 (518) 8607-0808 / 8607-0855 China

Fax: +86 (518) 8607-0852Purity: Brand:

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD60/100mg () USD74/200mg ()
Quality Control & MSDS Files: LCMS HNMR MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: >98% Brand:

Qufu Hongly Chemical Industry Co., Ltd. [email protected] +86 (537) 448-1166 / 449-1986 / 449-1996 China

Fax: +86 (537) 449-6569Purity: Brand:

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: >98% Brand:

Price and Availability: USD109/10mM/1mLIn DMSO (In stock) USD120/50mg (In stock) USD210/100mg (In stock) USD370/200mg (In stock)
Quality Control & MSDS Files: HPLC HNMR HPLC HPLC HPLC HNMR HPLC HNMR HPLC

ShangHai PuYi Chemical Co., Ltd. [email protected],[email protected] +86 (21) 5768-7505 ex 305 / +86 13601674297 China

Fax: +86 (21) 5768-7512Purity: Brand:

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD60/100mg () USD74/200mg ()

Shanghai RenYoung Pharmaceutical Co., Ltd. [email protected] +86 (21) 3501-0877 China

Fax: +86 (21) 3501-0877Purity: Brand:

Suzhou Unite Pharmtech Co., Ltd. [email protected],[email protected] +86 (512) 8766-6020 / +86 13222993784 China

Fax: +86 (512) 8217-7310Purity: Brand:

Taizhou Bolon Pharmachem Co., Ltd. [email protected] +86 (576) 8870-2852 China

Fax: +86 (576) 8855-9527Purity: Brand:

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD39/10mg () USD82/50mg () USD154/100mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

Fax: +1 (636) 207-7683Purity: #99 % Brand: Tocris

Yann Pharmachem Co., Ltd. [email protected] +86 (21) 6522-5530 China

Fax: +86 (21) 6522-5811Purity: Brand:

Zhejiang Dongdong Pharmaceutical Co., Ltd. [email protected] +86 (576) 8569-8599 China

Fax: Purity: Brand:

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Background Information of Bicalutamide

Bicalutamide(Casodex) is an oral non-steroidal anti-androgen for prostate cancer; binds to the androgen receptor.

Solubility of Bicalutamide

Solubility Sources
DMSO 86 mg/mL Water <1 mg/mL Ethanol 7mg/mL MedChemexpress Co., Ltd.
Soluble in DMSO, not in water MedKoo Biosciences, Inc.
(25°C) * In vitro DMSO 86 mg/mL (199.82 mM); Ethanol5 mg/mL (11.61 mM); Water<1 mg/mL (<1 mM) Selleck Chemicals LLC
Soluble to 100 mM in DMSO and to 10 mM in ethanol Tocris Bioscience Inc.

Storage Condition of Bicalutamide

Storage Condition Sources
Storage condition:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). Stock solution storage:0 - 4 C for short term (days to weeks), or -20 C for long term (months). Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. MedKoo Biosciences, Inc.
Store at RT Tocris Bioscience Inc.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [HNMR] MedChemexpress Co., Ltd.
[HPLC] [HNMR] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Autophagy Others
Target Androgen Receptor Autophagy
Research Area Cancer
Indications Hormone refractory prostate cancer Prostate tumor Metastatic prostate cancer

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Bicalutamide GlaxoSmithKline plc Hormone refractory prostate cancer 2007/5/31 2013/2/01 Phase 4 Clinical
Bicalutamide AstraZeneca plc Prostate tumor 2003/6/30 Phase 4 Clinical
Bicalutamide AstraZeneca plc Prostate tumor 2004/8/31 Phase 4 Clinical
Bicalutamide University of Tampere Prostate tumor 2004/10/31 2006/11/30 Phase 4 Clinical
Bicalutamide Ferring Pharmaceuticals Inc Metastatic prostate cancer 2009/4/30 2010/7/31 Phase 3 Clinical
Bicalutamide - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
430.37 C18H14F4N2O4S 90357-06-5 Cosudex;Casodex; N-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl)sulfonyl)-2-hydroxy-2-methylpropanamide

Structure Information of Bicalutamide

Smiles FC1=CC=C(S(=O)(CC(O)(C(NC2=CC=C(C#N)C(C(F)(F)F)=C2)=O)C)=O)C=C1
InChI InChI=1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)

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Safety Data of Bicalutamide

Hazard Symbols:Xi Risk Statements:36/37/38 Safety Statements:26-36
Transport Information: HS Code:29242995 RTECS:
WGK Germany:

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:191-193°C
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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