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DMXAA

(CAS: 117570-53-3)

Suppliers of DMXAA

Company Name Email Tel Country
AOBIOUS INC [email protected] (508) 306-0937 USA

Fax: Purity: Brand: AOBIOUS INC

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AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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Aladdin [email protected] 400 620 6333 China

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Alfa Chemistry [email protected] 1-201-478-8534 USA

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BOC Sciences [email protected] 1-631-504-6093

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BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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DC Chemicals [email protected]; [email protected] +86-21-58447131 China

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MAYA-R [email protected] 40066-10775 China

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD96/5mg () USD132/10mg ()
Quality Control & MSDS Files: LCMS HNMR MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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Price and Availability: USD2650/1g () USD3850/2g ()

ProbeChem [email protected] 86-21-80183644

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Santa Cruz Biotechnology, Inc. [email protected] Toll Free: 800-457-3801 Phone: 214-902-3900 USA

Fax: 214-358-6070Purity: Brand:

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: Brand:

Price and Availability: USD120/5mg (In stock) USD140/10mM/1mLIn DMSO (In stock) USD370/25mg (In stock) USD970/100mg (In stock)
Quality Control & MSDS Files: HPLC HNMR HPLC HPLC HNMR HPLC HNMR HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD96/5mg () USD132/10mg ()

Sigma-Aldrich, Inc. [email protected] +86 (21) 6141-5566 / 800-819-3336 USA

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Target Molecule Corp. [email protected] (857) 239-0968 USA

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Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

Fax: +1 (636) 207-7683Purity: Brand:

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Background Information of DMXAA

DMXAA, the vascular disrupting agent, is a murine agonist of the stimulator of interferon genes (STING) and also a potent inducer of type I IFNs and other cytokines.

Solubility of DMXAA

Solubility Sources
10 mM in DMSO CHEMSCENE, LLC
10 mM in DMSO MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 7 mg/mL (24.79 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM); In vivo 30% PEG400+0.5% Tween80+5% Propylene glycol30 mg/mL Selleck Chemicals LLC

Storage Condition of DMXAA

Storage Condition Sources
Store in a tightly closed container, in a cool and dry place. MedChemexpress Co., Ltd.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [HNMR] MedChemexpress Co., Ltd.
[HPLC] [HNMR] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Autophagy
Target Autophagy
Research Area Cancer
Indications Urothelial Carcinoma Non-Small Cell Lung Cancer Lung Cancer Prostate Cancer

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
DMXAA Hoosier Cancer Research Network Urothelial Carcinoma 2010/2/18 2015/8/01 Phase 2 Clinical
DMXAA Novartis Pharmaceuticals Non-Small Cell Lung Cancer 2008/8/19 2012/5/01 Phase 3 Clinical
DMXAA Swiss Group for Clinical Cancer Research Lung Cancer 2010/1/26 2013/4/01 Phase 2 Clinical
DMXAA Antisoma Research Prostate Cancer 2005/5/24 2009/1/01 Phase 2 Clinical
DMXAA - Phase 2

Chemical Information

M.Wt Formula CAS No. Synonyms
282.2906 C17H14O4 117570-53-3 ASA-404;Vadimezan

Structure Information of DMXAA

Smiles O=C(O)CC1=CC=CC(C2=O)=C1OC3=C2C=CC(C)=C3C
InChI InChI=1S/C17H14O4/c1-9-6-7-13-15(20)12-5-3-4-11(8-14(18)19)17(12)21-16(13)10(9)2/h3-7H,8H2,1-2H3,(H,18,19)

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Safety Data of DMXAA

Hazard Symbols:Xn,N Risk Statements:R22;R50/53 Safety Statements:S60;S61
Transport Information:UN 3077 HS Code: RTECS:ZD5536200
WGK Germany:3

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,7 mg/mL(24.79 mM);In vitro:Water,Insoluble;In vitro:Ethanol,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):5% NaHCO3 (aq) warmedFor best results, use promptly after mi
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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