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(CAS: 446859-33-2)

Suppliers of RepSox

Company Name Email Tel Country
AOBIOUS INC [email protected] (508) 306-0937 USA

Fax: Purity: Brand: AOBIOUS INC

Price and Availability: USD15/1mg ()

Active Biopharma Corp [email protected] +86 (571) 8161-2335 China

Fax: Purity: Brand:

Alfa Chemistry [email protected] 1-201-478-8534 USA

Fax: 1-516-927-0118Purity: 98%+ Brand: Alfa Chemistry

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: Brand: BOC Sciences

Price and Availability: USD198/100mg (In stock)

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD72/5mg () USD108/10mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD72/5mg () USD108/10mg ()
Quality Control & MSDS Files: LCMS HNMR MSDS

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: >98% Brand:

Price and Availability: USD147/10mg (In stock) USD270/25mg (In stock)
Quality Control & MSDS Files: HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD72/5mg () USD108/10mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD63/5mg () USD124/10mg () USD183/25mg () USD343/50mg ()

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Background Information of RepSox

RepSox(E-616452; SJN 2511) is a potent and selective inhibitor of the TGFβR-1/ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation, respectively. IC50 Value: 23 nM Target: ALK5 in vitro: Pretreated MEFs with RepSox, applying the chemical for three days, and then removed it at the time of transduction with Oct4, Klf4, and cMyc.

Solubility of RepSox

Solubility Sources
DMSO MedChemexpress Co., Ltd.
DMSO 57 mg/mL (198 mM) ; Water <1 mg/mL (<1 mM) ; Ethanol <1 mg/mL (<1 mM) Selleck Chemicals LLC

Storage Condition of RepSox

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [HNMR] MedChemexpress Co., Ltd.
[HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways TGF-beta/Smad
Target TGF-β Receptor
Research Area Cancer

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
RepSox - Not Found
RepSox - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
287.32 C17H13N5 446859-33-2 E-616452;SJN 2511;E616452;SJN2511;E 616452;SJN-2511; 2-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine

Structure Information of RepSox

Smiles CC1=NC(C2=NNC=C2C3=NC4=CC=CN=C4C=C3)=CC=C1
InChI InChI=1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22)

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Chemical and Physical Properties

Appearance:Light yellow to yellow Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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