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Sapitinib

(CAS: 848942-61-0)

Suppliers of Sapitinib

Company Name Email Tel Country
AOBIOUS INC [email protected] (508) 306-0937 USA

Fax: Purity: Brand: AOBIOUS INC

Price and Availability: USD21/1mg ()

AbMole BioScience [email protected] 1-800-660-8580 USA

Fax: Purity: Brand:

Price and Availability: USD240/10mg (In stock) USD680/50mg (In stock) USD980/100mg (In stock)

AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

Fax: 866-333-9607 (US & Canada Toll Free) +1-323-606-8156 (Outside of US & Canada)Purity: Brand:

Price and Availability: USD100/5mg () USD180/10mg () USD350/25mg () USD1200/100mg ()

Aladdin [email protected] 400 620 6333 China

Fax: 021 5102 6000Purity: Brand:

Price and Availability: RMB1299/5mg (4-8 weeks) RMB2299/10mg (4-8 weeks) RMB6899/50mg (4-8 weeks)

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: Brand:

Price and Availability: USD119/5mg (In stock) USD224/10mg (In stock) USD679/50mg (In stock)

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: 0.98 Brand: BOC Sciences

Beijing Lab-bio Ltd.

Fax: Purity: Brand:

Price and Availability: RMB1428/5mg ()

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

Price and Availability: USD204/5mg (In stock) USD330/10mg (In stock)

Biorbyt Ltd. [email protected] +44 (0)1223 859 353 UK

Fax: +44 (0)1223 280 240Purity: Brand:

Price and Availability: USD1020/100mg (5-10 working days) USD2040/500mg (5-10 working days) USD3400/1g (5-10 working days)

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD60/5mg () USD90/10mg ()

DC Chemicals [email protected]; [email protected] +86-21-58447131 China

Fax: +86-21-61642470Purity: Brand:

Price and Availability: USD900/100mg (In stock) USD1800/250mg (In stock) USD3600/1000mg (In stock)

KareBay Biochem [email protected] 732-823-1545 USA

Fax: 732-823-1349Purity: Brand:

Price and Availability: USD136/5mg () USD256/10mg () USD776/50mg () USD1976/200mg ()

Lancrix Chemicals. [email protected] 86 21 50817262 China

Fax: 86 21 57712035Purity: Brand:

Price and Availability: USD95/5mg () USD180/10mg () USD630/50mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD60/5mg () USD90/10mg ()
Quality Control & MSDS Files: LCMS HNMR MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: Brand:

Santa Cruz Biotechnology, Inc. [email protected] Toll Free: 800-457-3801 Phone: 214-902-3900 USA

Fax: 214-358-6070Purity: Brand:

Price and Availability: USD225/5mg () USD480/10mg ()

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: >98% Brand:

Price and Availability: USD170/5mg (In stock) USD320/10mM/1mLIn DMSO (In stock) USD320/10mM*1mLIn DMSO (In stock) USD320/10mg (In stock) USD970/50mg (In stock) USD2470/200mg (In stock)
Quality Control & MSDS Files: HPLC HNMR HPLC HNMR HPLC HNMR HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD60/5mg () USD90/10mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD71/2mg () USD110/5mg () USD169/10mg () USD268/25mg () USD498/50mg ()

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Background Information of Sapitinib

Sapitinib (AZD-8931) is a reversible, ATP competitive EGFR inhibitor of with IC50s of 4, 3 and 4 nM for EGFR, ErbB2 and ErbB3 in cells, respectively.

Solubility of Sapitinib

Solubility Sources
DMSO 40 mg/ml; Water < 1 mg/ml CHEMSCENE, LLC
DMSO 40 mg/ml; Water < 1 mg/ml MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 40 mg/mL (84.4 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM); In vivo 30% PEG400+0.5% Tween80+5% Propylene glycol5 mg/mL Selleck Chemicals LLC

Storage Condition of Sapitinib

Storage Condition Sources
4°C MedChemexpress Co., Ltd.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [HNMR] MedChemexpress Co., Ltd.
[HPLC] [HNMR] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways JAK/STAT Signaling Protein Tyrosine Kinase/RTK
Target EGFR
Research Area Cancer
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Sapitinib - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
473.93 C23H25ClFN5O3 848942-61-0 AZD 8931; 2-(4-((4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)-N-methylacetamide

Structure Information of Sapitinib

Smiles O=C(CN1CCC(OC2=CC3=C(NC4=CC=CC(Cl)=C4F)N=CN=C3C=C2OC)CC1)NC
InChI InChI=1S/C23H25ClFN5O3/c1-26-21(31)12-30-8-6-14(7-9-30)33-20-10-15-18(11-19(20)32-2)27-13-28-23(15)29-17-5-3-4-16(24)22(17)25/h3-5,10-11,13-14H,6-9,12H2,1-2H3,(H,26,31)(H,27,28,29)

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
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Vapour: EINECS:
Optical Rotation: alpha:

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