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(CAS: 627536-09-8)

Suppliers of SD-208

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Axon Medchem BV [email protected];[email protected] +31 50 3118007 Netherlands

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BOC Sciences [email protected] 1-631-504-6093

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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KareBay Biochem [email protected] 732-823-1545 USA

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Quality Control & MSDS Files: HNMR LCMS MSDS

Pure Chemistry Scientific Inc. [email protected] 857-928-2050 / 857-366-6788 USA

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Tocris Bioscience Inc. [email protected]; [email protected]com +1 (636) 207-7651 USA

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Background Information of SD-208

SD-208 is a potent, orally active ATP-competitive transforming growth factor-β receptor 1 (TGF-βRI) inhibitor (IC50= 49 nM); displays > 100-fold and > 17-fold selectivity over TGF-βRII and other common kinases respectively. IC50 value: 49 nM Target: TGF-βRI SD-208 is a potent, orally active TGF-βR I kinase inhibitor (TGF-βRI) with IC50 =49 nM based on direct enzymatic assay of TGFRI kinase (ALK5) activity with a specificity of >100-fold against TGFRII and at least 17-fold over members of a panel of related protein kinases including p38a, p38b, p38d, JNK1, EGFR, MAPKAPK2, MKK6, ERK2, PKC, PKA, PKD, CDC2, and CaMKII.

Solubility of SD-208

Solubility Sources
DMSO >10 mg/mL MedChemexpress Co., Ltd.

Storage Condition of SD-208

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways TGF-beta/Smad
Target TGF-β Receptor
Research Area Cancer

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
SD-208 - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
352.75 C17H10ClFN6 627536-09-8 SD 208; SD208; 2-(5-chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine

Structure Information of SD-208

Smiles FC1=CC=C(Cl)C=C1C2=NC3=NC=CN=C3C(NC4=CC=NC=C4)=N2
InChI InChI=1S/C17H10ClFN6/c18-10-1-2-13(19)12(9-10)15-24-16-14(21-7-8-22-16)17(25-15)23-11-3-5-20-6-4-11/h1-9H,(H,20,22,23,24,25)

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Chemical and Physical Properties

Appearance:yellow to yellow-brown solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density:1.487 Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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