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SD-208

(CAS: 627536-09-8)

Suppliers of SD-208

Company Name Email Tel Country
Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: Brand:

Price and Availability: USD118/10mg (Ship Within 10-14 Days) USD498/50mg (Ship Within 10-14 Days)

Axon Medchem BV [email protected];[email protected] +31 50 3118007 Netherlands

Fax: +31 50 3600390Purity: Brand:

Price and Availability: USD72/2mg (In Stock)

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: >98% Brand:

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

Fax: (734) 971-3640Purity: Brand:

Price and Availability: USD29/1mg ()

EMD Millipore USA

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Price and Availability: USD119/2mg ()

KareBay Biochem [email protected] 732-823-1545 USA

Fax: 732-823-1349Purity: Brand:

Price and Availability: USD125/10mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: >98% Brand:

Price and Availability: USD124/10mg (In stock) USD524/50mg (In stock)
Quality Control & MSDS Files: HNMR LCMS MSDS

Pure Chemistry Scientific Inc. [email protected] 857-928-2050 / 857-366-6788 USA

Fax: 617-206-9595Purity: 98% Brand:

Price and Availability: USD65/10mg (In stock)

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: >98% Brand:

Price and Availability: USD124/10mg (In stock) USD524/50mg (In stock)

Sigma-Aldrich, Inc. [email protected] +86 (21) 6141-5566 / 800-819-3336 USA

Fax: Purity: Brand:

Price and Availability: USD142/5mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD66/2mg () USD112/5mg () USD198/10mg () USD476/50mg () USD735/100mg ()

Tocris Bioscience Inc. [email protected] +1 (636) 207-7651 USA

Fax: +1 (636) 207-7683Purity: Brand:

Price and Availability: USD165/10mg ()

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Background Information of SD-208

SD-208 is a potent, orally active ATP-competitive transforming growth factor-β receptor 1 (TGF-βRI) inhibitor (IC50= 49 nM); displays > 100-fold and > 17-fold selectivity over TGF-βRII and other common kinases respectively. IC50 value: 49 nM Target: TGF-βRI SD-208 is a potent, orally active TGF-βR I kinase inhibitor (TGF-βRI) with IC50 =49 nM based on direct enzymatic assay of TGFRI kinase (ALK5) activity with a specificity of >100-fold against TGFRII and at least 17-fold over members of a panel of related protein kinases including p38a, p38b, p38d, JNK1, EGFR, MAPKAPK2, MKK6, ERK2, PKC, PKA, PKD, CDC2, and CaMKII.

Solubility of SD-208

Solubility Sources
DMSO >10 mg/mL MedChemexpress Co., Ltd.

Storage Condition of SD-208

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways TGF-beta/Smad
Target TGF-β Receptor
Research Area Cancer
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
SD-208 - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
352.75 C17H10ClFN6 627536-09-8 SD 208; SD208; 2-(5-chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine

Structure Information of SD-208

Smiles FC1=CC=C(Cl)C=C1C2=NC3=NC=CN=C3C(NC4=CC=NC=C4)=N2
InChI InChI=1S/C17H10ClFN6/c18-10-1-2-13(19)12(9-10)15-24-16-14(21-7-8-22-16)17(25-15)23-11-3-5-20-6-4-11/h1-9H,(H,20,22,23,24,25)

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Chemical and Physical Properties

Appearance:yellow to yellow-brown solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density:1.487 Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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