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Thalidomide

(CAS: 50-35-1)

Suppliers of Thalidomide

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A.G. Scientific, Inc. [email protected] 858 452 9925 USA

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AbMole BioScience [email protected] 1-800-660-8580 USA

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AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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Changzhou Hangyu Pharmaceutical Technology Co., Ltd. [email protected],[email protected] +86 (519) 8880-2789 / +86 13961196887 China

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Changzhou Kangzheng Pharmachem Technology Co., Ltd. [email protected] +86 (519) 8510-9938 China

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Changzhou Sanling Chemical Co., Ltd. [email protected],[email protected] +86 (519) 8873-1370 / +86 13921039671 China

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Datang (Hangzhou) Pharmachem Co., Ltd. [email protected] +86 (571) 8731-1096 China

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EMD Millipore USA

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LKT Laboratories Inc. [email protected] 1-888-LKT-LABS, 1-888-558-5227 USA

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD80/200mg () USD150/500mg ()
Quality Control & MSDS Files: MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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Microbiologica Quimica e Farmaceutica Ltda. [email protected] +55 (21) 3296-3200 Brazil

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Quzhou Rundong Chemical Co., Ltd. [email protected],[email protected] +86 (570) 878-9886 China

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Santa Cruz Biotechnology, Inc. [email protected] Toll Free: 800-457-3801 Phone: 214-902-3900 USA

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Price and Availability: USD86/100mg ()

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Price and Availability: USD147/200mg (In stock) USD190/10mM/1mLIn DMSO (In stock)
Quality Control & MSDS Files: HNMR HPLC HNMR HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Sigma-Aldrich, Inc. [email protected] +86 (21) 6141-5566 / 800-819-3336 USA

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Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

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Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

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Tokyo Chemical Industry Co., Ltd. [email protected] 03-3668-0489 Japan

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Toronto Research Chemicals Inc. [email protected] +1 (416) 665-9696 Canada

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VDM BIOCHEMICALS,Inc. [email protected] 1-440-786-9400 USA

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Xiangyang Jinsheng Pharmaceutical Co., Ltd. [email protected] +86 (710) 357-7774 China

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Background Information of Thalidomide

Thalidomide can directly inhibit angiogenesis induced by bFGF or VEGF in vivo. IC50 value: Target: Thalidomide was commonly used therapeutically in the late 1950's; however, it was withdrawn from the market when it was discovered to cause birth defects.

Solubility of Thalidomide

Solubility Sources
DMSO >20 mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 52 mg/mL (201.37 mM); Ethanol2 mg/mL (7.74 mM); Water<1 mg/mL (<1 mM); In vivo 30% PEG400+0.5% Tween80+5% Propylene glycol5 mg/mL Selleck Chemicals LLC

Storage Condition of Thalidomide

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Others
Target Others
Research Area Cancer
Indications Multiple myeloma Uveitis

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Thalidomide Second Military Medical University PLA Multiple myeloma 2010/6/30 2014/6/30 Phase 4 Clinical
Thalidomide PETHEMA Foundation Multiple myeloma 2007/1/31 2010/6/30 Phase 4 Clinical
Thalidomide University of Cincinnati Uveitis 2004/1/31 2006/8/31 Phase 4 Clinical
Thalidomide Millennium Pharmaceuticals Inc Multiple myeloma 2007/6/30 2013/5/31 Phase 3 Clinical
Thalidomide University of Arkansas Multiple myeloma 2006/11/30 2013/4/30 Phase 3 Clinical
Thalidomide - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
258.23 C13H10N2O4 50-35-1 2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione; 2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Structure Information of Thalidomide

Smiles O=C(C1=C2C=CC=C1)N(C2=O)C(CCC3=O)C(N3)=O
InChI InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)

Related Products

Other Form Products of Thalidomide

Name CAS Formula Suppliers
(S)-Thalidomide 841-67-8 C13H10N2O4 3
(R)-Thalidomide 2614-06-4 C13H10N2O4 3
Thalidomide (D4) 1219177-18-0 C13H6D4N2O4 3

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BAMB-4 891025-25-5 C15H12N2O2 8
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ITX3 347323-96-0 C22H17N3OS 10
Cardiogreen 3599-32-4 C43H47N2NaO6S2 8
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INH1 313553-47-8 C18H16N2OS 12
PF6-AM 1268491-69-5 C33H31BO12 4
XEN445 1515856-92-4 C18H17F3N2O3 21
Disperse Blue 148 52239-04-0 C19H19N5O4S 5
Solvent Blue 35 17354-14-2 C22H26N2O2 6
CID-797718 370586-05-3 C12H11NO3 12

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Panobinostat 404950-80-7 C21H23N3O2 21
Carfilzomib 868540-17-4 C40H57N5O7 22
ARRY-520 (R enantiomer) 885060-08-2 C20H22F2N4O2S 8
ARRY-520 885060-09-3 C20H22F2N4O2S 14
Delanzomib 847499-27-8 C21H28BN3O5 18
RO4929097 847925-91-1 C22H20F5N3O3 16
Erastin 571203-78-6 C30H31ClN4O4 20
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Danusertib 827318-97-8 C26H30N6O3 10
Masitinib 790299-79-5 C28H30N6OS 19
Pomalidomide 19171-19-8 C13H11N3O4 22
Lenalidomide 191732-72-6 C13H13N3O3 24
PHA-680632 398493-79-3 C28H35N7O2 15
INK-128 1224844-38-5 11
Lenalidomide (hydrochloride) 1243329-97-6 C13H14ClN3O3 6
AVN-944 297730-17-7 C25H27N5O5 13
Vorinostat 149647-78-9 C14H20N2O3 31

Safety Data of Thalidomide

Hazard Symbols:T Risk Statements:R46;R61;R21;R25;R62 Safety Statements:S53;S22;S26;S36/37/39;S45
Transport Information:UN 2811 HS Code: RTECS:TI4375000
WGK Germany:3

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:269-271°C
Boiling point: Flash Point:
Water Solubility: <0.1 g/100 mL at 22 ºC Solubility:In vitro:DMSO,51 mg/mL(197.49 mM);In vitro:Ethanol,2 mg/mL(7.74 mM);In vitro:Water,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):5% DMSO+30% PEG 300+1% Tween 80+ddH2O (suspension)F
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:200-031-1
Optical Rotation: alpha:

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