• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

Ruxolitinib

(CAS: 941678-49-5)

Suppliers of Ruxolitinib

Company Name Email Tel Country
AOBIOUS INC [email protected] (508) 306-0937 USA

Fax: Purity: Brand: AOBIOUS INC

Price and Availability: USD17/1mg ()

Alfa Chemistry [email protected] 1-201-478-8534 USA

Fax: 1-516-927-0118Purity: 0.96 Brand: Alfa Chemistry

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: 98% Brand: Tocris

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: > 95% Brand: BOC Sciences

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD72/5mg () USD84/10mg ()

ChemieTek [email protected] +1 (317) 598-0828 USA

Fax: +1 (317) 598-0835Purity: Brand:

LC Laboratoies [email protected] +1-781-937-0777 +1-800-937-3720 in US and Canada only USA

Fax: +1-781-938-5420Purity: >99% Brand:

Price and Availability: USD69/10mg (In stock) USD99/25mg (In stock) USD138/50mg (In stock) USD234/100mg (In stock) USD417/200mg (In stock) USD829/500mg (In stock) USD1382/1g (In stock)

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD72/5mg () USD84/10mg ()
Quality Control & MSDS Files: LCMS NP-HPLC HNMR MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: >98% Brand:

Quality Control & MSDS Files: CoA HNMR LCMS ChiralHPLC MSDS

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: >98% Brand:

Price and Availability: USD160/5mg (In stock) USD208/10mM/1mLIn DMSO (In stock) USD230/10mg (In stock) USD320/25mg (In stock) USD800/100mg (In stock)
Quality Control & MSDS Files: HPLC HNMR HPLC HPLC HPLC HPLC HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD72/5mg () USD84/10mg ()

Taizhou Crene Biotechnology Co., Ltd. [email protected] +86 (576) 8881-3233 / 8820-5808 / +86 13396860566 China

Fax: +86 (576) 8822-9589Purity: Brand:

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD56/1mg () USD155/5mg () USD275/10mg () USD488/25mg ()

Inquiry Online

Salutation: *Country:
*Customer: *Company Name:
*Email: *Request quantity:
Remarks:
 

Notice: Your contact information will be sent to selected suppliers.

* Required Fields.

Background Information of Ruxolitinib

Ruxolitinib(INCB018424) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3.

Solubility of Ruxolitinib

Solubility Sources
Soluble in DMSO > 10 mM Apexbio Technology LLC
Soluble in DMSO at 28 mg/mL; soluble in ethanol at 15 mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 25-50 μM; buffers, serum, or other additives may increase or decrease the aqueous solubility. LC Laboratoies
DMSO 60 mg/mL Water <1 mg/mL Ethanol 60 mg/mL MedChemexpress Co., Ltd.
Soluble in DMSO, not in water MedKoo Biosciences, Inc.
(25°C) * In vitro DMSO 61 mg/mL (199.1 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM); In vivo 2% DMSO+30% PEG 300+ddH2O5mg/mL Selleck Chemicals LLC

Storage Condition of Ruxolitinib

Storage Condition Sources
Store at -20°C Apexbio Technology LLC
Store at or below -20 oC. LC Laboratoies
Storage condition:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). Stock solution storage:0 - 4 C for short term (days to weeks), or -20 C for long term (months). Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. MedKoo Biosciences, Inc.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.
MedKoo Biosciences, Inc.

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [NP-HPLC] [HNMR] MedChemexpress Co., Ltd.
[CoA] [HNMR] [LCMS] [ChiralHPLC] MedKoo Biosciences, Inc.
[HPLC] [HNMR] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways JAK/STAT Signaling Autophagy Epigenetics Stem Cell/Wnt
Target JAK Autophagy
Research Area Cancer
Indications Myelofibrosis Leukemia Polycythemia vera

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Ruxolitinib Novartis AG Myelofibrosis 2012/5/31 2013/11/30 Phase 4 Clinical
Ruxolitinib Novartis AG Myelofibrosis 2011/8/31 2015/12/31 Phase 4 Clinical
Ruxolitinib Gilead Sciences Inc Myelofibrosis 2013/10/31 2017/10/31 Phase 3 Clinical
Ruxolitinib MD Anderson Cancer Center Leukemia 2013/3/31 2015/3/31 Phase 3 Clinical
Ruxolitinib Incyte Corp Polycythemia vera 2012/6/30 2014/5/31 Phase 3 Clinical
Ruxolitinib - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
306.37 C17H18N6 941678-49-5 INCB 018424;INCB018424;INCB-018424; (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile

Structure Information of Ruxolitinib

Smiles N#CC[[email protected]](C1CCCC1)N2N=CC(C3=C4C=CNC4=NC=N3)=C2
InChI InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1

Related Products

Other Form Products of Ruxolitinib

Name CAS Formula Suppliers
Ruxolitinib (S enantiomer) 941685-37-6 C17H18N6 14
Ruxolitinib (sulfate) 1092939-16-6 C17H20N6O4S 6
Ruxolitinib (phosphate) 1092939-17-7 C17H21N6O4P 16

Recommended Products in Same Target

Name CAS Formula Suppliers
Cerdulatinib 1198300-79-6 C20H27N7O3S 14
Ruxolitinib (S enantiomer) 941685-37-6 C17H18N6 14
GLPG0634 analog 1206101-20-3 C23H18N6O2 14
WHI-P154 211555-04-3 C16H14BrN3O3 21
Baricitinib (phosphate) 1187595-84-1 C16H20N7O6PS 16
Diosgenin 512-04-9 C27H42O3 34
XL019 945755-56-6 C25H28N6O2 17
GLPG0634 1206161-97-8 C21H23N5O3S 24
Oclacitinib 1208319-26-9 C15H23N5O2S 11
(3R,4S)-Tofacitinib 1092578-46-5 C16H20N6O 8
(3S,4S)-Tofacitinib 1092578-47-6 C16H20N6O 8
(3S,4R)-Tofacitinib 1092578-48-7 C16H20N6O 7
JANEX-1 202475-60-3 C16H15N3O3 17
NSC 42834 195371-52-9 C23H24N2O 16
Tofacitinib (citrate) 540737-29-9 C22H28N6O8 22
Pacritinib 937272-79-2 C28H32N4O3 18
CEP-33779 1257704-57-6 C24H26N6O2S 16
Baricitinib 1187594-09-7 C16H17N7O2S 21
WP1066 857064-38-1 C17H14BrN3O 20
BMS-911543 1271022-90-2 C23H28N8O 21

Recommended Products in the Same Indication

Name CAS Formula Suppliers
5-Azacytidine 320-67-2 C8H12N4O5 26
Pomalidomide 19171-19-8 C13H11N3O4 22
Triciribine 35943-35-2 C13H16N6O4 19
Dexrazoxane (Hydrochloride) 149003-01-0 C11H17ClN4O4 16
CYT387 1056634-68-4 C23H22N6O2 11
CYT387 (sulfate salt) 1056636-06-6 C23H26N6O10S2 9
CYT387 (Mesylate) 1056636-07-7 C24H26N6O5S 6
LY2784544 1229236-86-5 C23H25ClFN7O 18
Zosuquidar 167354-41-8 C32H31F2N3O2 6
Perifosine 157716-52-4 C25H52NO4P 19
Ruxolitinib (sulfate) 1092939-16-6 C17H20N6O4S 6
Ruxolitinib (phosphate) 1092939-17-7 C17H21N6O4P 16
Pracinostat 929016-96-6 C20H30N4O2 17
SGI-110 929901-49-5 C18H24N9O10P 10
TG101209 936091-14-4 C26H35N7O2S 16
TG-101348 936091-26-8 C27H36N6O3S 15
Pacritinib 937272-79-2 C28H32N4O3 18
AMG 900 945595-80-2 C28H21N7OS 16
LY2510924 1088715-84-7 C62H88N14O10 8
BAY-1143572 Racemate 1414943-88-6 C18H18FN5O2S 5

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density:1.40 Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

Tags: buy Ruxolitinib | Ruxolitinib IC50 | Ruxolitinib price | Ruxolitinib cost | Ruxolitinib solubility | Ruxolitinib purchase | Ruxolitinib manufacturer | Ruxolitinib research buy | Ruxolitinib order | Ruxolitinib MSDS | Ruxolitinib chemical structure | Ruxolitinib Storage condition | Ruxolitinib molecular weight | Ruxolitinib mw | Ruxolitinib datasheet | Ruxolitinib supplier | Ruxolitinib cell line | Ruxolitinib NMR | Ruxolitinib MS | Ruxolitinib IR | Ruxolitinib solubility | Ruxolitinib Safe information | Ruxolitinib Qc and Spectral Information | Ruxolitinib Clinical Information | Ruxolitinib Clinical Trial | Ruxolitinib Route of Synthesis | Ruxolitinib storage condition | Ruxolitinib diseases and conditions | Ruxolitinib flash point | Ruxolitinib boiling point | Ruxolitinib melting point | Ruxolitinib storage condition | Ruxolitinib brand