• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

AT7519 (Hydrochloride)

(CAS: 902135-91-5)

Suppliers of AT7519 (Hydrochloride)

Company Name Email Tel Country
AOBIOUS INC [email protected] (508) 306-0937 USA

Fax: Purity: Brand:

AOBIOUS INC [email protected] (508) 306-0937 USA

Fax: Purity: Brand:

AbMole BioScience [email protected] 1-800-660-8580 USA

Fax: Purity: Brand:

Price and Availability: USD90/5mg (In stock)

Abcam [email protected] (888) 77-ABCAM (22226) USA

Fax: (877) 774-8286 / (617) 577-4201Purity: Brand:

Price and Availability: USD235/10mg ()

Adipogen Corporation [email protected] (858) 457-8383 USA

Fax: (858) 457-8484Purity: Brand:

AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

Fax: 866-333-9607 (US & Canada Toll Free) +1-323-606-8156 (Outside of US & Canada)Purity: Brand:

Price and Availability: USD95/5mg ()

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: Brand:

Price and Availability: USD147/10mg (Ship Within 10-14 Days)

Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

Fax: +1 (847) 367-3681Purity: Brand:

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: Brand: BOC Sciences

Price and Availability: USD178/10mg (In stock)

BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

Fax: 408-493-1801Purity: Brand:

Price and Availability: USD95/5mg ()

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD60/5mg () USD90/10mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

Fax: (734) 971-3640Purity: Brand:

Price and Availability: USD25/1mg ()

Hebei Corol Fine Chemical Co., Ltd. [email protected],[email protected] +86 (311) 8983-7599 / +86 13930126797 China

Fax: +86 (10) 5720-2325Purity: Brand:

Lancrix Chemicals. [email protected] 86 21 50817262 China

Fax: 86 21 57712035Purity: Brand:

Price and Availability: USD135/10mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD60/5mg () USD90/10mg ()
Quality Control & MSDS Files: MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: Brand:

Price and Availability: USD150/5mg ()
Quality Control & MSDS Files: CoA HNMR LCMS MSDS

ProbeChem [email protected] 86-21-80183644

Fax: 86-21-68860190Purity: Brand:

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: Brand:

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD60/5mg () USD90/10mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD87/5mg () USD181/20mg () USD307/50mg () USD422/100mg ()

Inquiry Online

Salutation: *Country:
*Customer: *Company Name:
*Email: *Request quantity:
Remarks:
 

Notice: Your contact information will be sent to selected suppliers.

* Required Fields.

Background Information of AT7519 (Hydrochloride)

AT7519 hydrochloride is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM; is less potent to CDK3 and little active to CDK7.

Solubility of AT7519 (Hydrochloride)

Solubility Sources
DMSO MedChemexpress Co., Ltd.
Soluble in DMSO, not in water MedKoo Biosciences, Inc.

Storage Condition of AT7519 (Hydrochloride)

Storage Condition Sources
Storage condition:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). Stock solution storage:0 - 4 C for short term (days to weeks), or -20 C for long term (months). Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. MedKoo Biosciences, Inc.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.
MedKoo Biosciences, Inc.

Quality Control and Spectral Data

QC Reports Sources
[CoA] [HNMR] [LCMS] MedKoo Biosciences, Inc.

Mechanism and Indications

Signaling Pathways Cell Cycle/DNA Damage
Target CDK
Research Area Cancer
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
AT7519 (Hydrochloride) - Phase 2 Clinical
AT7519 (Hydrochloride) - Phase 2

Chemical Information

M.Wt Formula CAS No. Synonyms
418.71 C16H18Cl3N5O2 902135-91-5 AT 7519 Hydrochloride;AT-7519 Hydrochloride; 4-(2,6-dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide hydrochloride

Structure Information of AT7519 (Hydrochloride)

Smiles O=C(C(C(Cl)=CC=C1)=C1Cl)NC2=CNN=C2C(NC3CCNCC3)=O.[H]Cl
InChI InChI=1S/C16H17Cl2N5O2.ClH/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9;/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24);1H

Related Products

Other Form Products of AT7519 (Hydrochloride)

Name CAS Formula Suppliers
AT7519 (trifluoroacetate) 1431697-85-6 C18H18Cl2F3N5O4 9
AT7519 844442-38-2 C16H17Cl2N5O2 13

Recommended Products in Same Target

Name CAS Formula Suppliers
LY2857785 1619903-54-6 C26H36N6O 12
THZ2 1604810-84-5 C31H28ClN7O2 10
Palbociclib (isethionate) 827022-33-3 C26H35N7O6S 22
CDK9-IN-6 1391855-95-0 C27H37ClN6O2 5
ML167 1285702-20-6 C19H17N3O3 15
AMG 925 1401033-86-0 C26H29N7O2 15
LDC000067 1073485-20-7 C18H18N4O3S 11
LEE011 (succinate hydrate) 1374639-79-8 C27H38N8O6X 8
LEE011 (succinate) 1374639-75-4 C27H36N8O5 9
LEE011 (hydrochloride) 1211443-80-9 C23H31ClN8O 8
LEE011 1211441-98-3 C23H30N8O 21
WHI-P180 (hydrochloride) 153437-55-9 C16H16ClN3O3 6
Wogonin 632-85-9 C16H12O5 28
1-NM-PP1 221244-14-0 C20H21N5 17
WHI-P180 211555-08-7 C16H15N3O3 13
THZ1 1604810-83-4 C31H28ClN7O2 18
Senexin A 1366002-50-7 C17H14N4 8
CDK4-IN-1 1256963-02-6 C22H29ClN8 9
Palbociclib (hydrochloride) 827022-32-2 C24H30ClN7O2 16
Purvalanol B 212844-54-7 C20H25ClN6O3 22

Recommended Products in the Same Indication

Name CAS Formula Suppliers

Chemical and Physical Properties

Appearance:White to off-white solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,52 mg/mLwarmed(124.19 mM);In vitro:Water,43 mg/mLwarmed(102.69 mM);In vitro:Ethanol,28 mg/mLwarmed(66.87 mM);In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):SalineFor best result
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

Reference

[1].Alessandri AL, Duffin R, Leitch AE, Lucas CD, Sheldrake TA, Dorward DA, Hirani N, Pinho V, de Sousa LP, Teixeira MM, Lyons JF, Haslett C, Rossi AG. Induction of eosinophil apoptosis by the cyclin-dependent kinase inhibitor AT7519 promotes the resolution of eosinophil-dominant allergic inflammation. PLoS One. 2011;6(9):e25683.

[2].Mahadevan D, Plummer R, Squires MS, Rensvold D, Kurtin S, Pretzinger C, Dragovich T, Adams J, Lock V, Smith DM, Von Hoff D, Calvert H. A phase I pharmacokinetic and pharmacodynamic study of AT7519, a cyclin-dependent kinase inhibitor in patients with refractory solid tumors. Ann Oncol. 2011 Sep;22(9):2137-43.

[3].Squires MS, Cooke L, Lock V, Qi W, Lewis EJ, Thompson NT, Lyons JF, Mahadevan D. AT7519, a cyclin-dependent kinase inhibitor, exerts its effects by transcriptional inhibition in leukemia cell lines and patient samples. Mol Cancer Ther. 2010 Apr;9(4):920-8.

[4].Santo L, Vallet S, Hideshima T, Cirstea D, Ikeda H, Pozzi S, Patel K, Okawa Y, Gorgun G, Perrone G, Calabrese E, Yule M, Squires M, Ladetto M, Boccadoro M, Richardson PG, Munshi NC, Anderson KC, Raje N. AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3beta activation and RNA polymerase II inhibition. Oncogene. 2010 Apr 22;29(16):2325-36.

[5].Squires MS, Feltell RE, Wallis NG, Lewis EJ, Smith DM, Cross DM, Lyons JF, Thompson NT. Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines. Mol Cancer Ther. 2009 Feb;8(2):324-32.

Tags: buy AT7519 (Hydrochloride) | AT7519 (Hydrochloride) IC50 | AT7519 (Hydrochloride) price | AT7519 (Hydrochloride) cost | AT7519 (Hydrochloride) solubility | AT7519 (Hydrochloride) purchase | AT7519 (Hydrochloride) manufacturer | AT7519 (Hydrochloride) research buy | AT7519 (Hydrochloride) order | AT7519 (Hydrochloride) MSDS | AT7519 (Hydrochloride) chemical structure | AT7519 (Hydrochloride) Storage condition | AT7519 (Hydrochloride) molecular weight | AT7519 (Hydrochloride) mw | AT7519 (Hydrochloride) datasheet | AT7519 (Hydrochloride) supplier | AT7519 (Hydrochloride) cell line | AT7519 (Hydrochloride) NMR | AT7519 (Hydrochloride) MS | AT7519 (Hydrochloride) IR | AT7519 (Hydrochloride) solubility | AT7519 (Hydrochloride) Safe information | AT7519 (Hydrochloride) Qc and Spectral Information | AT7519 (Hydrochloride) Clinical Information | AT7519 (Hydrochloride) Clinical Trial | AT7519 (Hydrochloride) Route of Synthesis | AT7519 (Hydrochloride) storage condition | AT7519 (Hydrochloride) diseases and conditions | AT7519 (Hydrochloride) flash point | AT7519 (Hydrochloride) boiling point | AT7519 (Hydrochloride) melting point | AT7519 (Hydrochloride) storage condition | AT7519 (Hydrochloride) brand