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Agomelatine

(CAS: 138112-76-2)

Suppliers of Agomelatine

Company Name Email Tel Country
AA Blocks LLC [email protected] +1 858-523-8231

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AOBIOUS INC [email protected] (508) 306-0937 USA

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AbMole BioScience [email protected] 1-800-660-8580 USA

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Abcam [email protected] (888) 77-ABCAM (22226) USA

Fax: (877) 774-8286 / (617) 577-4201Purity: Brand:

Price and Availability: USD75/50mg ()

AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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Astatech, Inc. [email protected] +1 (215) 785-3197 USA

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Axon Medchem BV [email protected]hem.com;[email protected] +31 50 3118007 Netherlands

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Carbosynth Limited [email protected] +44 (1635) 578-444

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Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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Chem-Cook Chemicals Ltd. [email protected] +86 (23) 6253-9363 / +86 13657620624 China

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Chengdu Miracle Chemicals Co., Ltd. [email protected] +86 (28) 8613-6736 China

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Chengdu Sino-Strong Pharmaceutical Co., Ltd. [email protected],[email protected] +86 (28) 8278-3659 China

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Clearsynth Labs Limited [email protected] Worldwide Helpline No. +1-415-685-4395; US & Canada (Toll-free) : +1-800-650-8239; Europe : +44-20-3286-0885; India : +91-22-26355700 India

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Cooper Chemical Co., Ltd. [email protected] +86 18600011762 China

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Datang (Hangzhou) Pharmachem Co., Ltd. [email protected] +86 (571) 8731-1096 China

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Hangzhou Bm Chemical Co., Ltd. [email protected] +86 (571) 8733-0289 China

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD66/5mg () USD106/10mg ()
Quality Control & MSDS Files: LCMS HNMR MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: Brand:

Price and Availability: USD50/10mg ()

Nanjing Pharmaluxury Co., Ltd. [email protected] +86 (25) 8178-7427 China

Fax: +86 (25) 8372-6959Purity: Brand:

ProbeChem [email protected] 86-21-80183644

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Santa Cruz Biotechnology, Inc. [email protected] Toll Free: 800-457-3801 Phone: 214-902-3900 USA

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: Brand:

Price and Availability: USD97/10mg (In stock) USD130/10mM/1mLIn DMSO (In stock) USD163/10mM(in 1mL DMSO) (in 1mL DMSO) USD310/50mg (In stock) USD470/100mg (In stock)
Quality Control & MSDS Files: HNMR HPLC HNMR HPLC

Shanghai DND Pharm-Technology Co., Inc. [email protected],[email protected] +86 (21) 5878-3620 / 5878-3570 ex 8011 China

Fax: +86 (21) 5878-3595 ex 8003Purity: Brand:

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD66/5mg () USD106/10mg ()

Shangyu Zhebang Pharmaceutical Co., Ltd. [email protected] +86 (575) 8273-2308 China

Fax: +86 (575) 8272-8901Purity: Brand:

Sigma-Aldrich, Inc. [email protected] +86 (21) 6141-5566 / 800-819-3336 USA

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Price and Availability: USD60/5mg ()

Taizhou Jiakang Chemical Co., Ltd. [email protected],[email protected] +86 (576) 8822-6722 China

Fax: +86 (576) 8326-2826Purity: Brand:

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .99 Brand: TargetMol

Price and Availability: USD36/2mg () USD62/10mg () USD145/50mg ()

Tokyo Chemical Industry Co., Ltd. [email protected] 03-3668-0489 Japan

Fax: 03-3668-0520Purity: Brand:

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Toronto Research Chemicals Inc. [email protected] +1 (416) 665-9696 Canada

Fax: +1 (416) 665-4439Purity: Brand:

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Wuhan ChemFaces Biochemical Co., Ltd. [email protected]; [email protected] +86-27-84254680 China

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Wuhan Sunrise Technology Development Company Limited [email protected],[email protected] +86 (27) 8331-4682 / +86 13554138826 China

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Xuzhou Bestenchem Technology Co., Ltd [email protected] 13705205500 13952161236 CHINA

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Youth (Shanghai) Chemical Technology Co., Ltd. [email protected] +86 (21) 6486-7909 China

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Background Information of Agomelatine

Agomelatine is a competitive antagonist of human and porcine serotonin (5-HT2C) receptors (pKi = 6.2 and 6.4, respectively) as well as human 5-HT2B receptors (pKi = 6.6).

Solubility of Agomelatine

Solubility Sources
DMSO ≥49mg/mL Water <1mg/mL Ethanol ≥49mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 49 mg/mL (201.39 mM); Ethanol49 mg/mL (201.39 mM); Water<1 mg/mL (<1 mM) Selleck Chemicals LLC

Storage Condition of Agomelatine

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [HNMR] MedChemexpress Co., Ltd.
[HNMR] [HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Neuronal Signaling GPCR/G Protein
Target 5-HT Receptor
Research Area Neurological Disease
Indications Depression

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Agomelatine - Launched
Agomelatine Novartis AG Depression 2010/5/31 Phase 3 Clinical
Agomelatine Central Institute of Mental Health Depression 2013/1/31 2014/12/31 Phase 4 Clinical
Agomelatine Baker IDI Heart & Diabetes Institute Holdings Ltd Depression 2012/9/30 2015/2/28 Phase 4 Clinical
Agomelatine H Lundbeck A/S Depression 2012/1/31 Phase 3 Clinical
Agomelatine Novartis AG Depression 2010/6/30 2011/10/01 Phase 3 Clinical

Chemical Information

M.Wt Formula CAS No. Synonyms
243.3 C15H17NO2 138112-76-2 N-(2-(7-Methoxynaphth-1-yl)ethyl)acetamide; N-(2-(7-methoxynaphthalen-1-yl)ethyl)acetamide

Structure Information of Agomelatine

Smiles COC1=CC(C(CCNC(C)=O)=CC=C2)=C2C=C1
InChI InChI=1S/C15H17NO2/c1-11(17)16-9-8-13-5-3-4-12-6-7-14(18-2)10-15(12)13/h3-7,10H,8-9H2,1-2H3,(H,16,17)

Related Products

Other Form Products of Agomelatine

Name CAS Formula Suppliers
Agomelatine (L(+)-Tartaric acid) 824393-18-2 C19H23NO8 7
Agomelatine (hydrochloride) 1176316-99-6 C15H18ClNO2 8
Agomelatine (D6) 1079389-42-6 C15H11D6NO2 2

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Vilazodone (Hydrochloride) 163521-08-2 C26H28ClN5O2 13
Vilazodone (Hydrochloride) 163521-08-2 C26H28ClN5O2 20
Quetiapine (fumarate) 111974-72-2 C46H54N6O8S2 23
Pramipexole (dihydrochloride) 104632-25-9 C10H19Cl2N3S 31
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Vortioxetine (hydrobromide) 960203-27-4 C18H23BrN2S 13
Scopolamine 51-34-3 C17H21NO4 9

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:107-109°C
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,48 mg/mL(197.28 mM);In vitro:Ethanol,48 mg/mL(197.28 mM);In vitro:Water,Insoluble;
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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