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Lurasidone (Hydrochloride)

(CAS: 367514-88-3)

Suppliers of Lurasidone (Hydrochloride)

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AOBIOUS INC [email protected] (508) 306-0937 USA

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Beijing Mesochem Technology Co., Ltd. [email protected],[email protected] +86 (10) 6540-5760 / 6737-4028 / +86 13366977697 China

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Lanzhou Boc Chemical Co., Ltd. [email protected],[email protected] +86 (21) 3497-6665 ex 801 China

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Quality Control & MSDS Files: LCMS HNMR MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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Santa Cruz Biotechnology, Inc. [email protected] Toll Free: 800-457-3801 Phone: 214-902-3900 USA

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Shanghai Famo Bio-chemical Technology Company Ltd. [email protected],[email protected] +86 (21) 6816-0314 China

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Shanghai Sinoflychem Co., Ltd. [email protected],[email protected] +86 (21) 3530-3826 China

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Thode Laboratories [email protected] 1-416-8007660 Canada

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ZHIYU Biotechnology Co., Ltd. [email protected],[email protected] +86 (512) 6279-1916 / +86 18912796596 China

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Background Information of Lurasidone (Hydrochloride)

Lurasidone Hcl (SM 13496 Hcl) is an inhibitor of Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C with IC50 of 1.68 nM, 2.03 nM, 0.495 nM, 6.75 nM and 10.8 nM, respectively. IC50 Value: 1.68 nM(Dopamine D2); 2.03 nM(5-HT2A); 0.495 nM(5-HT7); 6.75 nM(5-HT1A); 10.8 nM (noradrenaline α2C) Target: 5-HT Receptor; Dopamine Receptor in vitro: Lurasidone antagonizes dopamine-stimulated [35S]GTPγS binding at human dopamine D2L receptor in a concentration-dependent manner with a KB value of 2.8 nM.

Solubility of Lurasidone (Hydrochloride)

Solubility Sources
DMSO 1 mg/mL; Water <1 mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 1 mg/mL (1.88 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) Selleck Chemicals LLC

Storage Condition of Lurasidone (Hydrochloride)

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [HNMR] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Neuronal Signaling GPCR/G Protein
Target Dopamine Receptor 5-HT Receptor
Research Area Neurological Disease
Indications Mania Schizophrenia Bipolar I disorder

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Lurasidone (Hydrochloride) Massachusetts General Hospital Mania 2013/10/31 2018/7/31 Phase 4 Clinical
Lurasidone (Hydrochloride) Northwestern University Schizophrenia 2011/10/31 2014/4/01 Phase 4 Clinical
Lurasidone (Hydrochloride) Dainippon Sumitomo Pharma Co Ltd Bipolar I disorder 2013/11/30 2017/9/30 Phase 3 Clinical
Lurasidone (Hydrochloride) Dainippon Sumitomo Pharma Co Ltd Bipolar I disorder 2013/11/30 2016/9/30 Phase 3 Clinical
Lurasidone (Hydrochloride) University of California Irvine Schizophrenia 2008/12/31 2013/10/31 Phase 3 Clinical
Lurasidone (Hydrochloride) - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
529.14 C28H37ClN4O2S 367514-88-3 SM 13496;SM13496;SM-13496; (3aR,4S,7R,7aS)-2-(((1R,2R)-2-((4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)methyl)cyclohexyl)methyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione hydrochloride

Structure Information of Lurasidone (Hydrochloride)

Smiles O=C([[email protected]]([[email protected]]1CC[[email protected]@H]2C1)[[email protected]]2C3=O)N3C[[email protected]@H]4CCCC[[email protected]]4CN(CC5)CCN5C6=NSC7=CC=CC=C76.Cl
InChI InChI=1S/C28H36N4O2S.ClH/c33-27-24-18-9-10-19(15-18)25(24)28(34)32(27)17-21-6-2-1-5-20(21)16-30-11-13-31(14-12-30)26-22-7-3-4-8-23(22)35-29-26;/h3-4,7-8,18-21,24-25H,1-2,5-6,9-17H2;1H/t18-,19+,20-,21-,24+,25-;/m0./s1

Related Products

Other Form Products of Lurasidone (Hydrochloride)

Name CAS Formula Suppliers
Lurasidone 367514-87-2 C28H36N4O2S 13

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Chemical and Physical Properties

Appearance:White to off-white solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,1 mg/mL(1.88 mM);In vitro:Water,Insoluble;In vitro:Ethanol,Insoluble;
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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