• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

ARN-509

(CAS: 956104-40-8)

Suppliers of ARN-509

Company Name Email Tel Country
AbMole BioScience [email protected] 1-800-660-8580 USA

Fax: Purity: Brand:

Price and Availability: USD150/10mg (In stock)

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: Brand:

Price and Availability: USD108/5mg (In stock)

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: 0.98 Brand: BOC Sciences

BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

Fax: 408-493-1801Purity: Brand:

Price and Availability: USD115/5mg ()

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD84/5mg () USD144/10mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

Fax: (734) 971-3640Purity: Brand:

Price and Availability: USD35/1mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD84/5mg () USD144/10mg ()
Quality Control & MSDS Files: HNMR LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: >98% Brand:

Price and Availability: USD150/10mg ()
Quality Control & MSDS Files: CoA HNMR HPLC MS MSDS

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: >98% Brand:

Price and Availability: USD210/5mg (In stock) USD270/10mg (In stock) USD400/10mM/1mLIn DMSO (In stock) USD504/10mM(in 1mL DMSO) (in 1mL DMSO) USD970/50mg (In stock) USD1270/100mg (In stock)
Quality Control & MSDS Files: HPLC HNMR HPLC HNMR HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD84/5mg () USD144/10mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD124/10mg () USD339/50mg ()

Inquiry Online

Salutation: *Country:
*Customer: *Company Name:
*Email: *Request quantity:
Remarks:
 

Notice: Your contact information will be sent to selected suppliers.

* Required Fields.

Background Information of ARN-509

ARN-509 is a selective and competitive androgen receptor inhibitor with IC50 of 16 nM, useful for prostate cancer treatment. IC50 value: 16 nM Target: androgen receptor ARN-509 is an androgen receptor antagonist with potential antineoplastic activity.

Solubility of ARN-509

Solubility Sources
DMSO 15 mg/mL Ethanol 5 mg/mL MedChemexpress Co., Ltd.
Soluble in DMSO, not in water MedKoo Biosciences, Inc.
(25°C) * In vitro DMSO 18 mg/mL (37.7 mM); Ethanol5 mg/mL (10.47 mM); Water<1 mg/mL (<1 mM); In vivo 0.5% CMC, pH4.014 mg/mL Selleck Chemicals LLC

Storage Condition of ARN-509

Storage Condition Sources
Storage condition:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). Stock solution storage:0 - 4 C for short term (days to weeks), or -20 C for long term (months). Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. MedKoo Biosciences, Inc.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.
MedKoo Biosciences, Inc.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.
[CoA] [HNMR] [HPLC] [MS] MedKoo Biosciences, Inc.
[HPLC] [HNMR] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Others
Target Androgen Receptor
Research Area Cancer
Indications Hormone refractory prostate cancer Hormone dependent prostate cancer

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
ARN-509 Aragon Pharmaceuticals Inc Hormone refractory prostate cancer 2013/10/31 2016/12/31 Phase 3 Clinical
ARN-509 Aragon Pharmaceuticals Inc Hormone dependent prostate cancer 2013/2/28 2018/2/28 Phase 2 Clinical
ARN-509 Aragon Pharmaceuticals Inc Hormone refractory prostate cancer 2010/7/31 2013/6/30 Phase 2 Clinical
ARN-509 Aragon Pharmaceuticals Inc 2013/3/31 2013/6/30 Phase 1 Clinical
ARN-509 Aragon Pharmaceuticals Inc; Johnson & Johnson Hormone refractory prostate cancer 2013/2/28 2014/2/01 Phase 1 Clinical
ARN-509 - Phase 3

Chemical Information

M.Wt Formula CAS No. Synonyms
477.43 C21H15F4N5O2S 956104-40-8 ARN 509; ARN509; 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide

Structure Information of ARN-509

Smiles O=C(NC)C1=CC=C(N(C(N(C2=CC(C(F)(F)F)=C(C#N)N=C2)C3=O)=S)C43CCC4)C=C1F
InChI InChI=1S/C21H15F4N5O2S/c1-27-17(31)13-4-3-11(8-15(13)22)30-19(33)29(18(32)20(30)5-2-6-20)12-7-14(21(23,24)25)16(9-26)28-10-12/h3-4,7-8,10H,2,5-6H2,1H3,(H,27,31)

Related Products

Other Form Products of ARN-509

Name CAS Formula Suppliers

Recommended Products in Same Target

Name CAS Formula Suppliers
Lupeol 545-47-1 C30H50O 8
Oxandrolone 53-39-4 C19H30O3 7
Testosterone (undecanoate) 5949-44-0 C30H48O3 9
Spironolactone 52-01-7 C24H32O4S 15
LGD-4033 1165910-22-4 C14H12F6N2O 6
Adrenosterone 382-45-6 C19H24O3 12
Triptophenolide 74285-86-2 C20H24O3 5
Epiandrosterone 481-29-8 C19H30O2 20
3,3'-Diindolylmethane 1968-05-4 C17H14N2 12
Boldenone Undecylenate 13103-34-9 C30H44O3 10
Testosterone 58-22-0 C19H28O2 15
Cyproterone (acetate) 427-51-0 20
GLPG0492 1215085-92-9 C19H14F3N3O3 5
N-desmethyl Enzalutamide 1242137-16-1 C20H14F4N4O2S 5
AZD3514 1240299-33-5 C25H32F3N7O2 11
DHEA 53-43-0 C19H28O2 31
RAD140 1182367-47-0 C20H16ClN5O2 7
Cortexolone 17 alpha-propionate 19608-29-8 C24H34O5 9
BMS-564929 627530-84-1 C14H12ClN3O3 4
MK-0773 606101-58-0 C27H34FN5O2 4

Recommended Products in the Same Indication

Name CAS Formula Suppliers
TAK-700 (R-form) 752243-39-3 C18H17N3O2 1
Olaparib 763113-22-0 C24H23FN4O3 13
KX2-391 897016-82-9 C26H29N3O3 7
Bicalutamide 90357-06-5 C18H14F4N2O4S 20
Enzalutamide 915087-33-1 C21H16F4N4O2S 14
Linsitinib 867160-71-2 C26H23N5O 12
Fenretinide 65646-68-6 C26H33NO2 20
Leuprolide (Acetate) 74381-53-6 C61H88N16O14 15
Retaspimycin 857402-23-4 C31H45N3O8 5
Retaspimycin (Hydrochloride) 857402-63-2 C31H46ClN3O8 4
Bafetinib 859212-16-1 C30H31F3N8O 17
AT13387 912999-49-6 C24H31N3O3 13
Tasquinimod 254964-60-8 C20H17F3N2O4 9
Orteronel 566939-85-3 C18H17N3O2 5
Orteronel (racemate) 426219-18-3 C18H17N3O2 4
TAK-700 (salt) 426219-53-6 C28H28N4O7 2
TOK-001 851983-85-2 C26H32N2O 9
Cabozantinib 849217-68-1 C28H24FN3O5 18
Odanacatib 603139-19-1 C25H27F4N3O3S 12
Zibotentan 186497-07-4 C19H16N6O4S 8

Chemical and Physical Properties

Appearance:White to off-white solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

Tags: buy ARN-509 | ARN-509 IC50 | ARN-509 price | ARN-509 cost | ARN-509 solubility | ARN-509 purchase | ARN-509 manufacturer | ARN-509 research buy | ARN-509 order | ARN-509 MSDS | ARN-509 chemical structure | ARN-509 Storage condition | ARN-509 molecular weight | ARN-509 mw | ARN-509 datasheet | ARN-509 supplier | ARN-509 cell line | ARN-509 NMR | ARN-509 MS | ARN-509 IR | ARN-509 solubility | ARN-509 Safe information | ARN-509 Qc and Spectral Information | ARN-509 Clinical Information | ARN-509 Clinical Trial | ARN-509 Route of Synthesis | ARN-509 storage condition | ARN-509 diseases and conditions | ARN-509 flash point | ARN-509 boiling point | ARN-509 melting point | ARN-509 storage condition | ARN-509 brand