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ARN-509

(CAS: 956104-40-8)

Suppliers of ARN-509

Company Name Email Tel Country
AbMole BioScience [email protected] 1-800-660-8580 USA

Fax: Purity: Brand:

Price and Availability: USD150/10mg (In stock)

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: Brand:

Price and Availability: USD108/5mg (In stock)

BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

Fax: 408-493-1801Purity: Brand:

Price and Availability: USD115/5mg ()

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: >98% Brand:

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

Fax: (734) 971-3640Purity: Brand:

Price and Availability: USD35/1mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: >98% Brand:

Price and Availability: USD70/5mg (In stock) USD120/10mg (In stock) USD350/50mg (In stock) USD550/100mg (In stock)
Quality Control & MSDS Files: HNMR LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: >98% Brand:

Price and Availability: USD150/10mg ()
Quality Control & MSDS Files: CoA HNMR HPLC MS MSDS

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: >98% Brand:

Price and Availability: USD210/5mg (In stock) USD270/10mg (In stock) USD400/10mM/1mLIn DMSO (In stock) USD504/10mM(in 1mL DMSO) (in 1mL DMSO) USD970/50mg (In stock) USD1270/100mg (In stock)
Quality Control & MSDS Files: HPLC HNMR HPLC HNMR HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: >98% Brand:

Price and Availability: USD80/5mg (In stock) USD140/10mg (In stock) USD350/50mg (In stock) USD550/100mg (In stock)

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD124/10mg () USD339/50mg ()

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Background Information of ARN-509

ARN-509 is a selective and competitive androgen receptor inhibitor with IC50 of 16 nM, useful for prostate cancer treatment. IC50 value: 16 nM Target: androgen receptor ARN-509 is an androgen receptor antagonist with potential antineoplastic activity.

Solubility of ARN-509

Solubility Sources
DMSO 15 mg/mL Ethanol 5 mg/mL MedChemexpress Co., Ltd.
Soluble in DMSO, not in water MedKoo Biosciences, Inc.
(25°C) * In vitro DMSO 18 mg/mL (37.7 mM); Ethanol5 mg/mL (10.47 mM); Water<1 mg/mL (<1 mM); In vivo 0.5% CMC, pH4.014 mg/mL Selleck Chemicals LLC

Storage Condition of ARN-509

Storage Condition Sources
Storage condition:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). Stock solution storage:0 - 4 C for short term (days to weeks), or -20 C for long term (months). Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. MedKoo Biosciences, Inc.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.
MedKoo Biosciences, Inc.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.
[CoA] [HNMR] [HPLC] [MS] MedKoo Biosciences, Inc.
[HPLC] [HNMR] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Others
Target Androgen Receptor
Research Area Cancer
Indications Hormone refractory prostate cancer Hormone dependent prostate cancer

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
ARN-509 Aragon Pharmaceuticals Inc Hormone refractory prostate cancer 2013/10/31 2016/12/31 Phase 3 Clinical
ARN-509 Aragon Pharmaceuticals Inc Hormone dependent prostate cancer 2013/2/28 2018/2/28 Phase 2 Clinical
ARN-509 Aragon Pharmaceuticals Inc Hormone refractory prostate cancer 2010/7/31 2013/6/30 Phase 2 Clinical
ARN-509 Aragon Pharmaceuticals Inc 2013/3/31 2013/6/30 Phase 1 Clinical
ARN-509 Aragon Pharmaceuticals Inc; Johnson & Johnson Hormone refractory prostate cancer 2013/2/28 2014/2/01 Phase 1 Clinical
ARN-509 - Phase 3

Chemical Information

M.Wt Formula CAS No. Synonyms
477.43 C21H15F4N5O2S 956104-40-8 ARN 509; ARN509; 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide

Structure Information of ARN-509

Smiles O=C(NC)C1=CC=C(N(C(N(C2=CC(C(F)(F)F)=C(C#N)N=C2)C3=O)=S)C43CCC4)C=C1F
InChI InChI=1S/C21H15F4N5O2S/c1-27-17(31)13-4-3-11(8-15(13)22)30-19(33)29(18(32)20(30)5-2-6-20)12-7-14(21(23,24)25)16(9-26)28-10-12/h3-4,7-8,10H,2,5-6H2,1H3,(H,27,31)

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Chemical and Physical Properties

Appearance:White to off-white solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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