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Briciclib

(CAS: 865783-99-9)

Suppliers of Briciclib

Company Name Email Tel Country
Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

Fax: +1 (847) 367-3681Purity: Brand:

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC sales[email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD180/1mg () USD420/5mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

Fax: (734) 971-3640Purity: Brand:

DC Chemicals [email protected]; [email protected] +86-21-58447131 China

Fax: +86-21-61642470Purity: Brand:

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD180/1mg () USD420/5mg ()
Quality Control & MSDS Files: HNMR LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: Brand:

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD180/1mg () USD420/5mg ()

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Background Information of Briciclib

Briciclib is a water soluble derivative of ON 013100, and has the potential in targeting eIF4E for solid cancers.

Solubility of Briciclib

Solubility Sources
DMSO: > 31 mg/mL CHEMSCENE, LLC
DMSO: > 31 mg/mL MedChemexpress Co., Ltd.

Storage Condition of Briciclib

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Cell Cycle/DNA Damage
Target CDK
Research Area Cancer
Indications Neoplasms Advanced Solid Tumor Lymphoma Acute Lymphocytic Leukemia

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Briciclib Onconova Therapeutics, Inc Neoplasms Advanced Solid Tumor 2014/6/18 2015/12/01 Phase 1 Clinical
Briciclib Onconova Therapeutics, Inc. Lymphoma Acute Lymphocytic Leukemia 2010/1/11 2015/12/01 Phase 1 Clinical
Briciclib - Phase 1

Chemical Information

M.Wt Formula CAS No. Synonyms
474.4187 C19H23O10PS 865783-99-9 ON 014185

Structure Information of Briciclib

Smiles O=S(CC1=CC(OP(O)(O)=O)=C(OC)C=C1)(/C=C/C2=C(OC)C=C(OC)C=C2OC)=O
InChI InChI=1S/C19H23O10PS/c1-25-14-10-17(27-3)15(18(11-14)28-4)7-8-31(23,24)12-13-5-6-16(26-2)19(9-13)29-30(20,21)22/h5-11H,12H2,1-4H3,(H2,20,21,22)/b8-7+

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:Soluble in DMSO, not in water
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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