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Ezetimibe

(CAS: 163222-33-1)

Suppliers of Ezetimibe

Company Name Email Tel Country
Abblis Chemicals LLC [email protected] Toll Free: 1-877-799-4928 (US and Canada only) Tel:+1-877-799-4928 USA

Fax: Fax:+1-713-664-0347Purity: Brand:

Price and Availability: USD50/25mg (In Stock)

Anhui Lianchuang Pharmaceutical Chemistry Co., Ltd. [email protected],[email protected] +86 (551) 6859-6228 / 6877-9238 China

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Arromax Pharmatech Co., Ltd. [email protected] +86 (512) 6295-4815 China

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BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

Fax: 408-493-1801Purity: Brand:

Price and Availability: USD75/25mg ()

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD60/10mg () USD106/50mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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Price and Availability: USD59/25mg ()

Clearsynth Labs Limited [email protected] Worldwide Helpline No. +1-415-685-4395; US & Canada (Toll-free) : +1-800-650-8239; Europe : +44-20-3286-0885; India : +91-22-26355700 India

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Price and Availability: USD100/25mg ()

Hangzhou Hysen Pharma Co., Ltd. [email protected] +86 (571) 8829-8691 China

Fax: +86 (571) 2891-8299Purity: Brand:

J&K Scientific Ltd. [email protected];[email protected] 400-666-7788 / +86 10 8284 8833 China

Fax: +86 10 8284 9933Purity: Brand:

Price and Availability: RMB818/10mg ()

Janlon Biopharma Co., Ltd. [email protected] +86 (512) 6790-9115 China

Fax: +86 (512) 6790-9117Purity: Brand:

Manus Aktteva [email protected] +91 (79) 6512-3395 India

Fax: +91 (79) 2646-3395Purity: Brand:

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD60/10mg () USD106/50mg ()
Quality Control & MSDS Files: HNMR LCMS MSDS

Santa Cruz Biotechnology, Inc. [email protected] Toll Free: 800-457-3801 Phone: 214-902-3900 USA

Fax: 214-358-6070Purity: Brand:

Price and Availability: USD86/25mg ()

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: >98% Brand:

Price and Availability: USD97/50mg (In stock) USD130/10mM/1mLIn DMSO (In stock)
Quality Control & MSDS Files: HPLC HNMR HPLC HPLC HNMR HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD60/10mg () USD106/50mg ()

Suzhou Lanxite Biotechnology Co., Ltd. [email protected],[email protected] +86 (512) 8518-0611 China

Fax: +86 (512) 8917-1181Purity: Brand:

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .97 Brand: TargetMol

Price and Availability: USD20/2mg () USD41/10mg () USD78/50mg () USD122/200mg ()

Tianjin Collabrate Chemical Industry. Co., Ltd. [email protected] +86 (22) 6330-1939 China

Fax: +86 (22) 6315-2797Purity: Brand:

Xuchang Chenhe Bio-pharmaceutical Tech. Co., Ltd. [email protected],[email protected] +86 (374) 579-3128 / +86 15836530076 China

Fax: +86 (374) 579-3128Purity: Brand:

Yitai Pharmatech Co., Ltd. [email protected] +86 (10) 6780-6114 / +86 13811836936 China

Fax: +86 (10) 6780-6115Purity: Brand:

Zhejiang Esun Chemical Co., Ltd. [email protected] +86 (571) 5628-6531 China

Fax: +86 (571) 5628-7608Purity: Brand:

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Background Information of Ezetimibe

Ezetimibe, a cholesterol-absorption inhibitor, reduces levels of low-density lipoprotein (LDL) cholesterol when added to statin treatment.

Solubility of Ezetimibe

Solubility Sources
DMSO MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 82 mg/mL (200.29 mM); Ethanol82 mg/mL (200.29 mM); Water<1 mg/mL (<1 mM); In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O10mg/mL Selleck Chemicals LLC

Storage Condition of Ezetimibe

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.
[HPLC] [HNMR] Selleck Chemicals LLC

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Ezetimibe Hospital Italiano de Buenos Aires Lipid metabolism disorder 2011/10/31 2013/5/31 Phase 4 Clinical
Ezetimibe Seoul National University Non-insulin dependent diabetes 2010/9/30 2011/8/31 Phase 4 Clinical
Ezetimibe Shanghai Jiao Tong University Coronary artery disease 2010/1/31 2012/12/31 Phase 4 Clinical
Ezetimibe Yokohama City University Medical Center Coronary artery disease 2010/10/31 2015/10/31 Phase 4 Clinical
Ezetimibe Kumamoto University Coronary artery disease 2010/1/31 2013/12/31 Phase 4 Clinical
Ezetimibe - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
409.43 C24H21F2NO3 163222-33-1 1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxy-propyl]-4-(4-hydroxyphenyl)-azetidin-2-one; (3R,4S)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one

Structure Information of Ezetimibe

Smiles O=C1N(C2=CC=C(F)C=C2)[[email protected]](C3=CC=C(O)C=C3)[[email protected]]1CC[[email protected]](O)C4=CC=C(F)C=C4
InChI InChI=1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2/t21-,22+,23-/m1/s1

Related Products

Other Form Products of Ezetimibe

Name CAS Formula Suppliers
Ezetimibe D4 1093659-90-5 C24H17D4F2NO3 4

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Curcumin 458-37-7 C21H20O6 16
Dimethyl fumarate 624-49-7 C6H8O4 17
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Bardoxolone (methyl) 218600-53-4 C32H43NO4 8
Hinokitiol 499-44-5 C10H12O2 7
NK-252 1414963-82-8 C13H11N5O3 4
Ezetimibe D4 1093659-90-5 C24H17D4F2NO3 4
Danshensu 76822-21-4 C9H10O5 5
ML385 846557-71-9 C31H29N3O2S 3
Cpd16 C24H22N2O6S2 0
Cpd16-AA C28H26N2O10S2 0
TBE-31 C21H18N2O2 0
AEM1 C20H14FN3O2S 0
Lyngbyabellin A C29H40Cl2N4O7S2 0
Grassypeptolide A C56H79N9O10S2 0

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Name CAS Formula Suppliers
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Teneligliptin 760937-92-6 C22H30N6OS 8
Empagliflozin 864070-44-0 C23H27ClO7 18
MK 0893 870823-12-4 C32H27Cl2N3O4 4
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Manidipine (dihydrochloride) 89226-75-5 C35H40Cl2N4O6 9
Teneligliptin (hydrobromide) 906093-29-6 C44H65Br5N12O2S2 8
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Linagliptin 668270-12-0 C25H28N8O2 15
Choline Fenofibrate 856676-23-8 C22H28ClNO5 9
Bardoxolone (methyl) 218600-53-4 C32H43NO4 8
Saxagliptin 361442-04-8 C18H25N3O2 17
Alogliptin 850649-61-5 C18H21N5O2 11
Alogliptin (Benzoate) 850649-62-6 C25H27N5O4 13
Aleglitazar (racemate) 475479-24-4 C24H23NO5S 6
Laropiprant 571170-77-9 C21H19ClFNO4S 8
Imeglimin (hydrochloride) 775351-61-6 C6H14ClN5 6

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:164-166°C
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

Reference

[1].Xiaobo Lin, Susan B. Racette, Michael Lefevre, et al. Combined Effects of Ezetimibe and Phytosterols on Cholesterol Metabolism: A Randomized, Controlled Feeding Study in Humans. Circulation. 2011; 124(5): 596-601.
Background Both ezetimibe and phytosterols inhibit cholesterol absorption. We tested the hypothesis that ezetimibe combined with phytosterols is more effective than ezetimibe alone in altering cholesterol metabolism. Methods and Results Twenty-one mildly hypercholesterolemic subjects completed a randomized, double-blind, placebo-controlled, triple crossover study. Each subject received a phytosterol-controlled diet plus (1) ezetimibe placebo + phytosterol placebo, (2) 10 mg ezetimibe/day + phytosterol placebo, and (3) 10 mg ezetimibe/day + 2.5 g phytosterols/day, for 3 weeks each. All meals were prepared in a metabolic kitchen. Primary outcomes were intestinal cholesterol absorption, fecal cholesterol excretion, and LDL cholesterol levels. The combined treatment resulted in significantly lower intestinal cholesterol absorption (598 mg/day, 95% CI 368 to 828) relative to control (2161 mg/day, 1112 to 3209) and ezetimibe alone (1054 mg/day, 546 to 1561, both P < 0.0001). Fecal cholesterol excretion was significantly greater (P < 0.0001) with combined treatment (962 mg/day, 757 to 1168) relative to control (505 mg/day, 386 to 625) and ezetimibe alone (794 mg/day, 615 to 973). Plasma LDL cholesterol values during control, ezetimibe alone, and ezetimibe + phytosterols averaged 129 (95% CI: 116 to 142), 108 (97 to 119), and 101 (90 to 112) mg/dL (P < 0.0001 relative to control). Conclusion The addition of phytosterols to ezetimibe significantly enhanced the effects of ezetimibe on whole-body cholesterol metabolism and plasma LDL cholesterol. The large cumulative action of combined dietary and pharmacologic treatment on cholesterol metabolism emphasizes the potential importance of dietary phytosterols as adjunctive therapy for the treatment of hypercholesterolemia.

[2].Anne B. Rosseb?, Terje R. Pedersen, Kurt Boman, et al. Intensive Lipid Lowering with Simvastatin and Ezetimibe in Aortic Stenosis. N Engl J Med 2008; 359:1343-1356.

[3].John J.P. Kastelein, Fatima Akdim, Erik S.G. Stroes, et al. Simvastatin with or without Ezetimibe in Familial Hypercholesterolemia. N Engl J Med ,2008; 358:1431-1443.

[4].Christie M. Ballantyne, John Houri, Alberto Notarbartolo, et al. Effect of Ezetimibe Coadministered With Atorvastatin in 628 Patients With Primary Hypercholesterolemia. Clinical Investigation and Reports Circulation. 2003; 107: 2409-2415.

[5].Claude Gagne?, Harold E. Bays, Stuart R. Weiss, et al. Efficacy and Safety of Ezetimibe Added to Ongoing Statin Therapy for Treatment of Patients With Primary Hypercholesterolemia. Am J Cardiol 2002;90:1084-1091.

[6].Ezetimibe

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