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(24R)-MC 976

(CAS: 112828-09-8)

Suppliers of (24R)-MC 976

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AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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Price and Availability: USD400/0mg () USD400/0mg ()

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Price and Availability: USD925/1mg ()

Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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BOC Sciences [email protected] 1-631-504-6093

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD1110/1mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Price and Availability: USD1110/1mg ()

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Background Information of (24R)-MC 976

(24R)-MC 976 is a Vitamin D3 derivative.

Solubility of (24R)-MC 976

Solubility Sources
DMSO MedChemexpress Co., Ltd.

Storage Condition of (24R)-MC 976

Storage Condition Sources

MSDS Information

MSDS Sources

Quality Control and Spectral Data

QC Reports Sources

Mechanism and Indications

Signaling Pathways Others
Target VD/VDR
Research Area Metabolic Disease
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
(24R)-MC 976 - Not Found
(24R)-MC 976 - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
414.62 C27H42O3 112828-09-8 (24R)-MC-976;(24R)-MC976; (1R,3S,Z)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5R)-5-cyclopropyl-5-hydroxypentan-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol

Structure Information of (24R)-MC 976

Smiles C=C1[[email protected]@H](O)C[[email protected]](O)C/C1=C/C=C2[[email protected]@](CC[[email protected]@H]3[[email protected]@H](CC[[email protected]@H](O)C4CC4)C)([H])[[email protected]]3(C)CCC/2
InChI InChI=1S/C27H42O3/c1-17(6-13-25(29)20-8-9-20)23-11-12-24-19(5-4-14-27(23,24)3)7-10-21-15-22(28)16-26(30)18(21)2/h7,10,17,20,22-26,28-30H,2,4-6,8-9,11-16H2,1,3H3/b19-7+,21-10-/t17-,22-,23-,24+,25-,26+,27-/m1/s1

Related Products

Other Form Products of (24R)-MC 976

Name CAS Formula Suppliers
(24S)-MC 976 112849-14-6 C27H42O3 9
MC 976 129831-99-8 C27H42O3 10

Recommended Products in Same Target

Name CAS Formula Suppliers
25,26-Dihydroxyvitamin D3 29261-12-9 C27H44O3 6
(24S)-24,25-Dihydroxyvitamin D3 55700-58-8 C27H44O3 8
Calcitriol Impurities D 103656-40-2 C28H46O3 5
Calcifediol (monohydrate) 63283-36-3 C27H44O2 16
Cholecalciferol 67-97-0 C27H44O 15
(24S)-MC 976 112849-14-6 C27H42O3 9
(1S,4R,E)-4-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-ol C39H68O3Si2 5
VD3-D6 118584-54-6 C27H38D6O 5
VD2-D3 1217448-46-8 C28H41D3O 9
25-Hydroxy VD2-D6 1262843-46-8 C28H38D6O2 9
1alpha, 25-Dihydroxy VD2-D6 216244-04-1 C28H38D6O3 9
Calcipotriol (monohydrate) 147657-22-5 C27H42O4 13
Cholecalciferol 67-97-0 C27H44O 12
Calcitriol Impurities A 73837-24-8 C27H44O3 7
(1R,3S,E)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol 910133-70-9 C27H40O3 4
Paricalcitol 131918-61-1 C27H44O3 20
MC 976 129831-99-8 C27H42O3 10
24R-Calcipotriol 112827-99-3 C27H40O3 7
MC 1046 126860-83-1 C27H38O3 8
3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 163018-26-6 C30H51NO2 9

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Chemical and Physical Properties

Appearance:Light yellow to yellow solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

Reference

[1].Strugnell, Stephen; Calverley, Martin J.; Jones, Glenville. Metabolism of a cyclopropane ring-containing analog of 1α-hydroxyvitamin D3 in a hepatocyte cell model. Identification of 24-oxidized metabolites. Biochemical Pharmacology (1990), 40(2), 333-41.
MC 969 is an analog of the calcemic drug 1α-hydroxyvitamin D3 (1α-OH-D3) in which carbons 25, 26, and 27 in the side chain are incorporated into a cyclopropane ring. Metabolites of MC 969 were generated in an in vitro human hepatocyte cell model, Hep 3B. The identity of the metabolites was established by comigration on HPLC with authentic standards, and by mass spectrometry of native and chemically modified metabolites Unequivocal identification of the 24-keto- and the two epimeric 24-alcohol metabolites is provided. No 25-hydroxylated metabolites were detected. In competition studies, MC 969 was able to inhibit 25-hydroxylation of tritiated vitamin D3 more effectively than 1α-OH-D3 itself, indicating that the vitamin D3-25-hydroxylase may be responsible for generation of one or more of the metabolites observed.

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