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Etoposide

(CAS: 33419-42-0)

Suppliers of Etoposide

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AOBIOUS INC [email protected] (508) 306-0937 USA

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AbMole BioScience [email protected] 1-800-660-8580 USA

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Adipogen Corporation [email protected] (858) 457-8383 USA

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Aladdin [email protected] 400 620 6333 China

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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BOC Sciences acc[email protected] 1-631-504-6093

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BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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Jiangsu Zhongdan Group Co., Ltd. [email protected] +86 (523) 8798-3888 China

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LC Laboratoies [email protected] +1-781-937-0777 +1-800-937-3720 in US and Canada only USA

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Lianyungang Guike Pharmaceutical Co., ltd. [email protected] +86 (518) 8607-0808 / 8607-0855 China

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Lianyungang Jinkang Pharmaceutical Technology Co., Ltd. [email protected],[email protected] +86 (518) 8544-5517 China

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD60/100mg () USD84/200mg ()
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MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Price and Availability: USD70/100mg (In stock) USD91/10mM/1mLIn DMSO (In stock) USD280/500mg (In stock)
Quality Control & MSDS Files: HPLC HNMR

Shandong Kingnod Pharmaceuticals Co., Ltd. [email protected] +86 (533) 815-5527 / +86 15053385713 China

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Shanghai Jinhe Bio-Technology Co., Ltd. [email protected],[email protected] +86 (21) 5981-0660 China

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Shanghai Orient Chemical Co., Ltd. [email protected],[email protected] +86 (21) 5996-9669 China

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Shanghai SPE Chemicals Co., Ltd. [email protected],[email protected] +86 (21) 5138-6314 China

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Suzhou Unite Pharmtech Co., Ltd. [email protected],[email protected] +86 (512) 8766-6020 / +86 13222993784 China

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Taizhou Bolon Pharmachem Co., Ltd. [email protected] +86 (576) 8870-2852 China

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Target Molecule Corp. [email protected] (857) 239-0968 USA

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Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

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Yancheng Hejia Chemical Co., Ltd. [email protected] +86 (515) 8788-3188 China

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Background Information of Etoposide

Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. Target: Topoisomerase Approved: 1983 Etoposide inhibits the growth of murine angiosarcoma cell line (ISOS-1) in a 5 days-period with IC50 of 0.25 μg/mL.

Solubility of Etoposide

Solubility Sources
Soluble in DMSO at 100 mg/mL; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be 20-50 μM; buffers, serum or other additives may increase or decrease the aqueous solubility. LC Laboratoies
DMSO 100 mg/mL;Water <1 mg/mL MedChemexpress Co., Ltd.
DMSO 100 mg/mL (169 mM) ; Water <1 mg/mL (<1 mM) ; Ethanol <1 mg/mL (<1 mM) Selleck Chemicals LLC

Storage Condition of Etoposide

Storage Condition Sources
Store at or below -20 oC. LC Laboratoies

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [HNMR] MedChemexpress Co., Ltd.
[HPLC] [HNMR] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Cell Cycle/DNA Damage Autophagy
Target Topoisomerase Autophagy
Research Area Cancer
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Etoposide - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
588.56 C29H32O13 33419-42-0 VP-16;VP-16-213; (5R,5aR,8aR,9S)-9-(((2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methylhexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy)-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one

Structure Information of Etoposide

Smiles O=C1OC[[email protected]]2([H])[[email protected]](O[[email protected]]3[[email protected]@H]([[email protected]]([[email protected]@H]4O[[email protected]](C)OC[[email protected]]4O3)O)O)C5=C(C=C6OCOC6=C5)[[email protected]@H](C7=CC(OC)=C(O)C(OC)=C7)[[email protected]]21[H]
InChI InChI=1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1

Related Products

Other Form Products of Etoposide

Name CAS Formula Suppliers
Etoposide Phosphate 117091-64-2 C29H33O16P 8

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Safety Data of Etoposide

Hazard Symbols:T,Xi Risk Statements:45-22-36/37/38 Safety Statements:53-45-36/37-26
Transport Information: HS Code: RTECS:KC0190000
WGK Germany:3

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:236-251 °C(lit.)
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,100 mg/mL(169.9 mM);In vitro:Water,Insoluble;In vitro:Ethanol,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):5% DMSO+30% PEG 300+H2OFor best results, use promptly afte
Density: Merck:3886
BRN: Refractive Index: -110.5 ° (C=0.6, CHCl3)
Vapour: EINECS:251-509-1
Optical Rotation: alpha:

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