Palbociclib (hydrochloride) (CAS: 827022-32-2)
Suppliers of Palbociclib (hydrochloride)
Background Information of Palbociclib (hydrochloride)
Palbociclib Hcl(PD-0332991) is a highly specific inhibitor of Cdk4 (IC50=11 nM) and Cdk6 (IC50=16 nM), having no activity against a panel of 36 additional protein kinases.
IC50 value: 11 nM/16 nM (Cdk4/Cdk6) 
in vitro: ATP competitive inhibitor of Cdk4.
Solubility of Palbociclib (hydrochloride)
Storage Condition of Palbociclib (hydrochloride)
MedChemexpress Co., Ltd.
|Storage condition:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). Stock solution storage:0 - 4 C for short term (days to weeks), or -20 C for long term (months). Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
MedKoo Biosciences, Inc.
Quality Control and Spectral Data
Mechanism and Indications
||PD-0332991 hydrochloride;PD0332991 hydrochloride;PD 0332991 hydrochloride; 6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride
Structure Information of Palbociclib (hydrochloride)
Other Form Products of Palbociclib (hydrochloride)
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Safety Data of Palbociclib (hydrochloride)
Chemical and Physical Properties
|Appearance:Light yellow to yellow Solid
.Fry DW, et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther, 2004, 3(11), 1427-1438.
.Finn RS, et al. PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro. Breast Cancer Res, 2009, 11(5), R77.
.Katsumi Y, et al. Sensitivity of malignant rhabdoid tumor cell lines to PD 0332991 is inversely correlated with p16 expression. Biochem Biophys Res Commun, 2011, 413(1), 62-68.