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Palbociclib (hydrochloride)

(CAS: 827022-32-2)

Suppliers of Palbociclib (hydrochloride)

Company Name Email Tel Country
Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: Brand:

Price and Availability: USD70/5mg (In Stock)

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD60/5mg () USD84/10mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

Fax: (734) 971-3640Purity: Brand:

Price and Availability: USD25/1mg ()

DC Chemicals [email protected]; [email protected] +86-21-58447131 China

Fax: +86-21-61642470Purity: Brand:

Price and Availability: USD200/100mg (In Stock)

EMD Millipore USA

Fax: Purity: Brand:

Price and Availability: USD99/5mg ()

LC Laboratoies [email protected] +1-781-937-0777 +1-800-937-3720 in US and Canada only USA

Fax: +1-781-938-5420Purity: > 99% Brand:

Price and Availability: USD47/10mg (In stock) USD64/25mg (In stock) USD87/50mg (In stock) USD139/100mg (In stock) USD235/200mg (In stock) USD484/500mg (In stock) USD792/1g (In stock) USD1384/2g (In stock)

Lancrix Chemicals. [email protected] 86 21 50817262 China

Fax: 86 21 57712035Purity: Brand:

Price and Availability: USD198/50mg () USD558/200mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD60/5mg () USD84/10mg ()
Quality Control & MSDS Files: HNMR LCMS NP-HPLC MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: >98% Brand:

Price and Availability: USD120/100mg ()
Quality Control & MSDS Files: CoA HNMR HPLC LCMS MS MSDS

Santa Cruz Biotechnology, Inc. [email protected] Toll Free: 800-457-3801 Phone: 214-902-3900 USA

Fax: 214-358-6070Purity: Brand:

Price and Availability: USD120/5mg ()

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: >98% Brand:

Price and Availability: USD110/5mg (In stock) USD170/10mg (In stock) USD220/10mM/1mLIn DMSO (In stock) USD570/50mg (In stock)
Quality Control & MSDS Files: HPLC HNMR

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD60/5mg () USD84/10mg ()

Shanghai Sun-shine Chemical Technology Co., Ltd. [email protected],[email protected] +86 (27) 5925-3327 China

Fax: +86 (27) 5925-3326Purity: Brand:

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD68/5mg () USD89/10mg () USD158/25mg () USD290/50mg ()

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Background Information of Palbociclib (hydrochloride)

Palbociclib Hcl(PD-0332991) is a highly specific inhibitor of Cdk4 (IC50=11 nM) and Cdk6 (IC50=16 nM), having no activity against a panel of 36 additional protein kinases. IC50 value: 11 nM/16 nM (Cdk4/Cdk6) [1] Target: Cdk4/Cdk6 in vitro: ATP competitive inhibitor of Cdk4.

Solubility of Palbociclib (hydrochloride)

Solubility Sources
H2O: 30 mg/mL, DMSO: 3 mg/mL (warmed) CHEMSCENE, LLC
H2O: 30 mg/mL, DMSO: 3 mg/mL (warmed) MedChemexpress Co., Ltd.
Soluble in DMSO, not in water MedKoo Biosciences, Inc.
DMSO 3 mg/mL (6 mM) ; Water 30 mg/mL (61 mM) ; Ethanol <1 mg/mL (<1 mM) Selleck Chemicals LLC

Storage Condition of Palbociclib (hydrochloride)

Storage Condition Sources
4°C MedChemexpress Co., Ltd.
Storage condition:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). Stock solution storage:0 - 4 C for short term (days to weeks), or -20 C for long term (months). Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. MedKoo Biosciences, Inc.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.
MedKoo Biosciences, Inc.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] [NP-HPLC] MedChemexpress Co., Ltd.
[CoA] [HNMR] [HPLC] [LCMS] [MS] MedKoo Biosciences, Inc.
[HPLC] [HNMR] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Cell Cycle/DNA Damage
Target CDK
Research Area Cancer
Indications Acute leukemia

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Palbociclib (hydrochloride) Sidney Kimmel Comprehensive Cancer Center Acute leukemia 2012/9/30 2013/4/30 Phase 1 Clinical
Palbociclib (hydrochloride) - Phase 3 Clinical
Palbociclib (hydrochloride) - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
483.99 C24H30ClN7O2 827022-32-2 PD-0332991 hydrochloride;PD0332991 hydrochloride;PD 0332991 hydrochloride; 6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride

Structure Information of Palbociclib (hydrochloride)

Smiles O=C1C(C(C)=O)=C(C)C2=CN=C(NC3=NC=C(N4CCNCC4)C=C3)N=C2N1C5CCCC5.Cl
InChI InChI=1S/C24H29N7O2.ClH/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32;/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29);1H

Related Products

Other Form Products of Palbociclib (hydrochloride)

Name CAS Formula Suppliers
Palbociclib (isethionate) 827022-33-3 C26H35N7O6S 22
Palbociclib 571190-30-2 C24H29N7O2 25

Recommended Products in Same Target

Name CAS Formula Suppliers
LY2857785 1619903-54-6 C26H36N6O 12
THZ2 1604810-84-5 C31H28ClN7O2 10
Palbociclib (isethionate) 827022-33-3 C26H35N7O6S 22
CDK9-IN-6 1391855-95-0 C27H37ClN6O2 5
ML167 1285702-20-6 C19H17N3O3 15
AMG 925 1401033-86-0 C26H29N7O2 15
LDC000067 1073485-20-7 C18H18N4O3S 11
LEE011 (succinate hydrate) 1374639-79-8 C27H38N8O6X 8
LEE011 (succinate) 1374639-75-4 C27H36N8O5 9
LEE011 (hydrochloride) 1211443-80-9 C23H31ClN8O 8
LEE011 1211441-98-3 C23H30N8O 21
WHI-P180 (hydrochloride) 153437-55-9 C16H16ClN3O3 6
Wogonin 632-85-9 C16H12O5 28
1-NM-PP1 221244-14-0 C20H21N5 17
WHI-P180 211555-08-7 C16H15N3O3 13
THZ1 1604810-83-4 C31H28ClN7O2 18
Senexin A 1366002-50-7 C17H14N4 8
CDK4-IN-1 1256963-02-6 C22H29ClN8 9
Purvalanol B 212844-54-7 C20H25ClN6O3 22
NU6102 444722-95-6 C18H22N6O3S 8

Recommended Products in the Same Indication

Name CAS Formula Suppliers
AT9283 896466-04-9 C19H23N7O2 21
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AVN-944 297730-17-7 C25H27N5O5 13
Lurbinectedin 497871-47-3 C41H44N4O10S 5

Chemical and Physical Properties

Appearance:Light yellow to yellow Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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