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Tirapazamine

(CAS: 27314-97-2)

Suppliers of Tirapazamine

Company Name Email Tel Country
AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

Fax: 866-333-9607 (US & Canada Toll Free) +1-323-606-8156 (Outside of US & Canada)Purity: Brand:

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: Brand:

Price and Availability: USD60/50mg (In stock)

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: 0.98 Brand: BOC Sciences

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 0.98 Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD72/50mg () USD132/100mg ()

Carbosynth Limited [email protected] +44 (1635) 578-444

Fax: +44 (1635) 579-444Purity: Brand:

Price and Availability: USD140/50mg ()

China Jintai Biocompound Company [email protected] +86 (755) 8526-9922 China

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Clearsynth Labs Limited [email protected] Worldwide Helpline No. +1-415-685-4395; US & Canada (Toll-free) : +1-800-650-8239; Europe : +44-20-3286-0885; India : +91-22-26355700 India

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Price and Availability: USD100/25mg ()

Linxiang Huanyu Pharmaceutical Co., Ltd. [email protected] +86 (730) 376-8881 / 372-1068 China

Fax: +86 (730) 373-0599Purity: Brand:

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD72/50mg () USD132/100mg ()
Quality Control & MSDS Files: HNMR HNMR LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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Santa Cruz Biotechnology, Inc. [email protected] Toll Free: 800-457-3801 Phone: 214-902-3900 USA

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Price and Availability: USD278/100mg ()

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD72/50mg () USD132/100mg ()

Sigma-Aldrich, Inc. [email protected] +86 (21) 6141-5566 / 800-819-3336 USA

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Price and Availability: USD54/10mg ()

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Background Information of Tirapazamine

Tirapazamine(SR259075; Win59075; SR4233) is an experimental anticancer drug that is activated to a toxic radical only at very low levels of oxygen; a phenomenon known as tumor hypoxia. IC50 value: Target: in vitro: Tirapazamine could downregulate HIF-1α expression by decreasing HIF-1α protein synthesis.

Solubility of Tirapazamine

Solubility Sources
DMSO MedChemexpress Co., Ltd.

Storage Condition of Tirapazamine

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Tirapazamine Sanofi Head and Neck Neoplasms 2004/10/11 2010/2/01 Phase 3 Clinical
Tirapazamine National Cancer Institute (NCI) Limited Stage Small Cell Lung Cancer 2003/8/06 2012/12/01 Phase 2 Clinical
Tirapazamine National Cancer Institute (NCI) Cervical Adenocarcinoma Cervical Adenosquamous Cell Carcinoma Cervical Squamous Cell Carcinoma Cervical Cancer 2005/12/06 2014/6/01 Phase 3 Clinical
Tirapazamine Teclison Ltd. Hepatocellular Carcinoma 2014/6/10 2015/8/01 Phase 1 Clinical
Tirapazamine Sanofi Lung Cancer 2001/6/06 2010/2/01 Phase 3 Clinical
Tirapazamine - Phase 3

Chemical Information

M.Wt Formula CAS No. Synonyms
178.15 C7H6N4O2 27314-97-2 SR259075;SR4233;Tirazone;Win59075; 3-aminobenzo[e][1,2,4]triazine 1,4-dioxide

Structure Information of Tirapazamine

Smiles NC1=[N+]([O-])C2=CC=CC=C2[N+]([O-])=N1
InChI InChI=1S/C7H6N4O2/c8-7-9-11(13)6-4-2-1-3-5(6)10(7)12/h1-4H,(H2,8,9)

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Safety Data of Tirapazamine

Hazard Symbols:Xi Risk Statements:36/37/38 Safety Statements:26-36
Transport Information: HS Code: RTECS:DM0671500
WGK Germany:

Chemical and Physical Properties

Appearance:Pink to red Solid Melting point:220°C dec.
Boiling point: Flash Point:
Water Solubility: Solubility:DMSO
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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