• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

Afatinib (dimaleate)

(CAS: 850140-73-7)

Suppliers of Afatinib (dimaleate)

Company Name Email Tel Country
Active Biochem [email protected]; [email protected] 1-800-857-0985 (USA Toll Free#) USA

Fax: 1-201-884-1288 (USA Fax#)Purity: Brand:

Price and Availability: USD90/50mg ()

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: Brand:

Price and Availability: USD39/10mg ()

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: > 95% Brand: BOC Sciences

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD60/10mg () USD132/50mg ()

Jinan Chuancheng Pharmaceutical Co., Ltd. [email protected] +86 (531) 8890-2485 China

Fax: +86 (531) 8890-2485Purity: Brand:

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD60/10mg () USD132/50mg ()
Quality Control & MSDS Files: HNMR LCMS HNMR HNMR LCMS LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: Brand:

Price and Availability: USD50/10mg ()

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: Brand:

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD60/10mg () USD132/50mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD98/20mg () USD168/50mg () USD318/100mg ()

Inquiry Online

Salutation: *Country:
*Customer: *Company Name:
*Email: *Request quantity:
Remarks:
 

Notice: Your contact information will be sent to selected suppliers.

* Required Fields.

Background Information of Afatinib (dimaleate)

Afatinib (BIBW2992) irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. IC50 value: 0.5 nM/0.4 nM/10 nM/14 nM (EGFR(wt)/EGFR(L858R)/EGFR(L858R/T790M) /HER2) [1] Target: EGFR;EGFR mutant forms; HER2 in vitro: BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2.

Solubility of Afatinib (dimaleate)

Solubility Sources
DMSO MedChemexpress Co., Ltd.

Storage Condition of Afatinib (dimaleate)

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Afatinib (dimaleate) Boehringer Ingelheim Corp; ICON Clinical Research Metastatic non small cell lung cancer 2012/3/31 2015/1/31 Phase 3 Clinical
Afatinib (dimaleate) Boehringer Ingelheim Corp Metastatic non small cell lung cancer 2013/9/30 2015/12/31 Phase 3 Clinical
Afatinib (dimaleate) Boehringer Ingelheim Corp Metastatic head and neck cancer 2013/5/31 2016/4/30 Phase 3 Clinical
Afatinib (dimaleate) Boehringer Ingelheim Pharmaceuticals Inc Metastatic non small cell lung cancer 2013/7/31 2015/7/31 Phase 3 Clinical
Afatinib (dimaleate) Boehringer Ingelheim Pharmaceuticals Inc Diarrhea 2013/4/30 2015/2/28 Phase 3 Clinical
Afatinib (dimaleate) - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
718.08 C32H33ClFN5O11 850140-73-7 BIBW 2992MA2;BIBW-2992;BIBW2992;BIBW 2992;Afatinib; (S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide dimaleate

Structure Information of Afatinib (dimaleate)

Smiles O=C(NC1=C(C=C2C(C(NC3=CC(Cl)=C(C=C3)F)=NC=N2)=C1)O[[email protected]]4CCOC4)/C=C/CN(C)C.O=C(O)/C=CC(O)=O.O=C(O)/C=CC(O)=O
InChI InChI=1S/C24H25ClFN5O3.2C4H4O4/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15;2*5-3(6)1-2-4(7)8/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29);2*1-2H,(H,5,6)(H,7,8)/b4-3+;2*2-1-/t16-;;/m0../s1

Related Products

Other Form Products of Afatinib (dimaleate)

Name CAS Formula Suppliers
Afatinib (BIBW 2992) 439081-18-2 C24H25ClFN5O3 9
2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)- 439081-18-2 C24H25ClFN5O3 15
Afatinib (D6) 1313874-96-2 C24H19D6ClFN5O3 2

Recommended Products in Same Target

Name CAS Formula Suppliers
Ginsenoside Rh2 78214-33-2 C36H62O8 8
Mutated EGFR-IN-1 1421372-66-8 C25H31N7O 8
AZD-9291 (mesylate) 1421373-66-1 C29H37N7O5S 6
Mutant EGFR inhibitor 1421373-62-7 C27H30ClN7O2 7
AZD-9291 1421373-65-0 C28H33N7O2 18
WHI-P180 (hydrochloride) 153437-55-9 C16H16ClN3O3 5
WHI-P180 211555-08-7 C16H15N3O3 8
Gefitinib (hydrochloride) 184475-55-6 C22H25Cl2FN4O3 8
Erlotinib (mesylate) 248594-19-6 C23H27N3O7S 5
BGB-102 807640-87-5 C22H25BrN4O2 6
Poziotinib 1092364-38-9 C23H21Cl2FN4O3 12
CO-1686 (hydrobromide) 1446700-26-0 C27H29BrF3N7O3 12
CO-1686 1374640-70-6 C27H28F3N7O3 12
CNX-2006 1375465-09-0 C26H27F4N7O2 10
PD168393 194423-15-9 C17H13BrN4O 13
AG 18 118409-57-7 C10H6N2O2 16
Chrysophanol 481-74-3 C15H10O4 20
AG-1478 153436-53-4 C16H14ClN3O2 12
Mubritinib 366017-09-6 C25H23F3N4O2 24
AST-1306 (TsOH) 1050500-29-2 C31H26ClFN4O5S 13

Recommended Products in the Same Indication

Name CAS Formula Suppliers
LDK378 1032900-25-6 C28H36ClN5O3S 12
Pemetrexed (disodium) 150399-23-8 C20H19N5Na2O6 22
Volasertib 755038-65-4 C34H50N8O3 10
ALK inhibitor 1 761436-81-1 C23H28BrN7O3S 6
Olaparib 763113-22-0 C24H23FN4O3 13
MGCD-265 analog 875337-44-3 C26H20FN5O2S2 7
AT-101 90141-22-3 C30H30O8 15
Tivantinib 905854-02-6 C23H19N3O2 10
Sunitinib 557795-19-4 C22H27FN4O2 18
Motesanib (Diphosphate) 857876-30-3 C22H29N5O9P2 11
Racecadotril 81110-73-8 C21H23NO4S 18
LY2603618 911222-45-2 C18H22BrN5O3 8
Crizotinib 877399-52-5 C21H22Cl2FN5O 21
Ganetespib 888216-25-9 C20H20N4O3 13
Axitinib 319460-85-0 C22H18N4OS 18
Carboplatin 41575-94-4 C6H12N2O4Pt 24
Lenvatinib 417716-92-8 C21H19ClN4O4 7
AXL1717 477-47-4 C22H22O8 18
Afatinib (BIBW 2992) 439081-18-2 C24H25ClFN5O3 9
Vandetanib (hydrochloride) 524722-52-9 C22H25BrClFN4O2 6

Chemical and Physical Properties

Appearance:White to off-white solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

Tags: buy Afatinib (dimaleate) | Afatinib (dimaleate) IC50 | Afatinib (dimaleate) price | Afatinib (dimaleate) cost | Afatinib (dimaleate) solubility | Afatinib (dimaleate) purchase | Afatinib (dimaleate) manufacturer | Afatinib (dimaleate) research buy | Afatinib (dimaleate) order | Afatinib (dimaleate) MSDS | Afatinib (dimaleate) chemical structure | Afatinib (dimaleate) Storage condition | Afatinib (dimaleate) molecular weight | Afatinib (dimaleate) mw | Afatinib (dimaleate) datasheet | Afatinib (dimaleate) supplier | Afatinib (dimaleate) cell line | Afatinib (dimaleate) NMR | Afatinib (dimaleate) MS | Afatinib (dimaleate) IR | Afatinib (dimaleate) solubility | Afatinib (dimaleate) Safe information | Afatinib (dimaleate) Qc and Spectral Information | Afatinib (dimaleate) Clinical Information | Afatinib (dimaleate) Clinical Trial | Afatinib (dimaleate) Route of Synthesis | Afatinib (dimaleate) storage condition | Afatinib (dimaleate) diseases and conditions | Afatinib (dimaleate) flash point | Afatinib (dimaleate) boiling point | Afatinib (dimaleate) melting point | Afatinib (dimaleate) storage condition | Afatinib (dimaleate) brand