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Naloxone (hydrochloride)

(CAS: 357-08-4)

Suppliers of Naloxone (hydrochloride)

Company Name Email Tel Country
AbMole BioScience [email protected] 1-800-660-8580 USA

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Abcam [email protected] (888) 77-ABCAM (22226) USA

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Price and Availability: USD99/250mg ()

Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

Beijing Hony Biopharma Technology Co., Ltd. [email protected] +86 (10) 6125-2983 / 6125-2985 / +86 13611224507 China

Fax: +86 (10) 6125-2196Purity: Brand:

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 0.98 Brand: Biochempartner

Carbosynth Limited [email protected] +44 (1635) 578-444

Fax: +44 (1635) 579-444Purity: Brand:

Price and Availability: USD55/100mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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Price and Availability: USD25/50mg ()

Clearsynth Labs Limited [email protected] Worldwide Helpline No. +1-415-685-4395; US & Canada (Toll-free) : +1-800-650-8239; Europe : +44-20-3286-0885; India : +91-22-26355700 India

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Price and Availability: USD100/25mg ()

Haikou Hengkangda Chemical Co., Ltd. [email protected] +86 (898) 3198-9500 China

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McTony Bio&Chem Inc. [email protected] 604 249 2899 CANADA

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MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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Santa Cruz Biotechnology, Inc. [email protected] Toll Free: 800-457-3801 Phone: 214-902-3900 USA

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Price and Availability: USD31/50mg ()

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: Brand:

Price and Availability: USD97/50mg (In stock) USD130/10mM/1mLIn DMSO (In stock) USD163/10mM(in 1mL DMSO) (in 1mL DMSO)
Quality Control & MSDS Files: HNMR HPLC HNMR HPLC

Shanghai Qiao Chemical Science Co., Ltd. [email protected],[email protected] +86 (21) 5039-6381 / 5094-0968 / 5039-6383 China

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Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .979 Brand: TargetMol

Price and Availability: USD20/2mg () USD67/10mg () USD169/50mg () USD268/100mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

Fax: +1 (636) 207-7683Purity: Brand:

Price and Availability: USD95/100mg ()

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Background Information of Naloxone (hydrochloride)

Naloxone Hcl is a widely used opioid antagonist with an IC50 value of 3 nM (antagonized ACTH stimulation of cortisol). IC50 Value: 3 nM Target: Opioid receptor Opioid-related constipation is one of the most frequent side effects of chronic pain treatment.

Solubility of Naloxone (hydrochloride)

Solubility Sources
(25°C) * In vitro DMSO 73 mg/mL (200.63 mM); Water73 mg/mL (200.63 mM); Ethanol<1 mg/mL (<1 mM) Selleck Chemicals LLC

Storage Condition of Naloxone (hydrochloride)

Storage Condition Sources

MSDS Information

MSDS Sources

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Neuronal Signaling GPCR/G Protein
Target Opioid Receptor
Research Area Neurological Disease
Indications Pain Back pain Cancer pain

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Naloxone (hydrochloride) - Phase 1 Clinical
Naloxone (hydrochloride) US Department of Veterans Affairs Pain 2013/7/31 2014/7/31 Phase 4 Clinical
Naloxone (hydrochloride) Reckitt Benckiser Pharmaceuticals Inc 2012/8/31 2013/8/01 Phase 4 Clinical
Naloxone (hydrochloride) State University of New York Back pain 2012/2/29 2014/5/31 Phase 4 Clinical
Naloxone (hydrochloride) Mundipharma Pte Ltd Cancer pain 2011/5/31 2013/7/31 Phase 4 Clinical
Naloxone (hydrochloride) Mundipharma International Corp Ltd Pain 2010/3/31 2010/10/17 Phase 4 Clinical
Naloxone (hydrochloride) - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
363.84 C19H22ClNO4 357-08-4 4,5alpha-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one hydrochloride; (4R,4aS,7aR,12bS)-3-allyl-4a,9-dihydroxy-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one hydrochloride

Structure Information of Naloxone (hydrochloride)

Smiles O[[email protected]@]1(CCC2=O)[[email protected]]3([[email protected]]2O4)C5=C4C(O)=CC=C5C[[email protected]]1N(CC=C)CC3.Cl
InChI InChI=1S/C19H21NO4.ClH/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;/h2-4,14,17,21,23H,1,5-10H2;1H/t14-,17+,18+,19-;/m1./s1

Related Products

Other Form Products of Naloxone (hydrochloride)

Name CAS Formula Suppliers
Naloxone 465-65-6 C19H21NO4 5
Naloxone (hydrochloride dihydrate) 51481-60-8 C19H26ClNO6 6
Naloxone D5 1261079-38-2 C19H16D5NO4 2

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Sufentanil (citrate) 60561-17-3 C28H38N2O9S 3
Nepafenac 78281-72-8 C15H14N2O2 26
Celecoxib 169590-42-5 C17H14F3N3O2S 17
Atomoxetine (hydrochloride) 82248-59-7 C17H22ClNO 29
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Valdecoxib 181695-72-7 C16H14N2O3S 23

Safety Data of Naloxone (hydrochloride)

Hazard Symbols:Xi Risk Statements:36/37/38 Safety Statements:22-24/25-26-36/37/39-36
Transport Information: HS Code: RTECS:
WGK Germany:3

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:200-2050C
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,72 mg/mL(197.88 mM);In vitro:Water,72 mg/mL(197.88 mM);In vitro:Ethanol,Insoluble;
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:206-611-0
Optical Rotation: alpha: yms4,5alpha-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one hydrochloride

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