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Poziotinib

(CAS: 1092364-38-9)

Suppliers of Poziotinib

Company Name Email Tel Country
Active Biochem [email protected]; [email protected] 1-800-857-0985 (USA Toll Free#) USA

Fax: 1-201-884-1288 (USA Fax#)Purity: Brand:

Price and Availability: USD120/5mg (In stock) USD200/10mg (In stock) USD320/25mg (In stock) USD620/50mg (In stock) USD950/100mg (In stock)

AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

Fax: 866-333-9607 (US & Canada Toll Free) +1-323-606-8156 (Outside of US & Canada)Purity: Brand:

Price and Availability: USD72/5mg ()

BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

Fax: 408-493-1801Purity: Brand:

Price and Availability: USD125/10mg ()

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: >98% Brand: Chemscene

DC Chemicals [email protected]; [email protected] +86-21-58447131 China

Fax: +86-21-61642470Purity: Brand:

Price and Availability: USD450/100mg (In stock)

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: >98% Brand: MedChemExpress

Price and Availability: USD80/5mg (In stock) USD110/10mg (In stock) USD390/50mg (In stock) USD590/100mg (In stock)
Quality Control & MSDS Files: HNMR NP-HPLC LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: Brand:

Price and Availability: USD90/5mg ()

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: Brand:

Price and Availability: USD147/5mg (In stock) USD477/25mg (In stock) USD997/100mg (In stock)

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: >98% Brand:

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: 1 Brand: TargetMol

Price and Availability: USD74/2mg () USD106/5mg () USD171/10mg () USD318/25mg () USD528/50mg ()

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Background Information of Poziotinib

Solubility of Poziotinib

Solubility Sources
10 mM in DMSO CHEMSCENE, LLC
10 mM in DMSO MedChemexpress Co., Ltd.

Storage Condition of Poziotinib

Storage Condition Sources
Store in a tightly closed container, in a cool and dry place. MedChemexpress Co., Ltd.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [NP-HPLC] [LCMS] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways JAK/STAT Signaling Protein Tyrosine Kinase/RTK
Target EGFR
Research Area Cancer
Indications Increased Drug Resistance HER-2 Positive Advanced Gastric Cancer

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Poziotinib National OncoVenture Increased Drug Resistance 2012/10/22 Phase 2 Clinical
Poziotinib Hanmi Pharmaceutical Company Limited HER-2 Positive Advanced Gastric Cancer 2012/12/03 Phase 2 Clinical
Poziotinib - Phase 2

Chemical Information

M.Wt Formula CAS No. Synonyms
491.34 C23H21Cl2FN4O3 1092364-38-9 UNII-OEI6OOU6IK; 1-(4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)prop-2-en-1-one

Structure Information of Poziotinib

Smiles C=CC(N1CCC(OC2=CC3=C(NC4=CC=C(Cl)C(Cl)=C4F)N=CN=C3C=C2OC)CC1)=O
InChI InChI=1S/C23H21Cl2FN4O3/c1-3-20(31)30-8-6-13(7-9-30)33-19-10-14-17(11-18(19)32-2)27-12-28-23(14)29-16-5-4-15(24)21(25)22(16)26/h3-5,10-13H,1,6-9H2,2H3,(H,27,28,29)

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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