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(CAS: 1092364-38-9)

Suppliers of Poziotinib

Company Name Email Tel Country
Active Biochem [email protected]; [email protected] 1-800-857-0985 (USA Toll Free#) USA

Fax: 1-201-884-1288 (USA Fax#)Purity: Brand:

Price and Availability: USD120/5mg (In stock) USD200/10mg (In stock) USD320/25mg (In stock) USD620/50mg (In stock) USD950/100mg (In stock)

AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

Fax: 866-333-9607 (US & Canada Toll Free) +1-323-606-8156 (Outside of US & Canada)Purity: Brand:

Price and Availability: USD72/5mg ()

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: Brand: BOC Sciences

BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

Fax: 408-493-1801Purity: Brand:

Price and Availability: USD125/10mg ()

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD96/5mg () USD132/10mg ()

DC Chemicals [email protected]; [email protected] +86-21-58447131 China

Fax: +86-21-61642470Purity: Brand:

Price and Availability: USD450/100mg (In stock)

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD96/5mg () USD132/10mg ()
Quality Control & MSDS Files: HNMR NP-HPLC LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: Brand:

Price and Availability: USD90/5mg ()

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: Brand:

Price and Availability: USD147/5mg (In stock) USD477/25mg (In stock) USD997/100mg (In stock)

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD96/5mg () USD132/10mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: 1 Brand: TargetMol

Price and Availability: USD74/2mg () USD106/5mg () USD171/10mg () USD318/25mg () USD528/50mg ()

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Background Information of Poziotinib

Solubility of Poziotinib

Solubility Sources
10 mM in DMSO MedChemexpress Co., Ltd.

Storage Condition of Poziotinib

Storage Condition Sources
Store in a tightly closed container, in a cool and dry place. MedChemexpress Co., Ltd.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [NP-HPLC] [LCMS] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways JAK/STAT Signaling Protein Tyrosine Kinase/RTK
Target EGFR
Research Area Cancer
Indications Increased Drug Resistance HER-2 Positive Advanced Gastric Cancer

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Poziotinib National OncoVenture Increased Drug Resistance 2012/10/22 Phase 2 Clinical
Poziotinib Hanmi Pharmaceutical Company Limited HER-2 Positive Advanced Gastric Cancer 2012/12/03 Phase 2 Clinical
Poziotinib - Phase 2

Chemical Information

M.Wt Formula CAS No. Synonyms
491.34 C23H21Cl2FN4O3 1092364-38-9 UNII-OEI6OOU6IK; 1-(4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)prop-2-en-1-one

Structure Information of Poziotinib

Smiles C=CC(N1CCC(OC2=CC3=C(NC4=CC=C(Cl)C(Cl)=C4F)N=CN=C3C=C2OC)CC1)=O
InChI InChI=1S/C23H21Cl2FN4O3/c1-3-20(31)30-8-6-13(7-9-30)33-19-10-14-17(11-18(19)32-2)27-12-28-23(14)29-16-5-4-15(24)21(25)22(16)26/h3-5,10-13H,1,6-9H2,2H3,(H,27,28,29)

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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