• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

Sildenafil (citrate)

(CAS: 171599-83-0)

Suppliers of Sildenafil (citrate)

Company Name Email Tel Country
AbMole BioScience [email protected] 1-800-660-8580 USA

Fax: Purity: Brand:

Abcam [email protected] (888) 77-ABCAM (22226) USA

Fax: (877) 774-8286 / (617) 577-4201Purity: Brand:

Price and Availability: USD491/50mg ()

Adipogen Corporation [email protected] (858) 457-8383 USA

Fax: (858) 457-8484Purity: Brand:

Adipogen Corporation [email protected] (858) 457-8383 USA

Fax: (858) 457-8484Purity: Brand:

Alfa Chemistry [email protected] 1-201-478-8534 USA

Fax: 1-516-927-0118Purity: 98% Brand: Alfa Chemistry

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: Brand:

Astatech, Inc. [email protected] +1 (215) 785-3197 USA

Fax: +1 (215) 785-2656Purity: Brand:

Avanztec Inc. [email protected] +1 800-350-4601 USA

Fax: Purity: Brand:

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

Fax: 408-493-1801Purity: Brand:

Price and Availability: USD335/50mg ()

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 0.98 Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD50/50mg () USD70/100mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

Fax: (734) 971-3640Purity: Brand:

Hangzhou Shenying Medicine Chemical Co., Ltd. [email protected] +86 (571) 8210-6688 China

Fax: +86 (571) 8212-7522Purity: Brand:

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD50/50mg () USD70/100mg ()
Quality Control & MSDS Files: HNMR LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: Brand:

SOCOSUR Distribution Company [email protected] +33 (1) 4772-0075 France

Fax: Purity: Brand:

Santa Cruz Biotechnology, Inc. [email protected] Toll Free: 800-457-3801 Phone: 214-902-3900 USA

Fax: 214-358-6070Purity: Brand:

Price and Availability: USD146/50mg ()

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: Brand:

Price and Availability: USD70/25mg (In stock) USD90/10mM/1mLIn DMSO (In stock) USD110/50mg (In stock) USD670/500mg (In stock)
Quality Control & MSDS Files: HNMR HPLC HPLC HPLC HNMR HPLC HNMR HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD50/50mg () USD70/100mg ()

Sigma-Aldrich, Inc. [email protected] +86 (21) 6141-5566 / 800-819-3336 USA

Fax: Purity: Brand:

Price and Availability: USD82/5mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD20/2mg () USD70/10mg () USD118/25mg () USD198/50mg () USD348/100mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

Fax: +1 (636) 207-7683Purity: Brand:

Price and Availability: USD149/10mg ()

Xiangfan Goto Chemical Co., Ltd [email protected] +86-710-3423122 3423123 CHINA

Fax: +86-710-3423124 3454978Purity: Brand:

Inquiry Online

Salutation: *Country:
*Customer: *Company Name:
*Email: *Request quantity:
Remarks:
 

Notice: Your contact information will be sent to selected suppliers.

* Required Fields.

Background Information of Sildenafil (citrate)

Sildenafil citrate, one of the selective phosphodiesterase-5 (PDE5) inhibitors(IC50= 5.22 nM), is considered the best treatment for erectile dysfunction. IC50 Value: 5.22 nM [1] Target: PDE 5 in vitro: Pretreatment with 1 umol/L sildenafil potentiated the phosphorylation of ERK1/ERK2, an increase in the percentage of cells in S phase and cell proliferation, compared with serotonin stimulation alone (P < 0.05) [2].

Solubility of Sildenafil (citrate)

Solubility Sources
DMSO 23 mg/mL; Water <1 mg/mL; Ethanol <1 mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 20 mg/mL warming (29.99 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM); In vivo 30% PEG400+0.5% Tween80+5% Propylene glycol30 mg/mL Selleck Chemicals LLC

Storage Condition of Sildenafil (citrate)

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.
[HNMR] [HPLC] Selleck Chemicals LLC

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Sildenafil (citrate) The University Health Network Pulmonary artery hypertension 2012/10/31 2016/11/01 Phase 4 Clinical
Sildenafil (citrate) All India Institute of Medical Sciences Pulmonary hypertension 2011/8/31 2013/7/31 Phase 4 Clinical
Sildenafil (citrate) Rabin Medical Center Chronic obstructive pulmonary disease 2011/9/30 2013/9/30 Phase 4 Clinical
Sildenafil (citrate) Pfizer Inc Pulmonary artery hypertension 2011/7/31 2011/10/31 Phase 4 Clinical
Sildenafil (citrate) Rambam Health Care Campus Erectile dysfunction 2011/6/30 2012/7/31 Phase 4 Clinical
Sildenafil (citrate) - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
666.7 C28H38N6O11S 171599-83-0 1-[[3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate; 5-(2-ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(4H)-one 2-hydroxypropane-1,2,3-tricarboxylate

Structure Information of Sildenafil (citrate)

Smiles O=C1N=C(NC(C(CCC)=N2)=C1N2C)C3=CC(S(N4CCN(C)CC4)(=O)=O)=CC=C3OCC.OC(CC(O)=O)(C(O)=O)CC(O)=O
InChI InChI=1S/C22H30N6O4S.C6H8O7/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28;7-3(8)1-6(13,5(11)12)2-4(9)10/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

Related Products

Other Form Products of Sildenafil (citrate)

Name CAS Formula Suppliers
Sildenafil 139755-83-2 C22H30N6O4S 19

Recommended Products in Same Target

Name CAS Formula Suppliers
(R)-(-)-Rolipram 85416-75-7 C16H21NO3 12
Mirodenafil (dihydrochloride) 862189-96-6 C26H39Cl2N5O5S 7
Vardenafil (hydrochloride) 224785-91-5 C23H33ClN6O4S 8
Ibudilast 50847-11-5 C14H18N2O 18
Pentoxifylline 6493-05-6 C13H18N4O3 13
Anagrelide (hydrochloride) 58579-51-4 C10H8Cl3N3O 15
Vardenafil 224785-90-4 C23H32N6O4S 16
(S)-(+)-Rolipram 85416-73-5 C16H21NO3 10
Irsogladine (maleate) 84504-69-8 C13H11Cl2N5O4 14
Irsogladine 57381-26-7 C9H7Cl2N5 14
Dipyridamole (hydrochloride)(1:x) 35763-39-4 C24H41ClN8O4 1
Dipyridamole 58-32-2 C24H40N8O4 20
Pimobendan (hydrochloride) 77469-98-8 C19H19ClN4O2 6
Pimobendan 74150-27-9 C19H18N4O2 20
Aminophylline 317-34-0 C16H24N10O4 19
Diphylline 479-18-5 C10H14N4O4 19
Cilostazol 73963-72-1 C20H27N5O2 30
Deltarasin (hydrochloride) 1440898-82-7 C40H38ClN5O 11
Rolipram 61413-54-5 C16H21NO3 23
Deltarasin 1440898-61-2 C40H37N5O 12

Recommended Products in the Same Indication

Name CAS Formula Suppliers
sitaxsentan 184036-34-8 C18H15ClN2O6S2 7
Carvedilol 72956-09-3 C24H26N2O4 22
PRX-08066 866206-54-4 C19H17ClFN5S 9
SCH 527123 473727-83-2 C21H23N3O5 14
Vilanterol 503068-34-6 C24H33Cl2NO5 8
PH-797804 586379-66-0 C22H19BrF2N2O3 13
Glycopyrrolate 596-51-0 C19H28BrNO3 21
Tolazoline 59-98-3 C10H12N2 11
Umeclidinium (bromide) 869113-09-7 C29H34BrNO2 12
Indacaterol 312753-06-3 C24H28N2O3 24
Aclidinium (Bromide) 320345-99-1 C26H30BrNO4S2 15
Vilanterol (trifenatate) 503070-58-4 C44H49Cl2NO7 11
Formoterol 67346-49-0 C19H24N2O4 7
Tadalafil 171596-29-5 C22H19N3O4 29
Milrinone 78415-72-2 C12H9N3O 27
Formoterol (Fumarate) 43229-80-7 C19H24N2O4.1/2C4H4O4<䲧甙Ỵ甚 17
Macitentan 441798-33-0 C19H20Br2N6O4S 15
Riociguat 625115-55-1 C20H19FN8O2 11
Sildenafil 139755-83-2 C22H30N6O4S 19
Yohimbine 146-48-5 C21H26N2O3 27

Safety Data of Sildenafil (citrate)

Hazard Symbols:Xi Risk Statements:36/37/38 Safety Statements:36
Transport Information: HS Code: RTECS:
WGK Germany:

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:187-189°C
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,20 mg/mLwarmed(29.99 mM);In vitro:Water,Insoluble;In vitro:Ethanol,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):30% PEG400+0.5% Tween80+5% propylene glycolFor best r
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

Tags: buy Sildenafil (citrate) | Sildenafil (citrate) IC50 | Sildenafil (citrate) price | Sildenafil (citrate) cost | Sildenafil (citrate) solubility | Sildenafil (citrate) purchase | Sildenafil (citrate) manufacturer | Sildenafil (citrate) research buy | Sildenafil (citrate) order | Sildenafil (citrate) MSDS | Sildenafil (citrate) chemical structure | Sildenafil (citrate) Storage condition | Sildenafil (citrate) molecular weight | Sildenafil (citrate) mw | Sildenafil (citrate) datasheet | Sildenafil (citrate) supplier | Sildenafil (citrate) cell line | Sildenafil (citrate) NMR | Sildenafil (citrate) MS | Sildenafil (citrate) IR | Sildenafil (citrate) solubility | Sildenafil (citrate) Safe information | Sildenafil (citrate) Qc and Spectral Information | Sildenafil (citrate) Clinical Information | Sildenafil (citrate) Clinical Trial | Sildenafil (citrate) Route of Synthesis | Sildenafil (citrate) storage condition | Sildenafil (citrate) diseases and conditions | Sildenafil (citrate) flash point | Sildenafil (citrate) boiling point | Sildenafil (citrate) melting point | Sildenafil (citrate) storage condition | Sildenafil (citrate) brand