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SB-505124 (hydrochloride)

(CAS: 356559-13-2)

Suppliers of SB-505124 (hydrochloride)

Company Name Email Tel Country
AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

Fax: 866-333-9607 (US & Canada Toll Free) +1-323-606-8156 (Outside of US & Canada)Purity: Brand:

Price and Availability: USD80/10mg ()

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: Brand:

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD144/10mg () USD504/50mg ()

EMD Millipore USA

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Price and Availability: USD146/2mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD144/10mg () USD504/50mg ()

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD144/10mg () USD504/50mg ()

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Background Information of SB-505124 (hydrochloride)

SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5 with IC50 of 129 nM and 47 nM, respectively, also inhibits ALK7, but does not inhibit ALK1, 2, 3, or 6. IC50 Value: 47 ± 5 nM (ALK5); 129 ± 11 nM (ALK4) [1] Target: ALK4/5 in vitro: SB-505124 was identified as a potent inhibitor of the in vitro kinase activity of ALK5 for its substrate Smad3 with an IC50 of 47 ± 5 nM.

Solubility of SB-505124 (hydrochloride)

Solubility Sources
DMSO MedChemexpress Co., Ltd.

Storage Condition of SB-505124 (hydrochloride)

Storage Condition Sources

MSDS Information

MSDS Sources

Quality Control and Spectral Data

QC Reports Sources

Mechanism and Indications

Signaling Pathways TGF-beta/Smad
Target TGF-β Receptor
Research Area Cancer
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
SB-505124 (hydrochloride) - Not Found
SB-505124 (hydrochloride) - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
371.86 C20H22ClN3O2 356559-13-2 SB 505124 hydrochloride;SB505124 hydrochloride; 2-(4-(benzo[d][1,3]dioxol-5-yl)-2-(tert-butyl)-1H-imidazol-5-yl)-6-methylpyridine hydrochloride

Structure Information of SB-505124 (hydrochloride)

Smiles CC1=CC=CC(C2=C(C3=CC=C(OCO4)C4=C3)N=C(C(C)(C)C)N2)=N1.[H]Cl
InChI InChI=1S/C20H21N3O2.ClH/c1-12-6-5-7-14(21-12)18-17(22-19(23-18)20(2,3)4)13-8-9-15-16(10-13)25-11-24-15;/h5-10H,11H2,1-4H3,(H,22,23);1H

Related Products

Other Form Products of SB-505124 (hydrochloride)

Name CAS Formula Suppliers
SB-505124 694433-59-5 C20H21N3O2 14

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Chemical and Physical Properties

Appearance: Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
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