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Trifluorothymidine

(CAS: 70-00-8)

Suppliers of Trifluorothymidine

Company Name Email Tel Country
Abblis Chemicals LLC [email protected] Toll Free: 1-877-799-4928 (US and Canada only) Tel:+1-877-799-4928 USA

Fax: Fax:+1-713-664-0347Purity: Brand:

Price and Availability: USD110/100mg (In Stock)

AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

Fax: 866-333-9607 (US & Canada Toll Free) +1-323-606-8156 (Outside of US & Canada)Purity: Brand:

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: Brand:

Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

Fax: +1 (847) 367-3681Purity: Brand:

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: Brand: BOC Sciences

Beijing Ribio Biotech. Inc. [email protected],[email protected] +86 (10) 5895-7280 / +86 13910960639 China

Fax: +86 (10) 5895-7290Purity: Brand:

BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

Fax: 408-493-1801Purity: Brand:

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 0.98 Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD84/50mg () USD126/100mg ()

Carbosynth Limited [email protected] +44 (1635) 578-444

Fax: +44 (1635) 579-444Purity: Brand:

Price and Availability: USD50/500mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

Fax: (734) 971-3640Purity: Brand:

Huzhou Hengyuan Biochem. Tech. Co., Ltd. [email protected] +86 (572) 211-6303 / 260-7156 / 260-7159 China

Fax: +86 (572) 260-7155Purity: Brand:

J&K Scientific Ltd. [email protected];[email protected] 400-666-7788 / +86 10 8284 8833 China

Fax: +86 10 8284 9933Purity: Brand:

Price and Availability: RMB922/100mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD84/50mg () USD126/100mg ()
Quality Control & MSDS Files: LCMS NP-HPLC HNMR MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: Brand:

Santa Cruz Biotechnology, Inc. [email protected] Toll Free: 800-457-3801 Phone: 214-902-3900 USA

Fax: 214-358-6070Purity: Brand:

Price and Availability: USD179/100mg ()

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: Brand:

Price and Availability: USD97/50mg (In stock) USD130/10mM/1mLIn DMSO (In stock)
Quality Control & MSDS Files: HNMR HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD84/50mg () USD126/100mg ()

Shanghai MEG Biochemical Co., Ltd. [email protected] +86 (21) 5108-2199 China

Fax: +86 (21) 5027-6058Purity: Brand:

Sigma-Aldrich, Inc. [email protected] +86 (21) 6141-5566 / 800-819-3336 USA

Fax: Purity: Brand:

Price and Availability: USD184/100mg ()

Spectrum Chemical Mfg. Corp. [email protected] +1 (310) 516-8000 USA

Fax: +1 (310) 516-7512Purity: Brand:

Price and Availability: USD133/100mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .97 Brand: TargetMol

Price and Availability: USD20/2mg () USD80/10mg () USD132/50mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

Fax: +1 (636) 207-7683Purity: Brand:

Price and Availability: USD99/50mg ()

Tokyo Chemical Industry Co., Ltd. [email protected] 03-3668-0489 Japan

Fax: 03-3668-0520Purity: Brand:

Price and Availability: USD107/100mg ()

Tongchem Co., Limited [email protected] 0086-755-83180486 CHINA

Fax: 0086-755-83180406Purity: Brand:

Zhejiang Esun Chemical Co., Ltd. [email protected] +86 (571) 5628-6531 China

Fax: +86 (571) 5628-7608Purity: Brand:

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Background Information of Trifluorothymidine

Trifluorothymidine (TFT) and is an inhibitor of thymidine phosphorylase.

Solubility of Trifluorothymidine

Solubility Sources
DMSO MedChemexpress Co., Ltd.
DMSO 59 mg/mL (199 mM) ; Water 59 mg/mL (199 mM) ; Ethanol 59 mg/mL (199 mM) Selleck Chemicals LLC

Storage Condition of Trifluorothymidine

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [NP-HPLC] [HNMR] MedChemexpress Co., Ltd.
[HNMR] [HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Cell Cycle/DNA Damage Apoptosis
Target Thymidylate Synthase Nucleoside Antimetabolite/Analog
Research Area Cancer
Indications Advanced solid tumor

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Trifluorothymidine Taiho Pharmaceutical Co Ltd Advanced solid tumor 2013/7/31 2014/6/30 Phase 1 Clinical
Trifluorothymidine - Pre-registration
Trifluorothymidine - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
296.2 C10H11F3N2O5 70-00-8 2'-Deoxy-5-(trifluoromethyl)uridine; 5-(Trifluoromethyl)-2'-deoxyuridine; Trifluorothymine deoxyriboside; Trifluorothymidine; 1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione

Structure Information of Trifluorothymidine

Smiles O=C(N1)N(C=C(C(F)(F)F)C1=O)[[email protected]@H](C[[email protected]@H]2O)O[[email protected]@H]2CO
InChI InChI=1S/C10H11F3N2O5/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7/h2,5-7,16-17H,1,3H2,(H,14,18,19)/t5-,6+,7+/m0/s1

Related Products

Other Form Products of Trifluorothymidine

Name CAS Formula Suppliers

Recommended Products in Same Target

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TAS-102 733030-01-8 C10H11F3N2O5 . 1/2C9H11ClN4O2 . 1/2HCl 5
5-BrdU 59-14-3 C9H11BrN2O5 28
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Adenosine 58-61-7 C10H13N5O4 33
Carmofur 61422-45-5 C11H16FN3O3 15
Cytidine 65-46-3 C9H13N3O5 28
Merimepodib 198821-22-6 C23H24N4O6 11
Floxuridine 50-91-9 C9H11FN2O5 27
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Tipiracil (hydrochloride) 183204-72-0 C9H12Cl2N4O2 15
Orotic acid 65-86-1 C5H4N2O4 19
Nelarabine 121032-29-9 C11H15N5O5 22
6-Mercaptopurine 50-44-2 C5H4N4S 25
LY2334737 892128-60-8 C17H25F2N3O5 10
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Gemcitabine (elaidate) 210829-30-4 C27H43F2N3O5 10

Recommended Products in the Same Indication

Name CAS Formula Suppliers
OSI-930 728033-96-3 C22H16F3N3O2S 14
AT7867 857531-00-1 C20H20ClN3 15
NVP-BGJ398 872511-34-7 C26H31Cl2N7O3 20
BMS-599626 (Hydrochloride) 873837-23-1 C27H28ClFN8O3 12
RO4987655 874101-00-5 C20H19F3IN3O5 16
MGCD-265 analog 875337-44-3 C26H20FN5O2S2 14
Regorafenib (Hydrochloride) 835621-07-3 C21H16Cl2F4N4O3 10
AT9283 896466-04-9 C19H23N7O2 21
KX2-391 897016-82-9 C26H29N3O3 14
MLN4924 905579-51-3 C21H25N5O4S 16
SNX-2112 908112-43-6 C23H27F3N4O3 12
ABC294640 915385-81-8 C23H25ClN2O 9
OTSSP167 1431697-89-0 C25H28Cl2N4O2 12
MK-0752 471905-41-6 C21H21ClF2O4S 16
ZSTK474 475110-96-4 C19H21F2N7O2 20
BMS-599626 714971-09-2 C27H27FN8O3 14
PHA-848125 802539-81-7 C25H32N8O 15
17-AAG (Hydrochloride) 911710-03-7 C31H44ClN3O8 7
Veliparib 912444-00-9 C13H16N4O 11
Veliparib (dihydrochloride) 912445-05-7 C13H18Cl2N4O 8

Safety Data of Trifluorothymidine

Hazard Symbols:Xi Risk Statements:R20/21/22;R40 Safety Statements:S22;S36
Transport Information: HS Code: RTECS:XP2087500
WGK Germany:3

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:190-193 °C(lit.)
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,59 mg/mL(199.18 mM);In vitro:Water,59 mg/mLwarmed(199.18 mM);In vitro:Ethanol,59 mg/mL(199.18 mM);
Density: Merck:9687
BRN: Refractive Index: 50 ° (C=1, H2O)
Vapour: EINECS:200-722-8
Optical Rotation: alpha:

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