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A 419259

(CAS: 364042-47-7)

Suppliers of A 419259

Company Name Email Tel Country
BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: >98% Brand:

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: >98% Brand:

Price and Availability: USD180/10mg (Get quote) USD630/50mg (Get quote)

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: >98% Brand:

Price and Availability: USD195/10mg (Get quote) USD580/50mg (Get quote)

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Background Information of A 419259

A 419259(RK 20449) is an apoptosis inducing agent that inhibits Src family kinases (c-Src); A 419259 also induces apoptosis in CML cell ines and blocks Stat5 and Erk activation. IC50 Value: 9 nM (Src); <3 nM (Lck); <3 nM (Lyn); 3 uM (Abl) [1] Target: Src family kinase in vitro: Treatment of the Ph+ CML cell lines K-562 and Meg-01 with A-419259 resulted in growth arrest and induction of apoptosis, while the Ph- leukemia cell lines TF-1 and HEL were unaffected over the same concentration ranges.

Solubility of A 419259

Solubility Sources
DMSO MedChemexpress Co., Ltd.

Storage Condition of A 419259

Storage Condition Sources

MSDS Information

MSDS Sources

Quality Control and Spectral Data

QC Reports Sources

Mechanism and Indications

Signaling Pathways Protein Tyrosine Kinase/RTK
Target Src
Research Area Cancer
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
A 419259 - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
482.62 C29H34N6O 364042-47-7 A419259;A-419259;RK 20449;RK20449;RK-20449; 7-((1r,4r)-4-(4-methylpiperazin-1-yl)cyclohexyl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Structure Information of A 419259

Smiles NC1=C2C(N([[email protected]]3CC[[email protected]](N4CCN(C)CC4)CC3)C=C2C5=CC=C(OC6=CC=CC=C6)C=C5)=NC=N1
InChI InChI=1S/C29H34N6O/c1-33-15-17-34(18-16-33)22-9-11-23(12-10-22)35-19-26(27-28(30)31-20-32-29(27)35)21-7-13-25(14-8-21)36-24-5-3-2-4-6-24/h2-8,13-14,19-20,22-23H,9-12,15-18H2,1H3,(H2,30,31,32)/t22-,23-

Related Products

Other Form Products of A 419259

Name CAS Formula Suppliers
A 419259 (trihydrochloride) 1435934-25-0 C29H37Cl3N6O 9

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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