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Adapalene

(CAS: 106685-40-9)

Suppliers of Adapalene

Company Name Email Tel Country
AOBIOUS INC [email protected] (508) 306-0937 USA

Fax: Purity: Brand:

Price and Availability: USD11/1mg ()

AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

Fax: 866-333-9607 (US & Canada Toll Free) +1-323-606-8156 (Outside of US & Canada)Purity: Brand:

Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

Fax: +1 (847) 367-3681Purity: Brand:

Asia Talent Chemical Limited [email protected],[email protected],[email protected] +86 (755) 8665-5561 China

Fax: +86 (755) 8665-5591Purity: Brand:

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

Beijing Dezhong Wanquan Medicines Technological Development Co., Ltd. [email protected] +86 (10) 8850-0088 ex 206 China

Fax: +86 (10) 8850-0080Purity: Brand:

Beijing FaMuRuiSi Pharmaceuticals Co., Ltd. [email protected] +86 (10) 6125-2196 / +86 18901358086 China

Fax: +86 (10) 6125-2196Purity: Brand:

Beijing Mediking Biopharm Co., Ltd. [email protected],[email protected] +86 (10) 8176-9521 / 8975-3524 China

Fax: +86 (10) 8176-9652Purity: Brand:

Beijing Mesochem Technology Co., Ltd. [email protected],[email protected] +86 (10) 6540-5760 / 6737-4028 / +86 13366977697 China

Fax: +86 (10) 6571-2882Purity: Brand:

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 0.98 Brand: Biochempartner

Broad Pharmaceutical Co., Ltd. [email protected] +86 (10) 5173-3671 / 5173-3670 / 5173-3669 China

Fax: +86 (10) 5173-3671Purity: Brand:

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD60/50mg () USD96/100mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

Fax: (734) 971-3640Purity: Brand:

Dyna International (Huaian) Co., Ltd [email protected] 86-517-3750055 CHINA

Fax: 86-517-3922055Purity: Brand:

Hangzhou Best Chemical Co., Ltd. [email protected] +86 (571) 8848-0018 China

Fax: +86 (571) 8848-0028Purity: Brand:

Hangzhou Hysen Pharma Co., Ltd. [email protected] +86 (571) 8829-8691 China

Fax: +86 (571) 2891-8299Purity: Brand:

Hubei Widely Chemical Technology Co., Ltd. [email protected] +86 (27) 8398-9310 China

Fax: +86 (27) 8398-9310Purity: Brand:

Huzhou Hengyuan Biochem. Tech. Co., Ltd. [email protected] +86 (572) 211-6303 / 260-7156 / 260-7159 China

Fax: +86 (572) 260-7155Purity: Brand:

Jiangsu Zhongdan Group Co., Ltd. [email protected] +86 (523) 8798-3888 China

Fax: Purity: Brand:

Jinan Chuancheng Pharmaceutical Co., Ltd. [email protected] +86 (531) 8890-2485 China

Fax: +86 (531) 8890-2485Purity: Brand:

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD60/50mg () USD96/100mg ()
Quality Control & MSDS Files: HNMR MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: Brand:

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: Brand:

Price and Availability: USD97/25mg (In stock) USD130/10mM/1mLIn DMSO (In stock) USD170/50mg (In stock)
Quality Control & MSDS Files: HNMR HPLC HNMR HPLC HNMR HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD60/50mg () USD96/100mg ()

Shanghai RenYoung Pharmaceutical Co., Ltd. [email protected] +86 (21) 3501-0877 China

Fax: +86 (21) 3501-0877Purity: Brand:

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .99 Brand: TargetMol

Price and Availability: USD20/2mg () USD56/10mg () USD108/25mg () USD198/50mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

Fax: +1 (636) 207-7683Purity: Brand:

Wonder Synthesis (Beijing) Science and Development Co., Ltd. [email protected],[email protected] +86 (10) 8482-6062 China

Fax: +86 (10) 8482-6062Purity: Brand:

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Background Information of Adapalene

Adapalene(CD-271; Differin), a synthetic retinoid, is a retinoic acid receptor agonist (RAR). Target: Retinoic acid receptor agonist (RAR) Adapalene is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions.

Solubility of Adapalene

Solubility Sources
DMSO 8 mg/mL; Water <1 mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 8 mg/mL (19.39 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) Selleck Chemicals LLC
Soluble to 25 mM in DMSO Tocris Bioscience Inc.

Storage Condition of Adapalene

Storage Condition Sources
Store at +4°C Tocris Bioscience Inc.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] MedChemexpress Co., Ltd.
[HNMR] [HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Metabolic Enzyme/Protease
Target RAR/RXR
Research Area Inflammation/Immunology
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Adapalene - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
412.52 C28H28O3 106685-40-9 CD 271;CD271;CD-271;Differin; 6-(3-((3r,5r,7r)-adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid

Structure Information of Adapalene

Smiles O=C(C1=CC2=CC=C(C3=CC=C(OC)C(C45C[[email protected]@H](C[[email protected]](C6)C5)C[[email protected]@H]6C4)=C3)C=C2C=C1)O
InChI InChI=1S/C28H28O3/c1-31-26-7-6-23(21-2-3-22-12-24(27(29)30)5-4-20(22)11-21)13-25(26)28-14-17-8-18(15-28)10-19(9-17)16-28/h2-7,11-13,17-19H,8-10,14-16H2,1H3,(H,29,30)/t17-,18+,19-,28?

Related Products

Other Form Products of Adapalene

Name CAS Formula Suppliers
Adapalene (sodium salt) 911110-93-5 C28H27NaO3 5
Hydroxy Adapalene 1346599-76-5 C28H28O4 2

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Acitretin (sodium) 925701-88-8 C21H25NaO3 5
Acitretin 55079-83-9 C21H26O3 22
Adapalene (sodium salt) 911110-93-5 C28H27NaO3 5
TTNPB 71441-28-6 C24H28O2 22
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LG 100268 153559-76-3 C24H29NO2 7
Isotretinoin 4759-48-2 C20H28O2 31
Palovarotene 410528-02-8 C27H30N2O2 10
Retinoic acid 302-79-4 C20H28O2 34
AM580 102121-60-8 C22H25NO3 13
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AGN 195183 367273-07-2 C22H22ClF2NO4 8
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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:319-3220C
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,8 mg/mL(19.39 mM);In vitro:Water,Insoluble;In vitro:Ethanol,Insoluble;
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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