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Bumetanide

(CAS: 28395-03-1)

Suppliers of Bumetanide

Company Name Email Tel Country
Abcam [email protected] (888) 77-ABCAM (22226) USA

Fax: (877) 774-8286 / (617) 577-4201Purity: Brand:

Price and Availability: USD204/1g ()

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

Beijing Kaida Technology Development Co., Ltd. [email protected],[email protected] +86 (10) 6299-3416 / +86 13811060439 China

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 0.98 Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD106/1g () USD432/5g ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

Fax: (734) 971-3640Purity: Brand:

Price and Availability: USD30/500mg ()

Guilin Pharmaceutical Works [email protected] +86 (773) 382-5239 / 355-5660 / (21) 5132-0161 China

Fax: +86 (773) 384-1973 / (21) 5132-0381Purity: Brand:

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD106/1g () USD432/5g ()
Quality Control & MSDS Files: HNMR LCMS MSDS

Pure Chemistry Scientific Inc. [email protected] 857-928-2050 / 857-366-6788 USA

Fax: 617-206-9595Purity: 90% Brand:

Price and Availability: USD26/1g (In stock)

Santa Cruz Biotechnology, Inc. [email protected] Toll Free: 800-457-3801 Phone: 214-902-3900 USA

Fax: 214-358-6070Purity: Brand:

Price and Availability: USD100/1g ()

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: >98% Brand:

Price and Availability: USD97/50mg (In stock) USD130/10mM/1mLIn DMSO (In stock) USD163/10mM(in 1mL DMSO) (in 1mL DMSO)
Quality Control & MSDS Files: HNMR HPLC HPLC HNMR HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD106/1g () USD432/5g ()

Sigma-Aldrich, Inc. [email protected] +86 (21) 6141-5566 / 800-819-3336 USA

Fax: Purity: Brand:

Price and Availability: USD62/250mg ()

Suzhou Lixin Pharmaceutical Co., Ltd. [email protected] +86 (512) 8816-9812 China

Fax: +86 (512) 8816-9811Purity: Brand:

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD20/2mg () USD68/10mg () USD168/50mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

Fax: +1 (636) 207-7683Purity: Brand:

Price and Availability: USD69/50mg ()

VDM BIOCHEMICALS,Inc. [email protected] 1-440-786-9400 USA

Fax: 1-440-786-9410Purity: Brand:

Price and Availability: USD80/10mg (In stock)

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Background Information of Bumetanide

Bumetanide(Ro 10-6338; PF 1593) is an inhibitor of Na(+)-K(+)-2Cl(-) co-transporter (NKCC) with an IC50 of 0.6 uM. IC50 Value: 0.6 uM [1] Target: NKCC (Na-K-Cl cotransporter) in vitro: Cultured chick cardiac cells possess a Na+K+Cl-co-transport system that is inhibited by the "loop diuretics" bumetanide (IC50 = 0.6 microM).

Solubility of Bumetanide

Solubility Sources
DMSO 73 mg/ml; Water <1 mg/ml MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 73 mg/mL (200.31 mM); Ethanol36 mg/mL (98.78 mM); Water<1 mg/mL (<1 mM) Selleck Chemicals LLC

Storage Condition of Bumetanide

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.
[HNMR] [HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Membrane Transporter/Ion Channel
Target NKCC
Research Area Cardiovascular Disease
Indications Congestive heart failure Autism Diabetes mellitus

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Bumetanide Universiteit Hasselt Congestive heart failure 2013/11/30 2016/1/31 Phase 4 Clinical
Bumetanide University Hospital, Brest Autism 2010/3/31 2011/6/30 Phase 3 Clinical
Bumetanide Bristol-Myers Squibb Co Diabetes mellitus 2009/7/31 2009/8/31 Phase 1 Clinical
Bumetanide - Discontinued
Bumetanide - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
364.42 C17H20N2O5S 28395-03-1 Bumex; Burinex; 3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic acid; 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid; 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid

Structure Information of Bumetanide

Smiles NS(C1=CC(C(O)=O)=CC(NCCCC)=C1OC2=CC=CC=C2)(=O)=O
InChI InChI=1S/C17H20N2O5S/c1-2-3-9-19-14-10-12(17(20)21)11-15(25(18,22)23)16(14)24-13-7-5-4-6-8-13/h4-8,10-11,19H,2-3,9H2,1H3,(H,20,21)(H2,18,22,23)

Related Products

Other Form Products of Bumetanide

Name CAS Formula Suppliers
Bumetanide (sodium salt) 28434-74-4 C17H19N2NaO5S 1

Recommended Products in Same Target

Name CAS Formula Suppliers
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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:230-2310C
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:249-004-6
Optical Rotation: alpha:

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