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(CAS: 85081-18-1)

Suppliers of NBI-98782

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Acanthus Research [email protected] +1 (416) 978-4344 USA

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Quality Control & MSDS Files: HNMR NP-HPLC LCMS MSDS

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Background Information of NBI-98782

NBI-98782(alpha-dihydrotetrabenazine) is a vesicular monoamine transporter (VMAT2) inhibtior with an Ki value of 0.97 nM. IC50 value: 0.97± 0.48 nM [1] Target: VMAT2 The (+)-isomer showed high affinity in vitro (Ki = 0.97 +/- 0.48 nM) for the vesicular monoamine transporter (VMAT2) in rat brain striatum, whereas the (-)-isomer was inactive (Ki = 2.2 +/- 0.3 microM).

Solubility of NBI-98782

Solubility Sources
DMSO MedChemexpress Co., Ltd.

Storage Condition of NBI-98782

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [NP-HPLC] [LCMS] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Membrane Transporter/Ion Channel
Target Monoamine Transporter
Research Area Neurological Disease
Indications Tardive dyskinesia Hepatic insufficiency

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
NBI-98782 Neurocrine Biosciences Inc Tardive dyskinesia 2012/12/31 2013/8/31 Phase 2 Clinical
NBI-98782 Neurocrine Biosciences Inc Tardive dyskinesia 2012/9/30 2013/10/31 Phase 2 Clinical
NBI-98782 Neurocrine Biosciences Inc Tardive dyskinesia 2011/1/31 2011/3/31 Phase 2 Clinical
NBI-98782 Neurocrine Biosciences Inc Tardive dyskinesia 2011/8/31 2012/2/29 Phase 2 Clinical
NBI-98782 Neurocrine Biosciences Inc Hepatic insufficiency 2013/8/31 2014/3/31 Phase 1 Clinical
NBI-98782 Neurocrine Biosciences Inc 2013/7/31 2013/8/31 Phase 1 Clinical
NBI-98782 - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
319.44 C19H29NO3 85081-18-1 (2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-ol

Structure Information of NBI-98782

Smiles O[[email protected]]1[[email protected]](CC(C)C)CN2CCC3=CC(OC)=C(OC)C=C3[[email protected]@]2([H])C1
InChI InChI=1S/C19H29NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16-17,21H,5-7,10-11H2,1-4H3/t14-,16-,17-/m1/s1

Related Products

Other Form Products of NBI-98782

Name CAS Formula Suppliers
NBI-98854 171598-74-6 C19H29NO3 5

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Name CAS Formula Suppliers
NBI-98854 171598-74-6 C19H29NO3 5
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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density:1.13 Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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