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NBI-98854

(CAS: 171598-74-6)

Suppliers of NBI-98854

Company Name Email Tel Country
Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: Brand:

Price and Availability: USD333/5mg ()

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: > 95% Brand: BOC Sciences

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD420/5mg () USD600/10mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD420/5mg () USD600/10mg ()

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD420/5mg () USD600/10mg ()

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Background Information of NBI-98854

NBI-98854 is a potent, highly selective, VMAT2 inhibitor that is effective in regulating the levels of dopamine release during nerve communication. IC50 value: Target: VMAT2 NBI-98854 completed a Phase I single ascending dose clinical trial in healthy male volunteers in Canada under an approved Clinical Trial Application with Health Canada.This trial showed NBI-98854 to be generally safe and well tolerated.

Solubility of NBI-98854

Solubility Sources
DMSO MedChemexpress Co., Ltd.

Storage Condition of NBI-98854

Storage Condition Sources

MSDS Information

MSDS Sources

Quality Control and Spectral Data

QC Reports Sources

Mechanism and Indications

Signaling Pathways Membrane Transporter/Ion Channel
Target Monoamine Transporter
Research Area Neurological Disease
Indications Tardive dyskinesia Hepatic insufficiency

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
NBI-98854 Neurocrine Biosciences Inc Tardive dyskinesia 2012/12/31 2013/8/31 Phase 2 Clinical
NBI-98854 Neurocrine Biosciences Inc Tardive dyskinesia 2012/9/30 2013/10/31 Phase 2 Clinical
NBI-98854 Neurocrine Biosciences Inc Tardive dyskinesia 2011/1/31 2011/3/31 Phase 2 Clinical
NBI-98854 Neurocrine Biosciences Inc Tardive dyskinesia 2011/8/31 2012/2/29 Phase 2 Clinical
NBI-98854 Neurocrine Biosciences Inc Hepatic insufficiency 2013/8/31 2014/3/31 Phase 1 Clinical
NBI-98854 Neurocrine Biosciences Inc 2013/7/31 2013/8/31 Phase 1 Clinical
NBI-98854 - Phase 3

Chemical Information

M.Wt Formula CAS No. Synonyms
319.44 C19H29NO3 171598-74-6 NBI98854;NBI 98854;(2R,3R,11bR)-rel-Dihydrotetrabenazine;(2R,3R,11bR)-rel-DHTBZ; (2S,3S,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-ol

Structure Information of NBI-98854

Smiles COC(C=C1CCN2C[[email protected]](CC(C)C)[[email protected]@H](O)C3)=C(C=C1[[email protected]]23[H])OC
InChI InChI=1S/C19H29NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16-17,21H,5-7,10-11H2,1-4H3/t14-,16+,17-/m0/s1

Related Products

Other Form Products of NBI-98854

Name CAS Formula Suppliers
NBI-98782 85081-18-1 C19H29NO3 6

Recommended Products in Same Target

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NBI-98782 85081-18-1 C19H29NO3 6
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Recommended Products in the Same Indication

Name CAS Formula Suppliers
NBI-98782 85081-18-1 C19H29NO3 6
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Chemical and Physical Properties

Appearance: Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
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Optical Rotation: alpha:

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