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Irbesartan

(CAS: 138402-11-6)

Suppliers of Irbesartan

Company Name Email Tel Country
AA Blocks LLC [email protected] +1 858-523-8231

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AOBIOUS INC [email protected] (508) 306-0937 USA

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AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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Alfa Chemistry [email protected] 1-201-478-8534 USA

Fax: 1-516-927-0118Purity: 0.96 Brand: Alfa Chemistry

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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BLD Pharmatech [email protected] +86-21-61629022

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BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 0.98 Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD60/10mg () USD106/50mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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Edengene Chemical Limited [email protected],[email protected] +86 (519) 8520-8709 China

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Guangzhou Winsun Pharmaceutical Co., Ltd. [email protected] +86 (20) 3886-6693 / 3886-6695 China

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Hefei Scenery Chemical Co., Ltd. [email protected] +86 (551) 6512-1814 China

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Hunan Astar Bio-chemicals Technology Co., Ltd. [email protected] +86 (10) 5831-9740 China

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD60/10mg () USD106/50mg ()
Quality Control & MSDS Files: HNMR LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Price and Availability: USD97/10mg (In stock) USD270/50mg (In stock)
Quality Control & MSDS Files: HNMR HPLC HPLC HNMR HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Price and Availability: USD60/10mg () USD106/50mg ()

Shanghai Jinli Chemical Co., Ltd. [email protected],[email protected],[email protected] +86 (21) 6725-6038 / 6725-6056 China

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Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .99 Brand: TargetMol

Price and Availability: USD36/2mg () USD68/10mg () USD145/50mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

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Zhejiang Daoqi Industry & Trade Co., Ltd. [email protected] +86 (576) 8869-8033 China

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Zhejiang Ouhua Chemical Imp. & Exp. Co., Ltd. [email protected] +86 (576) 8882-6717 China

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Background Information of Irbesartan

Irbesartan is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM. Target: Angiotensin Receptor Irbesartan treatment markedly induces the expression of the adipogenic marker gene adipose protein 2 (aP2) in 3T3-L1 cells in a concentration-dependent manner with EC50 of 3.5 μM and 3.3-fold induction at the concentration of 10 μM.

Solubility of Irbesartan

Solubility Sources
DMSO 1 mg/mL (2 mM); Water <1 mg/mL (<1 mM) MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 1 mg/mL (2.33 mM); Ethanol3 mg/mL (7.0 mM); Water<1 mg/mL (<1 mM); In vivo 30% PEG400+0.5% Tween80+5% Propylene glycol30 mg/mL Selleck Chemicals LLC
Purity:&#62;98 % Tocris Bioscience Inc.

Storage Condition of Irbesartan

Storage Condition Sources
Store at +4°C Tocris Bioscience Inc.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.
[HNMR] [HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways GPCR/G Protein
Target Angiotensin Receptor
Research Area Cardiovascular Disease
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Irbesartan - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
428.53 C25H28N6O 138402-11-6 3-Butyl-2-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-2,4-diazaspiro[4.4]non-3-en-1-one; 3-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one

Structure Information of Irbesartan

Smiles O=C1C2(CCCC2)N=C(CCCC)N1CC3=CC=C(C4=CC=CC=C4C5=NN=NN5)C=C3
InChI InChI=1S/C25H28N6O/c1-2-3-10-22-26-25(15-6-7-16-25)24(32)31(22)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)23-27-29-30-28-23/h4-5,8-9,11-14H,2-3,6-7,10,15-17H2,1H3,(H,27,28,29,30)

Related Products

Other Form Products of Irbesartan

Name CAS Formula Suppliers
Irbesartan D4 1216883-23-6 C25H24D4N6O 5

Recommended Products in Same Target

Name CAS Formula Suppliers
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Losartan (potassium) 124750-99-8 C22H22ClKN6O 33
Losartan 114798-26-4 C22H23ClN6O 18
Candesartan (Cilexetil) 145040-37-5 C33H34N6O6 28
Candesartan 139481-59-7 C24H20N6O3 24
Tranilast (Sodium) 104931-56-8 C18H16NNaO5 6
Tranilast 53902-12-8 C18H17NO5 12
AVE 0991 (sodium salt) 306288-04-0 C29H31N4NaO5S2 8
AVE 0991 304462-19-9 C29H32N4O5S2 9
Telmisartan 144701-48-4 C33H30N4O2 32
Azilsartan (medoxomil monopotassium) 863031-24-7 C30H24KN4O8+ 8
Angiotensin II human 4474-91-3 C50H71N13O12 18
PD 123319 (ditrifluoroacetate) 136676-91-0 C35H34F6N4O7 15
Valsartan 137862-53-4 C24H29N5O3 32
Azilsartan 147403-03-0 C25H20N4O5 29
Azilsartan (medoxomil) 863031-21-4 C30H24N4O8 23
PD 123319 130663-39-7 C31H32N4O3 14
Olmesartan (medoxomil) 144689-63-4 C29H30N6O6 26
Olmesartan 144689-24-7 C24H26N6O3 17
Angiotensin acetate 58-49-1 C51H73N13O14 12

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:180-181°C
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,4 mg/mLwarmed(9.33 mM);In vitro:Ethanol,3 mg/mL(7.0 mM);In vitro:Water,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):30% PEG400+0.5% Tween80+5% propylene glycolFor be
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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