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Desonide

(CAS: 638-94-8)

Suppliers of Desonide

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AA Blocks LLC [email protected] +1 858-523-8231

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AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Jiangxi Yuneng Pharmchem Co., Ltd. [email protected] +86 (796) 840-2708 / +86 13307063230 China

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD50/10mg () USD90/50mg ()
Quality Control & MSDS Files: LCMS HNMR

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Price and Availability: USD110/10mg (In stock) USD140/10mM/1mLIn DMSO (In stock) USD370/50mg (In stock) USD670/100mg (In stock) USD1070/200mg (In stock)
Quality Control & MSDS Files: HNMR HPLC HPLC HNMR HPLC

Shandong Taihua Bio. & Tech. Co., Ltd. [email protected] +86 (538) 893-5055 China

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Target Molecule Corp. [email protected] (857) 239-0968 USA

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Tianjin Tianmao Technology Development Co., Ltd. [email protected] +86 (22) 2370-9100 China

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Xianju Belter Co., Ltd [email protected] 0086-576-87785883 CHINA

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Background Information of Desonide

Desonide is a nonfluorinated corticosteroid anti-inflammatory agent used topically for dermatoses. Target: Glucocorticoid Receptor Desonide is a low-potency topical corticosteroid that has been used for decades in the treatment of steroid-responsive dermatoses [1].

Solubility of Desonide

Solubility Sources
DMSO 85 mg/mL; Ethanol 40 mg/mL; Water <1 mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 83 mg/mL (199.27 mM); Ethanol30 mg/mL warming (72.02 mM); Water<1 mg/mL (<1 mM); In vivo 2% DMSO+49% PEG 300+dd H2O10mg/mL Selleck Chemicals LLC

Storage Condition of Desonide

Storage Condition Sources

MSDS Information

MSDS Sources

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [HNMR] MedChemexpress Co., Ltd.
[HNMR] [HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways GPCR/G Protein
Target Glucocorticoid Receptor
Research Area Inflammation/Immunology
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Desonide - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
416.51 C24H32O6 638-94-8 (11b,16a)-11,21-Dihydroxy-16,17-((1-methylethylidene)bis(oxy))-pregna-1,4-diene-3,20-dione; (6aR,6bS,7S,8aS,8bS,11aR,12aS,12bS)-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a,10,10-tetramethyl-6a,6b,7,8,8a,8b,11a,12,12a,12b-decahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4(2H)-one

Structure Information of Desonide

Smiles C[[email protected]@]12[[email protected]@](OC(C)(C)O3)(C(CO)=O)[[email protected]@]3([H])C[[email protected]@]1([H])[[email protected]@](CCC4=CC5=O)([H])[[email protected]]([[email protected]@]4(C)C=C5)([H])[[email protected]@H](O)C2
InChI InChI=1S/C24H32O6/c1-21(2)29-19-10-16-15-6-5-13-9-14(26)7-8-22(13,3)20(15)17(27)11-23(16,4)24(19,30-21)18(28)12-25/h7-9,15-17,19-20,25,27H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,20+,22-,23-,24+/m0/s1

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Other Form Products of Desonide

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:272-274?C
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,83 mg/mL(199.27 mM);In vitro:Ethanol,30 mg/mLwarmed(72.02 mM);In vitro:Water,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):2% DMSO+49% PEG 300+dd H2OFor best results,
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:211-351-6
Optical Rotation: alpha:

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