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NMS-1286937

(CAS: 1034616-18-6)

Suppliers of NMS-1286937

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AOBIOUS INC [email protected] (508) 306-0937 USA

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Active Biochem [email protected]; [email protected] 1-800-857-0985 (USA Toll Free#) USA

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Quality Control & MSDS Files: HNMR LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Target Molecule Corp. [email protected] (857) 239-0968 USA

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Background Information of NMS-1286937

NMS-1286937(NMS-P937) is an orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor(IC50=2 nM) with potential antineoplastic activity; no inhibition on PLK2 and PLK3. IC50 value: 2 nM [1] Target: PLK1 in vitro: NMS-P937 potently causes a mitotic cell-cycle arrest followed by apoptosis in cancer cell lines and inhibits xenograft tumor growth with clear PLK1-related mechanism of action at well-tolerated doses in mice after oral administration.

Solubility of NMS-1286937

Solubility Sources
DMSO MedChemexpress Co., Ltd.

Storage Condition of NMS-1286937

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Cell Cycle/DNA Damage
Target Polo-like Kinase (PLK)
Research Area Cancer
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
NMS-1286937 - Phase 1 Clinical
NMS-1286937 - Phase 1

Chemical Information

M.Wt Formula CAS No. Synonyms
532.52 C24H27F3N8O3 1034616-18-6 NMS-P937;NMS1286937;NMS 1286937;NMS P937; 1-(2-hydroxyethyl)-8-((5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

Structure Information of NMS-1286937

Smiles O=C(C1=NN(CCO)C2=C1CCC3=CN=C(NC4=CC(N5CCN(C)CC5)=CC=C4OC(F)(F)F)N=C23)N
InChI InChI=1S/C24H27F3N8O3/c1-33-6-8-34(9-7-33)15-3-5-18(38-24(25,26)27)17(12-15)30-23-29-13-14-2-4-16-20(22(28)37)32-35(10-11-36)21(16)19(14)31-23/h3,5,12-13,36H,2,4,6-11H2,1H3,(H2,28,37)(H,29,30,31)

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Chemical and Physical Properties

Appearance:Light yellow to yellow Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,42 mg/mLwarmed(78.87 mM);In vitro:Ethanol,10 mg/mLwarmed(18.77 mM);In vitro:Water,Insoluble;
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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