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Estriol

(CAS: 50-27-1)

Suppliers of Estriol

Company Name Email Tel Country
AbMole BioScience [email protected] 1-800-660-8580 USA

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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BOC Sciences [email protected] +1 (631) 398-3562 USA

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BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: 0.98 Brand: BOC Sciences

Price and Availability: USD199/20g (In stock)

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 0.98 Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD60/100mg () USD84/500mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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Discovery Fine Chemicals Ltd. [email protected] +44 (1202) 874-517

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Ivy Fine Chemicals [email protected] +1 (856) 465-8550 USA

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Jiangxi Hongyuan Pharmaceutical Raw Material Co., Ltd. [email protected] +86 (571) 8715-7521 China

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Jiangxi Yuneng Pharmchem Co., Ltd. [email protected] +86 (796) 840-2708 / +86 13307063230 China

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD60/100mg () USD84/500mg ()
Quality Control & MSDS Files: HNMR MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: Brand:

Melone Pharmaceutical Co., Ltd. [email protected],[email protected] +86 (411) 8259-3920 China

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Price and Availability: USD97/50mg (In stock) USD130/10mM/1mLIn DMSO (In stock)
Quality Control & MSDS Files: HNMR HPLC HNMR HPLC

Sequoia Research Products Ltd. [email protected] +44 (7802) 291-086

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD60/100mg () USD84/500mg ()

Shanghai Hongsheng Fine Chemical Industry Co., Ltd. [email protected],[email protected] +86 (21) 5426-5267 / +86 13901708303 China

Fax: +86 (21) 5426-5268Purity: Brand:

Shanghai Syntehtic Chem. Co., Ltd. [email protected],[email protected] +86 (21) 5250-0111 China

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Shuyang Yongfeng Chemical Co., Ltd. [email protected] +86 (576) 8850-5581 China

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Suzhou Sunray Pharmaceutical Co., Ltd. [email protected] +86 (512) 6841-8607 / 6808-6196 China

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Taizhou Yojoy Chemical Co., Ltd. [email protected] +86 (576) 8783-1166 / +86 18605861109 China

Fax: +86 (576) 8783-1189Purity: Brand:

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD20/2mg () USD41/10mg () USD85/50mg () USD122/200mg ()

Xiangyang Jinsheng Pharmaceutical Co., Ltd. [email protected] +86 (710) 357-7774 China

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Zhejiang Horde Pharma Co., Ltd [email protected] +86 571 85215531 85215532 CHINA

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Zhejiang Xianju Xianle Pharmaceutical Co., Ltd. [email protected] +86 (576) 8778-9188 China

Fax: +86 (576) 8779-3388Purity: Brand:

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Background Information of Estriol

Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells. Target: Estrogen Receptor/ERR A recent study shows that estrogen (estrone, estradiol, and estriol) inhibits Alzheimer's disease-associated low-order Aβ oligomer formation, and among them, estriol shows the strongest in vitro activity [1].

Solubility of Estriol

Solubility Sources
DMSO 57 mg/mL; Water <1 mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 57 mg/mL (197.64 mM); Ethanol10 mg/mL (34.67 mM); Water<1 mg/mL (<1 mM); In vivo 5% DMSO+95% Corn oil10 mg/mL Selleck Chemicals LLC

Storage Condition of Estriol

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] MedChemexpress Co., Ltd.
[HNMR] [HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Others
Target Estrogen Receptor/ERR
Research Area Cancer
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Estriol - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
288.38 C18H24O3 50-27-1 1,3,5(10)-Estratriene-3,16a,17b-triol; Estra-1,3,5(10)-triene-3,16alpha,17beta-triol; (8R,9S,13S,14S,16R,17R)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,16,17-triol

Structure Information of Estriol

Smiles C[[email protected]]1(CC2)[[email protected]](C[[email protected]@H](O)[[email protected]@H]1O)([H])[[email protected]@]3([H])[[email protected]@]2([H])C(C=CC(O)=C4)=C4CC3
InChI InChI=1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1

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Safety Data of Estriol

Hazard Symbols:T Risk Statements:R40;R60;R61 Safety Statements:S36/37;S45
Transport Information: HS Code: RTECS:KG8225000
WGK Germany:3

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:280-282 °C(lit.)
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,57 mg/mL(197.64 mM);In vitro:Ethanol,10 mg/mL(34.67 mM);In vitro:Water,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):5% DMSO+95% Corn oilFor best results, use promptl
Density: Merck:3707
BRN: Refractive Index: 58 ° (C=0.4, Dioxane)
Vapour: EINECS:200-022-2
Optical Rotation: alpha: yms1,3,5(10)-Estratriene-3,16a,17b-triol; Estra-1,3,5(10)-triene-3,16alpha,17beta-triol

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