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Olopatadine (hydrochloride)

(CAS: 140462-76-6)

Suppliers of Olopatadine (hydrochloride)

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AA Blocks LLC [email protected] +1 858-523-8231

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AbMole BioScience [email protected] 1-800-660-8580 USA

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AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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BOC Sciences [email protected] 1-631-504-6093

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Beijing Lang Rebone Technology Co., Ltd. [email protected] +86 (10) 5979-9429 / +86 18612220856 China

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Beijing Team Academy of Pharmaceutical Sciences Co., Ltd. [email protected],[email protected] +86 (10) 6818-0921 China

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD60/10mg () USD120/50mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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Dalian Wista Pharmaceutical Co., Ltd. [email protected],[email protected] +86 (10) 8492-5499 / 5257-7164 China

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD60/10mg () USD120/50mg ()
Quality Control & MSDS Files: HNMR LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Price and Availability: USD97/10mg (In stock) USD130/10mM/1mLIn DMSO (In stock) USD170/50mg (In stock)

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Suzhou Howsine Biological Technology Co., Ltd. [email protected],[email protected] +86 (512) 6812-8052 China

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Target Molecule Corp. [email protected] (857) 239-0968 USA

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Price and Availability: USD63/10mg () USD103/50mg () USD192/100mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

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Zhejiang Esun Chemical Co., Ltd. [email protected] +86 (571) 5628-6531 China

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Background Information of Olopatadine (hydrochloride)

Olopatadine HCl is a histamine blocker used to treat allergic conjunctivitis. Target: Histamine Receptor Olopatadine is one of the second-generation histamine H1 receptor antagonists that are treated for allergic disorders.

Solubility of Olopatadine (hydrochloride)

Solubility Sources
DMSO 75 mg/mL; Water 15 mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 75 mg/mL (200.6 mM); Water13 mg/mL (34.77 mM); Ethanol8 mg/mL (21.39 mM) Selleck Chemicals LLC
Soluble to 75 mM in water and to 100 mM in DMSO Tocris Bioscience Inc.

Storage Condition of Olopatadine (hydrochloride)

Storage Condition Sources
Desiccate at RT Tocris Bioscience Inc.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Immunology/Inflammation GPCR/G Protein
Target Histamine Receptor
Research Area Inflammation/Immunology
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Olopatadine (hydrochloride) - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
373.87 C21H24ClNO3 140462-76-6 (Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride; (Z)-2-(11-(3-(dimethylamino)propylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic acid hydrochloride

Structure Information of Olopatadine (hydrochloride)

Smiles O=C(O)CC1=CC=C(C/2=C1)OCC3=CC=CC=C3C2=CCCN(C)C.[H]Cl
InChI InChI=1S/C21H23NO3.ClH/c1-22(2)11-5-8-18-17-7-4-3-6-16(17)14-25-20-10-9-15(12-19(18)20)13-21(23)24;/h3-4,6-10,12H,5,11,13-14H2,1-2H3,(H,23,24);1H/b18-8-;

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Safety Data of Olopatadine (hydrochloride)

Hazard Symbols:T,N Risk Statements:25-50 Safety Statements:45-61
Transport Information: HS Code: RTECS:
WGK Germany:

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:242-245?C
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,75 mg/mL(200.6 mM);In vitro:Water,13 mg/mL(34.77 mM);In vitro:Ethanol,8 mg/mL(21.39 mM);
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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