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Desloratadine

(CAS: 100643-71-8)

Suppliers of Desloratadine

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AA Blocks LLC [email protected] +1 858-523-8231

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AbMole BioScience [email protected] 1-800-660-8580 USA

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

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Brook Chemical Limited [email protected],[email protected] +86 (21) 5276-2796 China

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD60/50mg () USD84/100mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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Hainan Poly Pharm Co., Ltd. [email protected] +86 (571) 2889-6329 China

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JACX Chemical Co., Ltd. [email protected] +86 (795) 450-8261 / +86 18970587571 China

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Jushin Chem (Ningbo) Co., Ltd. [email protected] +86 (574) 8770-6005 China

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD60/50mg () USD84/100mg ()
Quality Control & MSDS Files: LCMS HNMR MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Price and Availability: USD110/10mg (In stock) USD140/10mM/1mLIn DMSO (In stock) USD370/50mg (In stock)
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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Shenzhen Salubris Pharmaceuticals Co., Ltd. [email protected] +86 (755) 8386-7888 China

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Target Molecule Corp. [email protected] (857) 239-0968 USA

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Price and Availability: USD95/10mg () USD246/50mg () USD369/100mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

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Wenling Tongda Fine Chemical Co., Ltd [email protected] 86-0576-86183883 CHINA

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Background Information of Desloratadine

Desloratadine(Sch34117) is a potent antagonist for human histamine H1 receptor used to treat allergies. Target: Histamine H1 Receptor Desloratadine binds to the human H1 receptor with Ki value of 0.87 nM in displacing tritiated mepyramine.

Solubility of Desloratadine

Solubility Sources
DMSO 26 mg/mL; Water <1 mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 26 mg/mL (83.64 mM); Ethanol62 mg/mL (199.47 mM); Water<1 mg/mL (<1 mM); In vivo 30% Propylene glycol, 5% Tween 80, 65% D5W30 mg/mL Selleck Chemicals LLC

Storage Condition of Desloratadine

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [HNMR] MedChemexpress Co., Ltd.
[HNMR] [HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Immunology/Inflammation GPCR/G Protein
Target Histamine Receptor
Research Area Inflammation/Immunology
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Desloratadine - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
310.82 C19H19ClN2 100643-71-8 Clarinex;Neoclarityn;Sch34117; 8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine

Structure Information of Desloratadine

Smiles ClC1=CC=C2C(CCC3=CC=CN=C3/C2=C4CCNCC/4)=C1
InChI InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:150-151°C
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:Ethanol,62 mg/mL(199.47 mM);In vitro:DMSO,26 mg/mL(83.64 mM);In vitro:Water,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):4% DMSO+40% PEG 300+4% Tween 80+ddH2OFor best res
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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