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Methazolamide

(CAS: 554-57-4)

Suppliers of Methazolamide

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AA Blocks LLC [email protected] +1 858-523-8231

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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BOC Sciences [email protected] 1-631-504-6093

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD60/100mg () USD84/500mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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Changzhou Xiangren Chemical Technology Co., Ltd. [email protected] +86 (519) 8285-0370 China

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Hangzhou Fst Pharmaceutical Co., Ltd. [email protected],[email protected] +86 (571) 8893-8516 China

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Hangzhou Fushitang Biology Technology Co., Ltd. [email protected] +86 (571) 8893-8530 China

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD60/100mg () USD84/500mg ()
Quality Control & MSDS Files: LCMS HNMR MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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Porton Corporation [email protected] +86 (23) 6763-5888 China

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Price and Availability: USD97/50mg (In stock) USD130/10mM/1mLIn DMSO (In stock)
Quality Control & MSDS Files: HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD20/2mg () USD65/10mg () USD154/50mg ()

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Background Information of Methazolamide

Methazolamide is a carbonic anhydrase inhibitor used to treat glaucoma. Target: Carbonic Anhydrase Methazolamide is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively [1].

Solubility of Methazolamide

Solubility Sources
DMSO 48 mg/mL; Water <1 mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 47 mg/mL (198.92 mM); Ethanol3 mg/mL (12.69 mM); Water<1 mg/mL (<1 mM) Selleck Chemicals LLC

Storage Condition of Methazolamide

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [HNMR] MedChemexpress Co., Ltd.
[HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Metabolic Enzyme/Protease
Target Carbonic Anhydrase
Research Area Others
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Methazolamide - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
236.27 C5H8N4O3S2 554-57-4 N-[(2E)-5-(Aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide; (E)-N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene)acetamide

Structure Information of Methazolamide

Smiles CN1/C(SC(S(N)(=O)=O)=N1)=NC(C)=O
InChI InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)/b7-4+

Related Products

Other Form Products of Methazolamide

Name CAS Formula Suppliers

Recommended Products in Same Target

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Dichlorphenamide 120-97-8 C6H6Cl2N2O4S2 13
Dorzolamide (hydrochloride) 130693-82-2 C10H17ClN2O4S3 13
Dimethylfraxetin 6035-49-0 C12H12O5 6
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U-104 178606-66-1 C13H12FN3O3S 18
Acetazolamide 59-66-5 C4H6N4O3S2 17
Acetazolamide D3 1189904-01-5 C4H3D3N4O3S2 4
Dorzolamide 120279-96-1 C10H16N2O4S3 5

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Safety Data of Methazolamide

Hazard Symbols:Xn Risk Statements:R20/21/22;R40 Safety Statements:S22;S36
Transport Information: HS Code: RTECS:AC6350000
WGK Germany:3

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:208 °C (dec.)(lit.)
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,47 mg/mL(198.92 mM);In vitro:Ethanol,3 mg/mL(12.69 mM);In vitro:Water,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):2% DMSO+30% PEG 300+2% Tween 80+ddH2OFor best resu
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:209-066-7
Optical Rotation: alpha:

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