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H-89 (dihydrochloride)

(CAS: 130964-39-5)

Suppliers of H-89 (dihydrochloride)

Company Name Email Tel Country
AbMole BioScience [email protected] 1-800-660-8580 USA

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Price and Availability: USD63/10mg (In stock)

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD67/10mg () USD259/50mg ()

LC Laboratoies [email protected] +1-781-937-0777 +1-800-937-3720 in US and Canada only USA

Fax: +1-781-938-5420Purity: > 99% Brand:

Price and Availability: USD57/10mg (In stock) USD119/25mg (In stock) USD399/100mg (In stock) USD975/300mg (In stock)

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD67/10mg () USD259/50mg ()
Quality Control & MSDS Files: LCMS NP-HPLC HNMR MSDS

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: >98% Brand:

Price and Availability: USD90/10mg (In stock) USD120/10mM/1mLIn DMSO (In stock) USD151/10mM(in 1mL DMSO) (in 1mL DMSO) USD310/50mg (In stock) USD880/200mg (In stock)
Quality Control & MSDS Files: HNMR HPLC HNMR HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD67/10mg () USD259/50mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD85/10mg () USD132/25mg () USD209/50mg () USD388/100mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

Fax: +1 (636) 207-7683Purity: Brand:

Price and Availability: USD85/1mg ()

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Background Information of H-89 (dihydrochloride)

H-89 (dihydrochloride) is a potent inhibitor of cyclic AMP-dependent protein kinase (protein kinase A) with IC50 of 48 nM and has weak inhibition on PKG, PKC, Casein Kinase, and others kinases.

Solubility of H-89 (dihydrochloride)

Solubility Sources
Soluble in DMSO at 100 mg/ml; soluble in ethanol at 2 mg/ml with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 50-100 pM; buffers, serum or other additives may increase or decrease the aqueous solubility. LC Laboratoies
DMSO 50 mg/ml MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 104 mg/mL (200.27 mM); Water6 mg/mL (11.55 mM); Ethanol<1 mg/mL (<1 mM); In vivo 1% DMSO+30% polyethylene glycol+1% Tween 8030 mg/mL Selleck Chemicals LLC

Storage Condition of H-89 (dihydrochloride)

Storage Condition Sources
Store desiccated at or below -20 oC. LC Laboratoies
4°C MedChemexpress Co., Ltd.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [NP-HPLC] [HNMR] MedChemexpress Co., Ltd.
[HNMR] [HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Protein Tyrosine Kinase/RTK Autophagy Stem Cell/Wnt
Target PKA Autophagy
Research Area Others

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
H-89 (dihydrochloride) - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
519.2826 C20H22BrCl2N3O2S 130964-39-5 Protein kinase inhibitor H-89 dihydrochloride

Structure Information of H-89 (dihydrochloride)

Smiles O=S(C1=CC=CC2=C1C=CN=C2)(NCCNC/C=C/C3=CC=C(Br)C=C3)=O.Cl.Cl
InChI InChI=1S/C20H20BrN3O2S.2ClH/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20;;/h1-10,12,15,22,24H,11,13-14H2;2*1H/b3-2+;;

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:DMSO 50 mg/mL
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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