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LY-411575 (isomer 1)

(CAS: 209984-58-7)

Suppliers of LY-411575 (isomer 1)

Company Name Email Tel Country
Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: Brand:

Price and Availability: USD104/5mg () USD188/10mg () USD560/50mg () USD912/100mg ()

Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

Fax: +1 (847) 367-3681Purity: Brand:

BOC Sciences [email protected] 1-631-504-6093

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD1800/1mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD1800/1mg ()
Quality Control & MSDS Files: LCMS HNMR

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD1800/1mg ()

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Background Information of LY-411575 (isomer 1)

LY-411575 isomer 1 is a isomer of LY411575, which is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch clevage with withIC50 of 0.39 nM. IC50 value: 0.078 nM/0.082 nM (membrane/cell-based) [1] Target: γ-secretase in vitro: LY-411575 inhibits γ-secretase which can be assessed by the substrates like amyloid precursor protein (APP) and Notch S3 cleavage [1].

Solubility of LY-411575 (isomer 1)

Solubility Sources
DMSO MedChemexpress Co., Ltd.

Storage Condition of LY-411575 (isomer 1)

Storage Condition Sources

MSDS Information

MSDS Sources

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [HNMR] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Neuronal Signaling Stem Cell/Wnt
Target γ-secretase
Research Area Neurological Disease
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
LY-411575 (isomer 1) - Not Found
LY-411575 (isomer 1) - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
479.48 C26H23F2N3O4 209984-58-7 LY411575 isomer 1; LY 411575 isomer 1; (S)-2-((R)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propanamide

Structure Information of LY-411575 (isomer 1)

Smiles C[[email protected]](NC([[email protected]](O)C1=CC(F)=CC(F)=C1)=O)C(N[[email protected]](C(N2C)=O)C3=CC=CC=C3C4=C2C=CC=C4)=O
InChI InChI=1S/C26H23F2N3O4/c1-14(29-25(34)23(32)15-11-16(27)13-17(28)12-15)24(33)30-22-20-9-4-3-7-18(20)19-8-5-6-10-21(19)31(2)26(22)35/h3-14,22-23,32H,1-2H3,(H,29,34)(H,30,33)/t14-,22-,23+/m0/s1

Related Products

Other Form Products of LY-411575 (isomer 1)

Name CAS Formula Suppliers
LY-411575 209984-57-6 C26H23F2N3O4 17

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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