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Sivelestat (sodium)

(CAS: 150374-95-1)

Suppliers of Sivelestat (sodium)

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AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Shanghai Julong Pharmaceutical R & D Co., Ltd [email protected] 0519-85252351 CHINA

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Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

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Background Information of Sivelestat (sodium)

Sivelestat sodium(ONO5046; LY544349; EI546) is a competitive inhibitor of human neutrophil elastase(IC50 = 44 nM; Ki=200 nM); also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse. IC50 value: 44 nM [1] Target: neutrophil elastase ONO-5046 did not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 microM.

Solubility of Sivelestat (sodium)

Solubility Sources
DMSO MedChemexpress Co., Ltd.

Storage Condition of Sivelestat (sodium)

Storage Condition Sources

MSDS Information

MSDS Sources

Quality Control and Spectral Data

QC Reports Sources

Mechanism and Indications

Signaling Pathways Metabolic Enzyme/Protease
Target Elastase
Research Area Others

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Sivelestat (sodium) - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
456.44 C20H21N2NaO7S 150374-95-1 N-[2-[[[4-(2,2-Dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-(S)-glycine monosodium salt; sodium 2-(2-(4-(pivaloyloxy)phenylsulfonamido)benzamido)acetate

Structure Information of Sivelestat (sodium)

Smiles O=C([O-])CNC(C1=CC=CC=C1NS(=O)(C2=CC=C(OC(C(C)(C)C)=O)C=C2)=O)=O.[Na+]
InChI InChI=1S/C20H22N2O7S.Na/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24;/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24);/q;+1/p-1

Related Products

Other Form Products of Sivelestat (sodium)

Name CAS Formula Suppliers
Sivelestat 127373-66-4 C20H22N2O7S 15
Sivelestat (sodium tetrahydrate) 201677-61-4 C20H29N2NaO11S 15

Recommended Products in Same Target

Name CAS Formula Suppliers
GW311616 (hydrochloride) 197890-44-1 C19H32ClN3O4S 8
GW311616 198062-54-3 C19H31N3O4S 9
Sivelestat 127373-66-4 C20H22N2O7S 15
Alvelestat 848141-11-7 C25H22F3N5O4S 12
DMP 777 157341-41-8 C31H40N4O6 8
Sivelestat (sodium tetrahydrate) 201677-61-4 C20H29N2NaO11S 15
ZD8321 182073-77-4 C18H28F3N3O5 4

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Chemical and Physical Properties

Appearance: Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:DMSO:22.82mg/mL;50mM;
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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