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Tiagabine (hydrochloride)

(CAS: 145821-59-6)

Suppliers of Tiagabine (hydrochloride)

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AbMole BioScience [email protected] 1-800-660-8580 USA

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AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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Alfa Chemistry [email protected] 1-201-478-8534 USA

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Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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BOC Sciences [email protected] 1-631-504-6093

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD60/10mg () USD144/50mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD60/10mg () USD144/50mg ()
Quality Control & MSDS Files: HNMR LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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Nectar Industrial Co., Ltd. [email protected] +86 (755) 8100-9345 China

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Shandong Boyuan Pharmaceutical Co., Ltd. [email protected],[email protected] +86 (531) 6995-4981 / 8896-3280 China

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Price and Availability: USD60/10mg () USD144/50mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

Fax: +1 (636) 207-7683Purity: #99 % Brand: Tocris

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Background Information of Tiagabine (hydrochloride)

Tiagabine hydrochloride(NO328 hydrochloride) is a selective gamma-aminobutyric acid (GABA) reuptake inhibitor. Target: GABA reuptake inhibitor Tiagabine had an early onset of effect, as shown by significant reduction from baseline in mean HAM-A total score compared with placebo at week 1 (observed cases, p < .05).

Solubility of Tiagabine (hydrochloride)

Solubility Sources
DMSO MedChemexpress Co., Ltd.
Soluble to 50 mM in water and to 100 mM in DMSO Tocris Bioscience Inc.

Storage Condition of Tiagabine (hydrochloride)

Storage Condition Sources
Desiccate at RT Tocris Bioscience Inc.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Membrane Transporter/Ion Channel Neuronal Signaling
Target GABA Receptor
Research Area Neurological Disease
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Tiagabine (hydrochloride) - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
412.01 C20H26ClNO2S2 145821-59-6 (3R)-1-[4,4-Bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic acid hydrochloride; (R)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-en-1-yl)piperidine-3-carboxylic acid hydrochloride

Structure Information of Tiagabine (hydrochloride)

Smiles CC1=C(SC=C1)/C(C2=C(C)C=CS2)=CCCN3C[[email protected]](C(O)=O)CCC3.Cl
InChI InChI=1S/C20H25NO2S2.ClH/c1-14-7-11-24-18(14)17(19-15(2)8-12-25-19)6-4-10-21-9-3-5-16(13-21)20(22)23;/h6-8,11-12,16H,3-5,9-10,13H2,1-2H3,(H,22,23);1H/t16-;/m1./s1

Related Products

Other Form Products of Tiagabine (hydrochloride)

Name CAS Formula Suppliers
Tiagabine (hydrochloride) 145821-59-6 C20H26ClNO2S2 8

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Safety Data of Tiagabine (hydrochloride)

Hazard Symbols:Xn,T,F Risk Statements:20/21/22-39/23/24/25-23/24/25-11 Safety Statements:36/37-45-16-7
Transport Information: HS Code: RTECS:
WGK Germany:

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:>192oC dec.
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,82 mg/mL(199.02 mM);In vitro:Ethanol,82 mg/mL(199.02 mM);In vitro:Water,11 mg/mL(26.69 mM);
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:200-659-6
Optical Rotation: alpha:

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