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Exatecan (Mesylate)

(CAS: 169869-90-3)

Suppliers of Exatecan (Mesylate)

Company Name Email Tel Country
Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: Brand:

Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

Fax: +1 (847) 367-3681Purity: Brand:

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

Price and Availability: USD298/1mg (In stock) USD998/10mg (In stock)

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 0.98 Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD660/1mg () USD1176/5mg ()

Hangzhou Guangyuan Biotechnology Co., Ltd. [email protected]; [email protected] 0571-88690598 4001686671 CHINA

Fax: 0571-88690598Purity: > 98% Brand: RayStarBio

Price and Availability: USD800/5mg (In stock)

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD660/1mg () USD1176/5mg ()
Quality Control & MSDS Files: HNMR NP-HPLC LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: Brand:

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD660/1mg () USD1176/5mg ()

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Background Information of Exatecan (Mesylate)

Exatecan Mesylate (DX-8951) is a totally synthetic analogue of the topoisomerase I-inhibitor camptothecin, which was synthesised to impart increased aqueous solubility, greater tumour efficacy, and less toxicity than camptothecin itself. IC50 value: Target: topoisomerase I Exatecan was given as i.v.

Solubility of Exatecan (Mesylate)

Solubility Sources
DMSO MedChemexpress Co., Ltd.

Storage Condition of Exatecan (Mesylate)

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [NP-HPLC] [LCMS] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Cell Cycle/DNA Damage
Target Topoisomerase
Research Area Cancer
Indications Pancreatic Cancer

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Exatecan (Mesylate) Daiichi Sankyo Inc. Pancreatic Cancer 2001/7/01 2005/4/01 Phase 3 Clinical
Exatecan (Mesylate) - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
531.55 C25H26FN3O7S 169869-90-3 DX8951f;DX 8951f;DX-8951f; (1S,9S)-1-amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-2,3,12,15-tetrahydrobenzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13(1H,9H)-dione methanesulfonate

Structure Information of Exatecan (Mesylate)

Smiles O=S(C)(O)=O.O=C1[[email protected]](O)(CC)C2=C(CO1)C(N3CC4=C5C6=C(CC[[email protected]@H]5N)C(C)=C(F)C=C6N=C4C3=C2)=O
InChI InChI=1S/C24H22FN3O4.CH4O3S/c1-3-24(31)14-6-18-21-12(8-28(18)22(29)13(14)9-32-23(24)30)19-16(26)5-4-11-10(2)15(25)7-17(27-21)20(11)19;1-5(2,3)4/h6-7,16,31H,3-5,8-9,26H2,1-2H3;1H3,(H,2,3,4)/t16-,24-;/m0./s1

Related Products

Other Form Products of Exatecan (Mesylate)

Name CAS Formula Suppliers
Exatecan 171335-80-1 C24H22FN3O4 9

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:Soluble in DMSO
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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