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Jervine

(CAS: 469-59-0)

Suppliers of Jervine

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AbMole BioScience [email protected] 1-800-660-8580 USA

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AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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BOC Sciences [email protected] 1-631-504-6093

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BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD125/5mg () USD225/10mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD125/5mg () USD225/10mg ()
Quality Control & MSDS Files: LCMS HNMR MSDS

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Price and Availability: USD125/5mg () USD225/10mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

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Background Information of Jervine

Jervine(11-Ketocyclopamine) is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog(Shh) signaling; Jervine is an inhibitor of Smo. IC50 value: Target: sonic hedgehog is derived from the Veratrum plant species.

Solubility of Jervine

Solubility Sources
Soluble in ethanol (10 mg/ml warm), DMF (6 mg/ml), DMSO (5 mg/ml); insoluble in water MedChemexpress Co., Ltd.

Storage Condition of Jervine

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [HNMR] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Stem Cell/Wnt
Target Hedgehog Smo
Research Area Cancer
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Jervine - Not Found
Jervine - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
425.6 C27H39NO3 469-59-0 (2'R,3S,3'R,3a'S,6aS,6bS,6'S,7a'R,11aS,11bR)-3-hydroxy-3',6',10,11b-tetramethyl-1,3,3a',4,4',5',6,6a,6b,6',7,7',7a',8,11a,11b-hexadecahydro-3'H-spiro[benzo[a]fluorene-9,2'-furo[3,2-b]pyridin]-11(2H)-one

Structure Information of Jervine

Smiles CC1=C(C2=O)[[email protected]@]([[email protected]]3([H])CC=C4[[email protected]@](CC[[email protected]](O)C4)(C)[[email protected]@]23[H])([H])CC[[email protected]]1([[email protected]](C)[[email protected]]5([H])NC6)O[[email protected]]5([H])C[[email protected]@H]6C
InChI InChI=1S/C27H39NO3/c1-14-11-21-24(28-13-14)16(3)27(31-21)10-8-19-20-6-5-17-12-18(29)7-9-26(17,4)23(20)25(30)22(19)15(27)2/h5,14,16,18-21,23-24,28-29H,6-13H2,1-4H3/t14-,16+,18-,19-,20-,21+,23+,24-,26-,27-/m0/s1

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Chemical and Physical Properties

Appearance:White to off-white solid Melting point:242- 244°C
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,5 mg/mL(11.74 mM);In vitro:Ethanol,2 mg/mL(4.69 mM);In vitro:Water,Insoluble;
Density:1.18±0.1 g/cm3 (20 ºC 760 Torr), Calc.* Merck:
BRN: Refractive Index:
Vapour: EINECS:207-417-9
Optical Rotation: alpha:

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