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Posizolid

(CAS: 252260-02-9)

Suppliers of Posizolid

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ABI Chem [email protected] Germany

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Alfa Chemistry [email protected] 1-201-478-8534 USA

Fax: 1-516-927-0118Purity: 0.96 Brand: Alfa Chemistry

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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Qingdao Yimingxiang Fine Chemical Technology Co., Ltd. [email protected] +86 (532) 8068-2118 China

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Background Information of Posizolid

Posizolid, also known as AZD-5847 and AZD-2563, is an oxazolidinone antibiotic under investigation by AstraZeneca for the treatment of bacterial infections. At a concentration of 2 mg/L it inhibited 98% of all Gram-positive bacteria tested in vitro. The overall MIC90 was 1.0 mg/liter (range, 0.125 to 4 mg/liter). The MICs of AZD5847 for isolates of Mycobacterium tuberculosis were similar among drug-sensitive strains, multidrug-resistant (MDR) strains, and extensively drug resistant (XDR) strains. The good in vitro activity of AZD5847 against M. tuberculosis and the lack of cross-resistance make this agent a promising anti-TB drug candidate.

Solubility of Posizolid

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Storage Condition of Posizolid

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MSDS Information

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Quality Control and Spectral Data

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Mechanism and Indications

Signaling Pathways
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Posizolid - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
465.4 C21H21F2N3O7 252260-02-9 AZD 2563; AZD 5847; (R)-3-(4-(1-((S)-2,3-dihydroxypropanoyl)-1,2,3,6-tetrahydropyridin-4-yl)-3,5-difluorophenyl)-5-((isoxazol-3-yloxy)methyl)oxazolidin-2-one

Structure Information of Posizolid

Smiles O=C1O[[email protected]@H](COC2=NOC=C2)CN1C3=CC(F)=C(C4=CCN(C([[email protected]@H](O)CO)=O)CC4)C(F)=C3
InChI InChI=1S/C21H21F2N3O7/c22-15-7-13(26-9-14(33-21(26)30)11-31-18-3-6-32-24-18)8-16(23)19(15)12-1-4-25(5-2-12)20(29)17(28)10-27/h1,3,6-8,14,17,27-28H,2,4-5,9-11H2/t14-,17+/m1/s1

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Chemical and Physical Properties

Appearance: Melting point:
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Water Solubility: Solubility:Soluble in DMSO, not in water
Density:1.491 Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

Reference

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