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Tubulysin A

(CAS: 205304-86-5)

Suppliers of Tubulysin A

Company Name Email Tel Country
Alfa Chemistry [email protected] 1-201-478-8534 USA

Fax: 1-516-927-0118Purity: 0.96 Brand: Alfa Chemistry

Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

Fax: +1 (847) 367-3681Purity: Brand:

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 0.98 Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD2064/1mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD2064/1mg ()

Santa Cruz Biotechnology, Inc. [email protected] Toll Free: 800-457-3801 Phone: 214-902-3900 USA

Fax: 214-358-6070Purity: Brand:

Price and Availability: USD460/200ug ()

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD2064/1mg ()

Sigma-Aldrich, Inc. [email protected] +86 (21) 6141-5566 / 800-819-3336 USA

Fax: Purity: Brand:

Price and Availability: USD476/200ug ()

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Background Information of Tubulysin A

Tubulysin A(TubA) is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays; anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. IC50 value: Target: microtubule Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative.

Solubility of Tubulysin A

Solubility Sources
DMSO MedChemexpress Co., Ltd.

Storage Condition of Tubulysin A

Storage Condition Sources

MSDS Information

MSDS Sources

Quality Control and Spectral Data

QC Reports Sources

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Tubulysin A Endocyte Solid Tumors; Triple-Negative Breast Cancer (TNBC); Advanced Non-Small Cell Lung Cancer (NSCLC); Ovarian Cancer; Hepatocellular Carcinoma (HCC) 2013/10/01 Phase 1 Clinical
Tubulysin A - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
844.07 C43H65N5O10S 205304-86-5 TubA; (2S,4R)-4-(2-((1R,3R)-1-acetoxy-4-methyl-3-((2S,3S)-3-methyl-N-(((3-methylbutanoyl)oxy)methyl)-2-((R)-1-methylpiperidine-2-carboxamido)pentanamido)pentyl)thiazole-4-carboxamido)-5-(4-hydroxyphenyl)-2-methylpentanoic acid

Structure Information of Tubulysin A

Smiles O=C([[email protected]@]([[email protected]@H](C)CC)([H])NC([[email protected]@H](CCCC1)N1C)=O)N(COC(CC(C)C)=O)[[email protected]@H](C(C)C)C[[email protected]](C2=NC(C(N[[email protected]](C[[email protected]](C)C(O)=O)CC3=CC=C(O)C=C3)=O)=CS2)OC(C)=O
InChI InChI=1S/C43H65N5O10S/c1-10-27(6)38(46-40(53)34-13-11-12-18-47(34)9)42(54)48(24-57-37(51)19-25(2)3)35(26(4)5)22-36(58-29(8)49)41-45-33(23-59-41)39(52)44-31(20-28(7)43(55)56)21-30-14-16-32(50)17-15-30/h14-17,23,25-28,31,34-36,38,50H,10-13,18-22,24H2,1-9H3,(H,44,52)(H,46,53)(H,55,56)/t27-,28-,31+,34+,35+,36+,38-/m0/s1

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Chemical and Physical Properties

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Optical Rotation: alpha:

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