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VT-464

(CAS: 1610537-15-9)

Suppliers of VT-464

Company Name Email Tel Country
Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: Brand:

Price and Availability: USD332/5mg () USD475/10mg () USD1425/50mg () USD1995/100mg ()

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: >98% Brand:

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: >98% Brand:

Price and Availability: USD350/5mg (In stock) USD500/10mg (In stock) USD1500/50mg (In stock) USD2100/100mg (In stock)
Quality Control & MSDS Files: HNMR LCMS NP-HPLC MSDS

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: >98% Brand:

Price and Availability: USD350/5mg (Get quote) USD500/10mg (Get quote) USD1500/50mg (Get quote) USD2100/100mg (Get quote)

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Background Information of VT-464

VT-464 is a potent CYP17 lyase inhibitor(h-Lyase IC50=69 nM) that demonstrated both exceptional in vitro lyase/hydroxylase selectivity (~10-fold) and oral activity in a hamster model of androgen biosynthesis inhibition. IC50 value: 69 nM(h-CYP17 Lyase) [1] Target: CYP17 Lyase inhibitor in vitro: VT-464, a non-steroidal small molecule inhibits androgen production without mineralocorticoid excess or cortisol depletion by selective inhibition of CYP17 17,20-lyase.

Solubility of VT-464

Solubility Sources
DMSO MedChemexpress Co., Ltd.

Storage Condition of VT-464

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] [NP-HPLC] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Metabolic Enzyme/Protease
Target Cytochrome P450
Research Area Cancer
Indications Prostate Cancer Castration-resistant Prostate Cancer

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
VT-464 Viamet Pharmaceuticals, Inc. Prostate Cancer 2014/4/22 Phase 2 Clinical
VT-464 Viamet Pharmaceuticals, Inc. Castration-resistant Prostate Cancer 2013/12/06 Phase 2 Clinical
VT-464 - Phase 2

Chemical Information

M.Wt Formula CAS No. Synonyms
399.34 C18H17F4N3O3 1610537-15-9 VT464;VT 464; (S)-1-(6,7-bis(difluoromethoxy)naphthalen-2-yl)-2-methyl-1-(1H-1,2,3-triazol-4-yl)propan-1-ol

Structure Information of VT-464

Smiles FC(F)OC1=C(OC(F)F)C=C(C=CC([[email protected]](C2=CNN=N2)(C(C)C)O)=C3)C3=C1
InChI InChI=1S/C18H17F4N3O3/c1-9(2)18(26,15-8-23-25-24-15)12-4-3-10-6-13(27-16(19)20)14(28-17(21)22)7-11(10)5-12/h3-9,16-17,26H,1-2H3,(H,23,24,25)/t18-/m0/s1

Related Products

Other Form Products of VT-464

Name CAS Formula Suppliers
VT-464 (racemate) 1375603-36-3 C18H17F4N3O3 4
VT-464 (R enantiomer) 1375603-38-5 C18H17F4N3O3 3

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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