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PFK-158

(CAS: 1462249-75-7)

Suppliers of PFK-158

Company Name Email Tel Country
AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

Fax: 866-333-9607 (US & Canada Toll Free) +1-323-606-8156 (Outside of US & Canada)Purity: Brand:

Price and Availability: USD350/5mg () USD600/10mg () USD1200/25mg ()

Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

Fax: +1 (847) 367-3681Purity: Brand:

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD108/5mg () USD144/10mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

Fax: (734) 971-3640Purity: Brand:

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD108/5mg () USD144/10mg ()
Quality Control & MSDS Files: LCMS HNMR MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: Brand:

ProbeChem [email protected] 86-21-80183644

Fax: 86-21-68860190Purity: Brand:

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD108/5mg () USD144/10mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD107/1mg () USD291/5mg () USD485/10mg () USD926/25mg () USD1320/50mg ()

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Background Information of PFK-158

PFK-158 is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFK-2/FBPase) isoform 3 (PFKFB3) and derivative of 3-(3-pyridinyl)-1-[4-pyridinyl]-2-propen-1-one (3PO), with potential antineoplastic activity.

Solubility of PFK-158

Solubility Sources
DMSO: ≥ 30 mg/mL CHEMSCENE, LLC
DMSO: ≥ 30 mg/mL MedChemexpress Co., Ltd.

Storage Condition of PFK-158

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [HNMR] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Others
Target Others
Research Area Cancer
Indications Cancer

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
PFK-158 Advanced Cancer Therapeutics Cancer 2014/1/22 2015/6/01 Phase 1 Clinical
PFK-158 - Phase 1

Chemical Information

M.Wt Formula CAS No. Synonyms
328.29 C18H11F3N2O 1462249-75-7 PFK 158;PFK158; (E)-1-(pyridin-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)prop-2-en-1-one

Structure Information of PFK-158

Smiles O=C(C1=CC=NC=C1)/C=C/C2=NC3=CC(C(F)(F)F)=CC=C3C=C2
InChI InChI=1S/C18H11F3N2O/c19-18(20,21)14-3-1-12-2-4-15(23-16(12)11-14)5-6-17(24)13-7-9-22-10-8-13/h1-11H/b6-5+

Related Products

Other Form Products of PFK-158

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CID-797718 370586-05-3 C12H11NO3 12

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Tariquidar (methanesulfonate, hydrate) 625375-83-9 C40H52N4O15S2 10
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Romidepsin 128517-07-7 C24H36N4O6S2 21
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Erlotinib 183321-74-6 C22H16D8ClN3O4 17
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LY-2584702 (free base) 1082949-67-4 C21H19F4N7 12
LY-2584702 (tosylate salt) 1082949-68-5 C28H27F4N7O3S 14
GSK2110183 1047634-63-8 C18H16Cl2F2N4OS 6
Afuresertib 1047644-62-1 C18H17Cl2FN4OS 16

Chemical and Physical Properties

Appearance:Light yellow to yellow Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:DMSO
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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